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U.S. Department of Energy
Office of Scientific and Technical Information
 

Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA

Journal Article · · J. Mol. Biol.
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1847713
Journal Information:
J. Mol. Biol., Vol. 433, Issue (21)
Country of Publication:
United States
Language:
ENGLISH

References (39)

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses June 2004
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates November 2006
Master sensors of pathogenic RNA – RIG-I like receptors November 2013
Novel interferonopathies associated with mutations in RIG-I like receptors June 2016
RIG-I-Like Receptors and Type I Interferonopathies May 2017
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery December 2010
5'-Triphosphate RNA Is the Ligand for RIG-I November 2006
Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus July 2009
RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection February 2010
RIG-I in RNA virus recognition May 2015
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets November 2012
Generation of high-affinity DNA aptamers using an expanded genetic alphabet April 2013
Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor January 2014
The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I February 2008
The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain August 2010
Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I November 2012
Parts, assembly and operation of the RIG-I family of motors April 2014
The Thermodynamic Basis for Viral RNA Detection by the RIG-I Innate Immune Sensor December 2012
Structural basis of RNA recognition and activation by innate immune receptor RIG-I September 2011
A structure-based model of RIG-I activation November 2012
Embracing proteins: structural themes in aptamer–protein complexes February 2016
Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents January 2014
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling October 2017
Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I June 2010
Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I January 2016
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor July 2015
Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis August 2014
Crystal structure of NF- B (p50)2 complexed to a high-affinity RNA aptamer July 2003
XDS January 2010
Overview of the CCP 4 suite and current developments March 2011
Phaser.MRage : automated molecular replacement October 2013
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
RCrane : semi-automated RNA model building July 2012
Coot model-building tools for molecular graphics November 2004
Towards automated crystallographic structure refinement with phenix.refine March 2012
Site-specific introduction of functional groups into phosphodiester oligodeoxynucleotides and their thermal stability and nuclease- resistance properties July 1997
Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridines May 2003
Rapid chromatographic technique for preparative separations with moderate resolution July 1978
Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one February 1989

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