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Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module

Journal Article · · Bioorg. Med. Chem. Lett.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1847127
Journal Information:
Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Vol. 60
Country of Publication:
United States
Language:
ENGLISH

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Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins journal August 2020
Systemic immunoglobulin light chain amyloidosis journal October 2018
Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains journal January 2021
Infusion of Light Chains From Patients With Cardiac Amyloidosis Causes Diastolic Dysfunction in Isolated Mouse Hearts journal October 2001
Identification of Chemical and Pharmacological Chaperones for Correction of Trafficking-Deficient Mutant Cyclic Nucleotide–Gated A3 Channels journal April 2021
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Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish journal July 2013
The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains journal October 2016
Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity journal December 2017
Treatment patterns and outcome following initial relapse or refractory disease in patients with systemic light chain amyloidosis journal April 2017
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Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38  MAPK pathway journal February 2010
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Stabilization of amyloidogenic immunoglobulin light chains by small molecules journal April 2019
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