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Method and apparatus for ion mobility separations utilizing alternating current waveforms

Patent ·
OSTI ID:1860211
; ; ;

Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE; National Institute of Health (NIH)
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
11,209,393
Application Number:
16/404,472
OSTI ID:
1860211
Country of Publication:
United States
Language:
English

References (8)

Infected aortic aneurysms presenting with night sweats despite negative blood cultures journal November 2014
A Special Flare-CME Event on April 21, 2002 journal September 2004
Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry: Dynamic Switching in Structures for Lossless Ion Manipulations journal September 2014
Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations journal January 2016
Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations journal April 2017
Lipid and Glycolipid Isomer Analyses Using Ultra-High Resolution Ion Mobility Spectrometry Separations journal January 2017
Characterization of Ion Dynamics in Structures for Lossless Ion Manipulations journal September 2014
Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations journal October 2015

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