skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Improved therapeutic index of an acidic pH-selective antibody

Journal Article · · MABS-Austin

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1861848
Journal Information:
MABS-Austin, Vol. 14, Issue (1)
Country of Publication:
United States
Language:
ENGLISH

References (48)

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. journal August 1995
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways journal August 2008
CTLA-4 can function as a negative regulator of T cell activation journal August 1994
Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells journal April 2013
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies journal April 2018
Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial journal May 2017
Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa journal March 2004
Lack of Fucose on Human IgG1 N -Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity journal May 2002
NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy journal January 2015
Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index journal October 2013
Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes journal February 2019
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer journal August 2019
VISTA is an acidic pH-selective ligand for PSGL-1 journal October 2019
Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment journal November 2019
Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches journal February 2021
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization journal October 2010
Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9 journal March 2012
The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics journal November 2013
A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display journal January 2015
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases journal April 2017
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells journal January 2021
T-cell regulation by CD28 and CTLA-4 journal December 2001
Biased activation of human T lymphocytes due to low extracellular pH is antagonized by B7/CD28 costimulation journal September 2001
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo journal January 1996
Extracellular pH modulating injectable gel for enhancing immune checkpoint inhibitor therapy journal December 2019
Targeting T Cell Co-receptors for Cancer Therapy journal May 2016
Variability in the pKa of histidine side-chains correlates with burial within proteins journal August 2002
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy journal July 2019
Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody journal November 2020
T-cells produce acidic niches in lymph nodes to suppress their own effector functions journal August 2020
Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation journal April 2017
Applications of pHLIP Technology for Cancer Imaging and Therapy journal July 2017
Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors journal March 2018
Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity journal April 2021
Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI: acidoCEST MRI Evaluates Extracellular Tumor pH journal November 2013
In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging journal September 2017
Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging journal February 2020
Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment journal December 2020
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation journal August 2020
A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells journal June 2015
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning journal July 2021
Overview of the CCP 4 suite and current developments journal March 2011
Data processing and analysis with the autoPROC toolbox journal March 2011
XDS journal January 2010
Scaling and assessment of data quality journal December 2005
Features and development of Coot journal March 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009