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The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunother

Journal Article · · ACS Chem. Biol.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1861840
Journal Information:
ACS Chem. Biol., Journal Name: ACS Chem. Biol. Journal Issue: (3) Vol. 17
Country of Publication:
United States
Language:
ENGLISH

References (41)

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function journal October 2018
Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis journal January 1996
Substrate and Docking Interactions in Serine/Threonine Protein Kinases journal November 2007
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation journal November 2011
Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation journal June 2019
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors journal August 2007
Features and development of Coot journal March 2010
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer journal January 2019
Data processing and analysis with the autoPROC toolbox journal March 2011
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1 journal February 2021
Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK journal August 2015
Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development journal March 2000
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells journal October 2011
HPK1 Is Activated by Lymphocyte Antigen Receptors and Negatively Regulates AP-1 journal April 2000
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance journal August 2014
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes journal August 2002
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses journal November 2006
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes journal December 2007
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase journal October 1995
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies journal October 2020
Phaser crystallographic software journal July 2007
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension: GLK Co-crystal Structure with Aminopyrrolopyrimidine Inhibitor journal October 2016
The target landscape of clinical kinase drugs journal November 2017
A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase journal February 1997
HPK1 as a novel target for cancer immunotherapy journal April 2012
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo journal April 2019
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. journal September 1996
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response journal September 2009
Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling journal February 2015
Identification of Potent Reverse Indazole Inhibitors for HPK1 journal March 2021
Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2–induced fos gene transcription journal May 2003
A Novel Human STE20-related Protein Kinase, HGK, That Specifically Activates the c-Jun N-terminal Kinase Signaling Pathway journal January 1999
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds journal March 2021
Prostaglandin E2 Activates HPK1 Kinase Activity via a PKA-dependent Pathway journal November 2007
TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton journal October 1999
Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK) journal May 2001
Hematopoietic Progenitor Kinase 1 Is a Negative Regulator of Dendritic Cell Activation journal May 2009
Big opportunities for small molecules in immuno-oncology journal July 2015
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase journal September 1997
Functional interactions of HPK1 with adaptor proteins journal January 2005
Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling journal June 2001

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