Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-n

Chen, Xuejun; Zhou, Tongqing; Schmidt, Stephen D.; Duan, Hongying; Cheng, Cheng; Chuang, Gwo-Yu; Gu, Ying; Louder, Mark K.; Lin, Bob C.; Shen, Chen-Hsiang; Sheng, Zizhang; Zheng, Michelle X.; Doria-Rose, Nicole A.; Joyce, M. Gordon; Shapiro, Lawrence; Tian, Ming; Alt, Frederick W.; Kwong, Peter D.; Mascola, John R.

doi:10.1016/j.immuni.2020.12.014

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-n

Journal Article · 01 February 2021 · Immunity

DOI:https://doi.org/10.1016/j.immuni.2020.12.014· OSTI ID:1847111

Chen, Xuejun; Zhou, Tongqing; Schmidt, Stephen D.; Duan, Hongying; Cheng, Cheng; Chuang, Gwo-Yu; Gu, Ying; Louder, Mark K.; Lin, Bob C.; Shen, Chen-Hsiang; Sheng, Zizhang; Zheng, Michelle X.; Doria-Rose, Nicole A.; Joyce, M. Gordon; Shapiro, Lawrence; Tian, Ming; Alt, Frederick W.; Kwong, Peter D.; Mascola, John R.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH)

OSTI ID:: 1847111

Journal Information:: Immunity, Vol. 54, Issue (2)

Country of Publication:: United States

Language:: ENGLISH

References (50)

