Diversity Considerations in HIV-1 Vaccine Selection
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June 2002 |
Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines
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March 2018 |
Multiple roles for HIV broadly neutralizing antibodies
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October 2019 |
HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure
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May 2018 |
Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition
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January 2019 |
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
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November 2011 |
Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
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September 2009 |
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth
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November 2016 |
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
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July 2010 |
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
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June 2015 |
Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function
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July 2012 |
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
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September 2012 |
Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding
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September 2016 |
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope
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March 2018 |
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
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May 2016 |
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
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June 2018 |
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization
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July 2019 |
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
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December 2019 |
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
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October 2019 |
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
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March 2011 |
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
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January 2014 |
Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm
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May 2009 |
Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
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September 2018 |
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
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April 2013 |
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
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March 2009 |
Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies
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November 2009 |
Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
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January 2010 |
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
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July 2011 |
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
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September 2010 |
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
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August 2011 |
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens
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December 2009 |
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
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September 2012 |
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
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March 2013 |
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
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February 2018 |
The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes
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March 1996 |
Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline
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January 2014 |
Advancing an HIV vaccine; advancing vaccinology
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December 2018 |
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice
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June 2015 |
Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies
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August 2018 |
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
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June 2015 |
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
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September 2016 |
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
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March 2013 |
Deep mutational scanning: a new style of protein science
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July 2014 |
Plasmid-based one-pot saturation mutagenesis
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October 2016 |
Yeast surface display for screening combinatorial polypeptide libraries
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June 1997 |
Isolating and engineering human antibodies using yeast surface display
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July 2006 |
Functional interrogation and mining of natively paired human VH:VL antibody repertoires
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January 2018 |
SORTCERY—A High–Throughput Method to Affinity Rank Peptide Ligands
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June 2015 |
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
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June 2015 |
Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen
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February 2020 |
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
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January 2017 |
High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis
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June 2018 |
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation
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May 2017 |
Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10
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September 2014 |
Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV
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July 2018 |
Effects on interaction kinetics of mutations at the VH-VL interface of Fabs depend on the structural context
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January 2000 |
Structural Consequences of Target Epitope-directed Functional Alteration of an Antibody
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July 2003 |
The role of interface framework residues in determining antibody VH/VL interaction strength and antigen-binding affinity
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May 2006 |
Critical contribution of VH-VL interaction to reshaping of an antibody: The case of humanization of anti-lysozyme antibody, HyHEL-10
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February 2008 |
Role of the Domain-Domain Interaction in the Construction of the Antigen Combining Site
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October 1994 |
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
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August 2019 |
Thermodynamic stability contributes to immunoglobulin specificity
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May 2014 |
Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability
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March 2017 |
Protein Folding Stability Can Determine the Efficiency of Escape from Endoplasmic Reticulum Quality Control
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July 1998 |
Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves
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December 2016 |
Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing
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August 2015 |
Precise and Efficient Antibody Epitope Determination through Library Design, Yeast Display and Next-Generation Sequencing
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March 2015 |
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development
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June 2018 |
Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
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July 2019 |
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
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April 2016 |
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
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July 2010 |
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1
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July 2014 |
Scalable molecular dynamics with NAMD
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January 2005 |
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles
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August 2012 |
CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling
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August 2011 |