Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS[superscript G12D] Inhibitor

Wang, Xiaolun; Allen, Shelley; Blake, James F.; Bowcut, Vickie; Briere, David M.; Calinisan, Andrew; Dahlke, Joshua R.; Fell, Jay B.; Fischer, John P.; Gunn, Robin J.; Hallin, Jill; Laguer, Jade; Lawson, J.David; Medwid, James; Newhouse, Brad; Nguyen, Phong; O?Leary, Jacob M.; Olson, Peter; Pajk, Spencer; Rahbaek, Lisa; Rodriguez, Mareli; Smith, Christopher R.; Tang, Tony P.; Thomas, Nicole C.; Vanderpool, Darin; Vigers, Guy P.; Christensen, James G.; Marx, Matthew A.

doi:10.1021/acs.jmedchem.1c01688

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS[superscript G12D] Inhibitor

Journal Article · 01 January 2022 · J. Med. Chem.

DOI:https://doi.org/10.1021/acs.jmedchem.1c01688· OSTI ID:1847119

Wang, Xiaolun; Allen, Shelley; Blake, James F.; Bowcut, Vickie; Briere, David M.; Calinisan, Andrew; Dahlke, Joshua R.; Fell, Jay B.; Fischer, John P.; Gunn, Robin J.; Hallin, Jill; Laguer, Jade; Lawson, J.David; Medwid, James; Newhouse, Brad; Nguyen, Phong; O?Leary, Jacob M.; Olson, Peter; Pajk, Spencer; Rahbaek, Lisa more »

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1847119

Journal Information:: J. Med. Chem., Vol. 65, Issue (4)

Country of Publication:: United States

Language:: ENGLISH

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