Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and

Journal Article · · ACS Infect. Dis.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIAID
OSTI ID:
1856383
Journal Information:
ACS Infect. Dis., Journal Name: ACS Infect. Dis. Journal Issue: (3) Vol. 8
Country of Publication:
United States
Language:
ENGLISH

References (54)

Species Specificity of the NS1 Protein of Influenza B Virus: NS1 BINDS ONLY HUMAN AND NON-HUMAN PRIMATE UBIQUITIN-LIKE ISG15 PROTEINS journal January 2010
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases journal December 2019
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity journal July 2020
Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis journal February 2015
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme journal March 2006
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence journal November 2015
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States journal June 2020
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement journal January 2019
Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease journal May 2020
Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes journal April 2020
Bats Are Natural Reservoirs of SARS-Like Coronaviruses journal October 2005
How ISG15 combats viral infection journal September 2020
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Phaser crystallographic software journal July 2007
SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020 journal June 2020
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus journal August 2007
Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling journal April 2009
Cross‐species transmission of the newly identified coronavirus 2019‐nCoV journal February 2020
Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins journal September 2016
Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein journal March 2010
Mechanisms and enzymes involved in SARS coronavirus genome expression journal September 2003
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 journal August 2020
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion journal September 2021
ISG15: It's Complicated journal October 2019
Ubiquitination in the antiviral immune response journal May 2015
An Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular Diagnostics in Benin, Western Africa journal February 2021
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity journal November 2005
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways journal July 2005
Interferon-inducible antiviral effectors journal July 2008
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease journal September 2017
Review of Bats and SARS journal January 2006
Overview of the CCP 4 suite and current developments journal March 2011
Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay journal December 2020
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme journal May 2015
Adventures in Drug-like Chemistry Space: From Oxetanes to Spiroazetidines and Beyond! journal August 2014
Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins journal March 2020
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions journal October 2015
Dilemmas With Rotavirus Vaccine: The Neonate and Immunocompromised journal January 2019
The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds journal March 2015
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease journal May 2016
Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species journal June 2017
Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus journal August 2014
Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus journal September 2017
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases journal March 2014
Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors journal January 2014
The state of vaccine safety science: systematic reviews of the evidence journal May 2020
Thiopurine Analogue Inhibitors of Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease, a Deubiquitinating and deISGylating Enzyme journal February 2009
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication journal October 2008
Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species journal July 2016
Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation journal July 2010
Development and optimization of a direct plaque assay for human and avian metapneumoviruses journal October 2012