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U.S. Department of Energy
Office of Scientific and Technical Information
 

Computational design of a synthetic PD-1 agonist

Journal Article · · Proc. Natl. Acad. Sci. USA
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH); OTHER
OSTI ID:
1854218
Journal Information:
Proc. Natl. Acad. Sci. USA, Vol. 118, Issue (29)
Country of Publication:
United States
Language:
ENGLISH

References (47)

The PD-1/PD-Ls pathway and autoimmune diseases July 2014
Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1 December 2015
A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery November 2019
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 May 2012
Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice March 2000
Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells October 2003
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice January 2001
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor August 1999
Tissue expression of PD-L1 mediates peripheral T cell tolerance April 2006
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans October 2002
Meta-analysis of genetic polymorphisms in programmed cell death 1: Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility June 2014
A PD-1 polymorphism is associated with disease progression in multiple sclerosis May 2005
SnapShot: Immune Checkpoint Inhibitors June 2017
Immune Checkpoints as Therapeutic Targets in Autoimmunity October 2018
Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1 January 2003
Protective effects of Fc-fused PD-L1 on two different animal models of colitis June 2014
The effects of PDL-Ig on collagen-induced arthritis December 2009
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity August 2020
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors February 2008
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2 July 2008
Accurate de novo design of hyperstable constrained peptides September 2016
Rosetta3: An Object-Oriented Software Suite for the Simulation and Design of Macromolecules January 2011
Proof of principle for epitope-focused vaccine design February 2014
Massively parallel de novo protein design for targeted therapeutics September 2017
Prediction of Protein Structural Features from Sequence Data Based on Shannon Entropy and Kolmogorov Complexity April 2015
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors September 2011
Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin February 2012
De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity May 2016
Polypeptide chain collapse and protein folding March 2013
Effect of β-sheet propensity on peptide aggregation April 2009
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development December 2015
Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma September 2017
Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma March 2020
Adoptive Transfer of Regulatory T Cells as a Promising Immunotherapy for the Treatment of Multiple Sclerosis October 2019
Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities November 2014
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions October 2015
Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope September 2010
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis May 2002
Isolating and engineering human antibodies using yeast surface display July 2006
Immobilized protein ZZ, an affinity tool for immunoglobulin isolation and immunological experimentation September 2006
XDS January 2010
Phaser crystallographic software July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
Substructure solution with SHELXD September 2002
Features and development of Coot March 2010
Towards automated crystallographic structure refinement with phenix.refine March 2012
Apo Structure of the De Novo PD-1 Binding Miniprotein GR918.2 January 2020

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