Recent developments in the PHENIX software for automated crystallographic structure determination Adams, Paul D.; Gopal, Kreshna; Grosse-Kunstleve, Ralf W. Journal of Synchrotron Radiation, Vol. 11, Issue 1 https://doi.org/10.1107/S0909049503024130	journal	November 2003
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis Brochet, X.; Lefranc, M. -P.; Giudicelli, V. Nucleic Acids Research, Vol. 36, Issue Web Server https://doi.org/10.1093/nar/gkn316	journal	May 2008
Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting Cheng, Cheng; Xu, Kai; Kong, Rui PLOS ONE, Vol. 14, Issue 4 https://doi.org/10.1371/journal.pone.0215163	journal	April 2019
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice Dosenovic, Pia; von Boehmer, Lotta; Escolano, Amelia Cell, Vol. 161, Issue 7 https://doi.org/10.1016/j.cell.2015.06.003	journal	June 2015
Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies Duan, Hongying; Chen, Xuejun; Boyington, Jeffrey C. Immunity, Vol. 49, Issue 2 https://doi.org/10.1016/j.immuni.2018.07.005	journal	August 2018
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice Escolano, Amelia; Steichen, Jon M.; Dosenovic, Pia Cell, Vol. 166, Issue 6 https://doi.org/10.1016/j.cell.2016.07.030	journal	September 2016
PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4 Falkowska, Emilia; Ramos, Alejandra; Feng, Yu Journal of Virology, Vol. 86, Issue 8 https://doi.org/10.1128/JVI.06973-11	journal	February 2012
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges Gautam, Rajeev; Nishimura, Yoshiaki; Pegu, Amarendra Nature, Vol. 533, Issue 7601 https://doi.org/10.1038/nature17677	journal	April 2016
Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization Georgiev, I. S.; Doria-Rose, N. A.; Zhou, T. Science, Vol. 340, Issue 6133 https://doi.org/10.1126/science.1233989	journal	May 2013
cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence Guo, Yicheng; Chen, Kevin; Kwong, Peter D. Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.02365	journal	October 2019
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques Hessell, Ann J.; Jaworski, J. Pablo; Epson, Erin Nature Medicine, Vol. 22, Issue 4 https://doi.org/10.1038/nm.4063	journal	March 2016
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth Huang, Jinghe; Kang, Byong H.; Ishida, Elise Immunity, Vol. 45, Issue 5 https://doi.org/10.1016/j.immuni.2016.10.027	journal	November 2016
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors Jardine, J.; Julien, J. -P.; Menis, S. Science, Vol. 340, Issue 6133 https://doi.org/10.1126/science.1234150	journal	March 2013
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen Jardine, J. G.; Kulp, D. W.; Havenar-Daughton, C. Science, Vol. 351, Issue 6280 https://doi.org/10.1126/science.aad9195	journal	March 2016
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen Jardine, J. G.; Ota, T.; Sok, D. Science, Vol. 349, Issue 6244 https://doi.org/10.1126/science.aac5894	journal	June 2015
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design Jardine, Joseph G.; Sok, Devin; Julien, Jean-Philippe PLOS Pathogens, Vol. 12, Issue 8 https://doi.org/10.1371/journal.ppat.1005815	journal	August 2016
Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains Joyce, M. Gordon; Georgiev, Ivelin S.; Yang, Yongping Cell Reports, Vol. 21, Issue 10 https://doi.org/10.1016/j.celrep.2017.11.016	journal	December 2017
Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor Kong, Leopold; Ju, Bin; Chen, Yajing Immunity, Vol. 44, Issue 4 https://doi.org/10.1016/j.immuni.2016.03.006	journal	April 2016
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization Kong, Rui; Duan, Hongying; Sheng, Zizhang Cell, Vol. 178, Issue 3 https://doi.org/10.1016/j.cell.2019.06.030	journal	July 2019
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env Do Kwon, Young; Pancera, Marie; Acharya, Priyamvada Nature Structural & Molecular Biology, Vol. 22, Issue 7 https://doi.org/10.1038/nsmb.3051	journal	June 2015
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Kwong, Peter D.; Wyatt, Richard; Robinson, James Nature, Vol. 393, Issue 6686 https://doi.org/10.1038/31405	journal	June 1998
Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies Li, M.; Gao, F.; Mascola, J. R. Journal of Virology, Vol. 79, Issue 16 https://doi.org/10.1128/JVI.79.16.10108-10125.2005	journal	July 2005
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice McGuire, Andrew T.; Gray, Matthew D.; Dosenovic, Pia Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms10618	journal	February 2016
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies McGuire, Andrew T.; Hoot, Sam; Dreyer, Anita M. The Journal of Experimental Medicine, Vol. 210, Issue 4 https://doi.org/10.1084/jem.20122824	journal	March 2013
Combination therapy with anti-HIV-1 antibodies maintains viral suppression Mendoza, Pilar; Gruell, Henning; Nogueira, Lilian Nature, Vol. 561, Issue 7724 https://doi.org/10.1038/s41586-018-0531-2	journal	September 2018
Structure and immune recognition of trimeric pre-fusion HIV-1 Env Pancera, Marie; Zhou, Tongqing; Druz, Aliaksandr Nature, Vol. 514, Issue 7523 https://doi.org/10.1038/nature13808	journal	October 2014
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor Pegu, A.; Yang, Z. -y.; Boyington, J. C. Science Translational Medicine, Vol. 6, Issue 243 https://doi.org/10.1126/scitranslmed.3008992	journal	July 2014
Full-length RNA-seq from single cells using Smart-seq2 Picelli, Simone; Faridani, Omid R.; Björklund, Åsa K. Nature Protocols, Vol. 9, Issue 1 https://doi.org/10.1038/nprot.2014.006	journal	January 2014
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1 Sarzotti-Kelsoe, Marcella; Bailer, Robert T.; Turk, Ellen Journal of Immunological Methods, Vol. 409 https://doi.org/10.1016/j.jim.2013.11.022	journal	July 2014
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption Scheid, Johannes F.; Horwitz, Joshua A.; Bar-On, Yotam Nature, Vol. 535, Issue 7613 https://doi.org/10.1038/nature18929	journal	June 2016
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding Scheid, J. F.; Mouquet, H.; Ueberheide, B. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207227	journal	July 2011
SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts Schramm, Chaim A.; Sheng, Zizhang; Zhang, Zhenhai Frontiers in Immunology, Vol. 7 https://doi.org/10.3389/fimmu.2016.00372	journal	September 2016
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation Sheng, Zizhang; Schramm, