skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Inhibition of bacterial FMN transferase: A potential avenue for countering antimicrobial resistance

Journal Article · · Protein Sci.
DOI:· OSTI ID:1847695

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
Journal Information:
Protein Sci., Vol. 31, Issue (2)
Country of Publication:
United States

References (33)

Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein journal May 2015
Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen journal October 2016
The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis journal February 2013
A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria journal September 2018
Alternative Pyrimidine Biosynthesis Protein ApbE Is a Flavin Transferase Catalyzing Covalent Attachment of FMN to a Threonine Residue in Bacterial Flavoproteins journal April 2013
Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes journal November 2010
Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review journal March 2018
The sodium pumping NADH:quinone oxidoreductase (Na+-NQR), a unique redox-driven ion pump journal July 2014
Sodium-translocating NADH:quinone oxidoreductase as a redox-driven ion pump journal June 2010
Biophysical and Biochemical Characterization of TP0037, a d -Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum journal October 2020
Succinate Secreted by Trypanosoma brucei Is Produced by a Novel and Unique Glycosomal Enzyme, NADH-dependent Fumarate Reductase journal July 2002
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase journal December 2014
Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm journal December 2015
Energy conservation involving 2 respiratory circuits journal December 2019
Inhibitors of a Na+-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function journal September 2020
Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria journal December 2019
Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages journal July 2019
Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete journal July 1998
Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020 journal December 2020
The Role of China in the Global Spread of the Current Cholera Pandemic journal March 2015
Multiple-Antibiotic Resistance of Enterococcus faecalis and Enterococcus faecium from Cecal Contents in Broiler Chicken and Turkey Flocks Slaughtered in Canada and Plasmid Colocalization of tetO and ermB Genes journal October 2011
Novel Targets of Antimicrobial Therapies journal March 2016
Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria journal December 2017
Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins journal November 2017
Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase journal January 2021
Protein Identification and Analysis Tools on the ExPASy Server book January 2005
On the acquisition and analysis of microscale thermophoresis data journal March 2016
Calculations and Publication-Quality Illustrations for Analytical Ultracentrifugation Data book January 2015
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
On the treatment of negative intensity observations journal July 1978
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Phaser crystallographic software journal July 2007
Coot model-building tools for molecular graphics journal November 2004