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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

Journal Article · · Nat. Commun.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; UNIVERSITY; USDA
OSTI ID:
1847716
Journal Information:
Nat. Commun., Vol. 13
Country of Publication:
United States
Language:
ENGLISH

References (55)

Pathophysiology of Inflammatory Bowel Diseases journal December 2020
Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review journal January 2012
Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015 journal October 2016
National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States journal April 2014
Management of Crohn Disease: A Review journal January 2021
Inflammation and Colon Cancer journal May 2010
Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses journal September 2019
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome journal February 2015
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice journal June 2012
Triclosan exposure, transformation, and human health effects journal November 2017
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice journal May 2018
Triclosan, a common antimicrobial ingredient, on gut microbiota and gut health journal November 2018
Determination of triclosan metabolites by using in-source fragmentation from high-performance liquid chromatography/negative atmospheric pressure chemical ionization ion trap mass spectrometry: In-source fragmentation of triclosan and its metabolites journal June 2010
Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome journal June 2016
Triclosan: A Widespread Environmental Toxicant with Many Biological Effects journal January 2016
Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones journal November 2009
On the Need and Speed of Regulating Triclosan and Triclocarban in the United States journal March 2014
Urinary Concentrations of Triclosan in the U.S. Population: 2003–2004 journal March 2008
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice journal February 2008
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 journal March 2010
Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved journal November 2019
Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation journal March 2020
Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases journal January 2019
Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases journal October 2019
Pharmacologic Targeting of Bacterial β-Glucuronidase Alleviates Nonsteroidal Anti-Inflammatory Drug-Induced Enteropathy in Mice journal February 2012
An Atlas of β-Glucuronidases in the Human Intestinal Microbiome journal July 2017
Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity journal September 2015
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy journal March 2020
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme journal November 2010
Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure journal August 2019
Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome journal March 2019
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling journal October 2019
Activity-based probes for functional interrogation of retaining β-glucuronidases journal June 2017
Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception journal July 2018
Glucuronides in the gut: Sugar-driven symbioses between microbe and host journal April 2017
Effect of altered gastric emptying and gastrointestinal motility on metformin absorption: Metformin absorption with altered gastrointestinal transit journal October 2000
Effects of Food on Clinical Pharmacokinetics journal January 1999
The gut microbiota: a major player in the toxicity of environmental pollutants? journal May 2016
Experimental Models of Inflammatory Bowel Diseases journal March 2015
The Gut Microbiota Impact Cancer Etiology through “Phase IV Metabolism” of Xenobiotics and Endobiotics journal July 2020
Determination of Free and Conjugated Forms of Bisphenol A in Human Urine and Serum by Liquid Chromatography–Tandem Mass Spectrometry journal April 2012
Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis journal February 2017
The PRIDE database and related tools and resources in 2019: improving support for quantification data journal November 2018
Microbiota fingerprints lose individually identifying features over time journal January 2017
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification journal November 2008
An integrated catalog of reference genes in the human gut microbiome journal July 2014
UniProt: the Universal Protein knowledgebase journal January 2004
Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis journal October 2018
The Phyre2 web portal for protein modeling, prediction and analysis journal May 2015
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Features and development of Coot journal March 2010
Estimation of Protein Secondary Structure from Circular Dichroism Spectra: Comparison of CONTIN, SELCON, and CDSSTR Methods with an Expanded Reference Set journal December 2000
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 journal July 2019
phytools: an R package for phylogenetic comparative biology (and other things): phytools: R package journal December 2011
ggplot2 book January 2009