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Title: Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain

Journal Article · · Protein Sci.
DOI:https://doi.org/10.1002/pro.4268· OSTI ID:1855483

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science
OSTI ID:
1855483
Journal Information:
Protein Sci., Vol. 31, Issue (3)
Country of Publication:
United States
Language:
ENGLISH

References (60)

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide journal February 2007
Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors journal September 2016
Alpha-synuclein oligomers: a new hope journal August 2017
Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS) journal July 2017
Amyloidosis and Alzheimer’s disease journal December 2002
Selective vulnerability in neurodegenerative diseases journal September 2018
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors journal October 2006
Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update journal December 2014
From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases journal March 2015
Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration journal July 2011
Native Ion Mobility-Mass Spectrometry Reveals the Formation of β-Barrel Shaped Amyloid-β Hexamers in a Membrane-Mimicking Environment journal May 2019
Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments journal September 2016
Atomic View of a Toxic Amyloid Small Oligomer journal March 2012
The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril journal February 2017
Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels journal January 2016
Characterizing TDP-43 307–319 Oligomeric Assembly: Mechanistic and Structural Implications Involved in the Etiology of Amyotrophic Lateral Sclerosis journal August 2019
The spatial patterns of prion protein deposits in Creutzfeldt–Jakob disease: comparison with β-amyloid deposits in Alzheimer's disease journal January 2001
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals journal July 2008
Pathology of Neurodegenerative Diseases journal January 2017
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts journal October 1997
Central and Peripheral Circadian Clocks in Mammals journal July 2012
Neuroanatomy of the extended circadian rhythm system journal May 2013
Resilience in the suprachiasmatic nucleus: Implications for aging and Alzheimer's disease journal May 2021
Pathologic Evaluation of the Human Suprachiasmatic Nucleus in Severe Dementia journal January 1999
Sleep and Alzheimer's disease: A pivotal role for the suprachiasmatic nucleus journal August 2018
Basis of Robustness and Resilience in the Suprachiasmatic Nucleus: Individual Neurons Form Nodes in Circuits that Cycle Daily journal September 2009
Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents journal May 2004
Neuropeptide-mediated calcium signaling in the suprachiasmatic nucleus network: Peptides and Ca2+ signaling in the SCN journal October 2010
Direct cellular peptidomics of hypothalamic neurons journal October 2011
Suprachiasmatic nucleus neurons display endogenous resistance to excitotoxicity journal February 2010
Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques journal January 2009
Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease journal January 2010
Cytotoxicity of α-Helical, Staphylococcus aureus PSMα3 Investigated by Post-Ion-Mobility Dissociation Mass Spectrometry journal July 2020
Selective host–guest chemistry, self-assembly and conformational preferences of m -xylene macrocycles probed by ion-mobility spectrometry mass spectrometry journal January 2020
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease journal June 2009
Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation journal December 2010
The expanding amyloid family: Structure, stability, function, and pathogenesis journal September 2021
Structural Studies of Amyloid Proteins at the Molecular Level journal June 2017
Structure of a Multifunctional Protein journal March 2001
Structural studies on human muscle fatty acid binding protein at 1.4 å resolution: binding interactions with three C18 fatty acids journal June 1994
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy journal January 2013
Inter-subunit rotation and elastic power transmission in F 0 F 1 -ATPase journal August 2001
Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations journal March 2018
Mass spectrometry of intact membrane protein complexes journal March 2013
Structural Information from Ion Mobility Measurements:  Effects of the Long-Range Potential journal January 1996
An exact hard-spheres scattering model for the mobilities of polyatomic ions journal October 1996
Mass spectrometry-based discovery of circadian peptides journal August 2008
Quantitative Peptidomics for Discovery of Circadian-Related Peptides from the Rat Suprachiasmatic Nucleus journal January 2013
Endogenous Peptide Discovery of the Rat Circadian Clock journal February 2010
Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease journal March 2017
Tubulin Polymerization Promoting Protein Affects the Circadian Timing System in C57Bl/6 Mice journal January 2021
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH journal March 1996
Rat Brain Glyceraldehyde-3-Phosphate Dehydrogenase Interacts with the Recombinant Cytoplasmic Domain of Alzheimer's ?-Amyloid Precursor Protein journal May 1993
Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration journal April 2010
Synaptic Proteins in Alzheimer's Disease journal January 2002
Role of Phenylalanine 20 in Alzheimer's Amyloid β-Peptide (1-42)-Induced Oxidative Stress and Neurotoxicity journal November 2004
Aromaticity of Phenylalanine Residues Is Essential for Amyloid Formation by Alzheimer’s Amyloid β-Peptide journal January 2017
Role of Aromatic Side Chains in Amyloid β-Protein Aggregation journal October 2012
Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3 journal March 2015
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau journal June 2020