skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes

Journal Article · · J. Biol. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1847720
Journal Information:
J. Biol. Chem., Vol. 298, Issue (2)
Country of Publication:
United States
Language:
ENGLISH

References (37)

Targeting cancer metabolism: a therapeutic window opens journal August 2011
Targeting Metabolism for Cancer Therapy journal September 2017
Tumor Cell Metabolism: Cancer's Achilles' Heel journal June 2008
Targeting Cancer Metabolism journal October 2012
On the Origin of Cancer Cells journal February 1956
Hallmarks of Cancer: The Next Generation journal March 2011
Glutamine addiction: a new therapeutic target in cancer journal August 2010
Targeting amino acid metabolism for cancer therapy journal May 2017
Identifying strategies to target the metabolic flexibility of tumours journal April 2020
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport journal November 2014
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation journal September 2010
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer journal February 2014
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer journal November 2009
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer journal October 2019
Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth journal October 2012
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization journal January 2019
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism journal February 2009
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy journal April 2016
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer journal March 2021
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion journal November 2019
Mechanistic Basis of Glutaminase Activation journal September 2016
ACTIVATORS and INHIBITORS OF BRAIN GLUTAMINASE journal June 1969
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled journal January 2020
Correlation between activation and dimer formation of rat renal phosphate-dependent glutaminase. journal March 1977
Properties of rat renal phosphate-dependent glutaminase coupled to Sepharose. Evidence that dimerization is essential for activation journal March 1981
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) journal August 2007
Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase journal September 2003
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism journal January 2012
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells journal December 2014
On the nature of allosteric transitions: A plausible model journal May 1965
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor journal August 2013
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism journal April 2012
Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA) journal January 2014
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators journal April 2017
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Coot model-building tools for molecular graphics journal November 2004