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Title: T cell receptors employ diverse strategies to target a p53 cancer neoantigen

Journal Article · · J. Biol. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
Journal Information:
J. Biol. Chem., Vol. 298, Issue (3)
Country of Publication:
United States

References (36)

Adoptive cell transfer as personalized immunotherapy for human cancer journal April 2015
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer journal December 2016
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer journal June 2018
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer journal April 2017
Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer journal May 2014
Randomized Selection Design Trial Evaluating CD8 + -Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma journal June 2013
Cancer Neoantigens journal April 2019
Neoantigen quality, not quantity journal August 2019
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D journal May 2020
Lessons from the Cancer Genome journal March 2013
The evolutionary history of 2,658 cancers journal February 2020
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal journal March 2013
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients journal May 2017
Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others journal September 2017
Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers journal January 2019
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer journal February 2019
Toward a Shared Vision for Cancer Genomic Data journal September 2016
Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations journal November 2014
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen journal June 2020
T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation journal September 2019
How tcrs bind Mhcs, Peptides, and Coreceptors journal April 2006
A flexible docking approach for prediction of T cell receptor-peptide-MHC complexes journal December 2012
Computational Alanine Scanning of Protein-Protein Interfaces journal February 2004
Determination of atomic desolvation energies from the structures of crystallized proteins 1 1Edited by B. Honig journal April 1997
Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC journal March 2009
Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor journal February 2014
Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope journal November 2017
Targeting a neoantigen derived from a common TP53 mutation journal March 2021
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Likelihood-enhanced fast rotation functions journal February 2004
Towards automated crystallographic structure refinement with phenix.refine journal March 2012
Features and development of Coot journal March 2010
A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins journal November 2019
Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response journal September 2017
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants journal September 2021
TCR3d: The T cell receptor structural repertoire database journal June 2019