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Title: Chromosome mapping of the human arrestin (SAG), {beta}-arrestin 2 (ARRB2), and {beta}-adrenergic receptor kinase 2 (ADRBK2) genes

Abstract

Two types of proteins play a major role in determining homologous desensitization of G-coupled receptors: {beta}-adrenergic receptor kinase ({beta}ARK), which phosphorylates the agonist-occupied receptor and its functional cofactor, {beta}-arrestin. Both {beta}ARK and {beta}-arrestin are members of multigene families. The family of G-protein-coupled receptor kinases includes rhodopsin kinase, {beta}ARK1, {beta}ARK2, IT11-A (GRK4), GRK5, and GRK6. The arrestin/{beta}-arrestin gene family includes arrestin (also known as S-antigen), {beta}-arrestin 1, and {beta}-arrestin 2. Here we report the chromosome mapping of the human genes for arrestin (SAG), {beta}arrestin 2 (ARRB2), and {beta}ARK2 (ADRBK2) by fluorescence in situ hybridization (FISH). FISH results confirmed the assignment of the gene coding for arrestin (SAG) to chromosome 2 and allowed us to refine its localization to band q37. The gene coding for {beta}-arrestin 2 (ARRB2) was mapped to chromosome 17p13 and that coding for {beta}ARK2 (ADRBK2) to chromosome 22q11. 17 refs., 1 fig.

Authors:
 [1]; ;  [2]
  1. Universita di Chiete (Italy)
  2. Istituto de Ricerche Farmacologiche, Santa Maria Imbaro (Italy) [and others
Publication Date:
OSTI Identifier:
186079
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 23; Journal Issue: 1; Other Information: PBD: 1 Sep 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOME 2; GENETIC MAPPING; HUMAN CHROMOSOME 17; HUMAN CHROMOSOME 22; GENES; ANTIGENS; SYMPATHOMIMETICS; RECEPTORS; PHOSPHOTRANSFERASES; PROTEINS; DNA HYBRIDIZATION; FLUORESCENCE; RHODOPSIN

Citation Formats

Calabrese, G., Sallese, M., and Stornaiuolo, A. Chromosome mapping of the human arrestin (SAG), {beta}-arrestin 2 (ARRB2), and {beta}-adrenergic receptor kinase 2 (ADRBK2) genes. United States: N. p., 1994. Web. doi:10.1006/geno.1994.1497.
Calabrese, G., Sallese, M., & Stornaiuolo, A. Chromosome mapping of the human arrestin (SAG), {beta}-arrestin 2 (ARRB2), and {beta}-adrenergic receptor kinase 2 (ADRBK2) genes. United States. doi:10.1006/geno.1994.1497.
Calabrese, G., Sallese, M., and Stornaiuolo, A. Thu . "Chromosome mapping of the human arrestin (SAG), {beta}-arrestin 2 (ARRB2), and {beta}-adrenergic receptor kinase 2 (ADRBK2) genes". United States. doi:10.1006/geno.1994.1497.
@article{osti_186079,
title = {Chromosome mapping of the human arrestin (SAG), {beta}-arrestin 2 (ARRB2), and {beta}-adrenergic receptor kinase 2 (ADRBK2) genes},
author = {Calabrese, G. and Sallese, M. and Stornaiuolo, A.},
abstractNote = {Two types of proteins play a major role in determining homologous desensitization of G-coupled receptors: {beta}-adrenergic receptor kinase ({beta}ARK), which phosphorylates the agonist-occupied receptor and its functional cofactor, {beta}-arrestin. Both {beta}ARK and {beta}-arrestin are members of multigene families. The family of G-protein-coupled receptor kinases includes rhodopsin kinase, {beta}ARK1, {beta}ARK2, IT11-A (GRK4), GRK5, and GRK6. The arrestin/{beta}-arrestin gene family includes arrestin (also known as S-antigen), {beta}-arrestin 1, and {beta}-arrestin 2. Here we report the chromosome mapping of the human genes for arrestin (SAG), {beta}arrestin 2 (ARRB2), and {beta}ARK2 (ADRBK2) by fluorescence in situ hybridization (FISH). FISH results confirmed the assignment of the gene coding for arrestin (SAG) to chromosome 2 and allowed us to refine its localization to band q37. The gene coding for {beta}-arrestin 2 (ARRB2) was mapped to chromosome 17p13 and that coding for {beta}ARK2 (ADRBK2) to chromosome 22q11. 17 refs., 1 fig.},
doi = {10.1006/geno.1994.1497},
journal = {Genomics},
number = 1,
volume = 23,
place = {United States},
year = {1994},
month = {9}
}