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T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Journal Article · · J. Biol. Chem.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1861841
Journal Information:
J. Biol. Chem., Journal Name: J. Biol. Chem. Journal Issue: (3) Vol. 298
Country of Publication:
United States
Language:
ENGLISH

References (36)

T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation journal September 2019
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer journal December 2016
Computational Alanine Scanning of Protein-Protein Interfaces journal February 2004
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC journal March 2009
A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins journal November 2019
Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor journal February 2014
Targeting a neoantigen derived from a common TP53 mutation journal March 2021
Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer journal May 2014
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations journal November 2014
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer journal February 2019
A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes journal December 2012
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants journal September 2021
Cancer Neoantigens journal April 2019
How tcrs bind Mhcs, Peptides, and Coreceptors journal April 2006
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer journal June 2018
The evolutionary history of 2,658 cancers journal February 2020
Adoptive cell transfer as personalized immunotherapy for human cancer journal April 2015
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
Toward a Shared Vision for Cancer Genomic Data journal September 2016
Randomized Selection Design Trial Evaluating CD8 + -Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma journal June 2013
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen journal June 2020
Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others journal September 2017
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal journal March 2013
Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope journal November 2017
TCR3d: The T cell receptor structural repertoire database journal June 2019
Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response journal September 2017
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer journal April 2017
Determination of atomic desolvation energies from the structures of crystallized proteins 1 1Edited by B. Honig journal April 1997
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D journal May 2020
Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers journal January 2019
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients journal May 2017
Likelihood-enhanced fast rotation functions journal February 2004
Neoantigen quality, not quantity journal August 2019
Lessons from the Cancer Genome journal March 2013

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