Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

Journal Article · · Nat. Commun.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
DOE Contract Number:
NONE;
OSTI ID:
1861850
Journal Information:
Nat. Commun., Journal Name: Nat. Commun. Vol. 13
Country of Publication:
United States
Language:
ENGLISH

References (92)

An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in 1 H-Detected Solid-State NMR Spectroscopy journal November 2015
1 H-Detected Solid-State NMR Studies of Water-Inaccessible Proteins In Vitro and In Situ journal September 2016
Supramolecular Organization and Functional Implications of K +  Channel Clusters in Membranes journal August 2017
Scalable molecular dynamics with NAMD journal January 2005
CHARMM-GUI: A web-based graphical user interface for CHARMM journal March 2008
THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method journal October 1992
VMD: Visual molecular dynamics journal February 1996
Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region journal October 1991
Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels journal August 1993
Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms journal October 1995
Mutations in the K+ channel signature sequence journal April 1994
An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding journal April 1994
A Permeant Ion Binding Site Located between Two Gates of the Shaker K+ Channel journal April 1998
Replica-exchange multicanonical algorithm and multicanonical replica-exchange method for simulating systems with rough energy landscape journal October 2000
Extension to the weighted histogram analysis method: combining umbrella sampling with free energy calculations journal March 2001
Pore accessibility during C-type inactivation in Shaker K + channels journal June 1998
Potassium Channelopathies journal June 1997
A Conserved Glutamate Is Important for Slow Inactivation in K+ Channels journal September 2000
A Multipoint Hydrogen-Bond Network Underlying KcsA C-Type Inactivation journal May 2011
Cryo-EM Structure of the Open Human Ether-à-go-go -Related K + Channel hERG journal April 2017
Generalized scalable multiple copy algorithms for molecular dynamics simulations in NAMD journal March 2014
Efficient heteronuclear decoupling by quenching rotary resonance in solid-state NMR journal December 2008
Broadband magnetization transfer using moderate radio-frequency fields for NMR with very high static fields and spinning speeds journal March 2010
Open and Closed Structures of a Barium-Blocked Potassium Channel journal August 2020
Sodium Ions Do Not Stabilize the Selectivity Filter of a Potassium Channel journal July 2021
Low-power decoupling at high spinning frequencies in high static fields journal August 2009
A structural interpretation of voltage-gated potassium channel inactivation journal October 2006
Hydrogen bond strength in membrane proteins probed by time-resolved 1 H-detected solid-state NMR and MD simulations journal October 2017
A Gate in the Selectivity Filter of Potassium Channels journal April 2005
Voltage gating of ion channels journal February 1994
Advances in Solid-State Relaxation Methodology for Probing Site-Specific Protein Dynamics journal April 2013
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles journal August 2012
Improved Treatment of the Protein Backbone in Empirical Force Fields journal January 2004
Quantitative Analysis of the Water Occupancy around the Selectivity Filter of a K + Channel in Different Gating Modes journal January 2014
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types journal June 2010
All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins † journal April 1998
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution journal November 2001
Energetics of ion conduction through the K+ channel journal November 2001
The voltage-gated potassium channels and their relatives journal September 2002
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR journal April 2006
Structural basis for the coupling between activation and inactivation gates in K+ channels journal July 2010
Structural mechanism of C-type inactivation in K+ channels journal July 2010
Recovery from slow inactivation in K+ channels is controlled by water molecules journal July 2013
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel journal September 2015
CHARMM36m: an improved force field for folded and intrinsically disordered proteins journal November 2016
Voltage-gated potassium channels as therapeutic targets journal December 2009
A structural link between inactivation and block of a K+ channel journal May 2008
On the structural basis of modal gating behavior in K+ channels journal December 2010
Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel journal August 2017
Molecular determinants of gating at the potassium-channel selectivity filter journal March 2006
A single NaK channel conformation is not enough for non-selective ion conduction journal February 2018
Shifts in the selectivity filter dynamics cause modal gating in K+ channels journal January 2019
Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling journal November 2019
Long-range electrostatic effects in biomolecular simulations journal January 1997
Comparison of simple potential functions for simulating liquid water journal July 1983
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems journal June 1993
Finite representation of an infinite bulk system: Solvent boundary potential for computer simulations journal June 1994
Scalable molecular dynamics on CPU and GPU architectures with NAMD journal July 2020
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel journal December 2007
Importance of lipid-pore loop interface for potassium channel structure and function journal July 2013
Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state journal September 2013
Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating journal January 2014
Transmembrane allosteric coupling of the gates in a potassium channel journal December 2013
Hysteresis of KcsA potassium channel's activation– deactivation gating is caused by structural changes at the channel’s selectivity filter journal March 2017
Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation journal October 2017
Selectivity filter modalities and rapid inactivation of the hERG1 channel journal January 2020
Conformational changes upon gating of KirBac1.1 into an open-activated state revealed by solid-state NMR and functional assays journal January 2020
Selectivity filter ion binding affinity determines inactivation in a potassium channel journal November 2020
Clustering and Coupled Gating Modulate the Activity in KcsA, a Potassium Channel Model journal May 2006
Correlation between Charge Movement and Ionic Current during Slow Inactivation in Shaker K+ Channels journal November 1997
Functional Consequences of a Decreased Potassium Affinity in a Potassium Channel Pore journal February 1999
The Barium Site in a Potassium Channel by X-Ray Crystallography: Figure 1 journal February 2000
Cross Talk between Activation and Slow Inactivation Gates of Shaker Potassium Channels journal October 2006
Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations journal November 2011
Potassium-selective block of barium permeation through single KcsA channels journal September 2011
C-type inactivation of voltage-gated K+ channels: Pore constriction or dilation? journal January 2013
The conserved potassium channel filter can have distinct ion binding profiles: Structural analysis of rubidium, cesium, and barium binding in NaK2K journal July 2014
Ionic interactions of Ba 2+ blockades in the MthK K + channel journal July 2014
Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel journal August 2018
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel journal August 2021
Potassium blocks barium permeation through a calcium-activated potassium channel. journal November 1988
Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel. journal November 1988
Structural plasticity of the selectivity filter in a nonselective ion channel journal April 2021
K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions journal October 2020
Mechanism of C-type inactivation in the hERG potassium channel journal January 2021
A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin journal December 2020
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity journal April 1998
Structural and Thermodynamic Properties of Selective Ion Binding in a K+ Channel journal May 2007
Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels journal December 2013
Mechanism of activation at the selectivity filter of the KcsA K+ channel journal October 2017
The gating cycle of a K+ channel at atomic resolution journal November 2017
Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs journal August 2018

Similar Records

Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel
Journal Article · 2018 · Journal of General Physiology · OSTI ID:1462596

Mechanism for Selectivity-inactivation Coupling in KcsA Potassium Channels
Journal Article · 2011 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1041664

Inactivation in the potassium channel KcsA
Journal Article · 2019 · Journal of Structural Biology: X · OSTI ID:1543165

Related Subjects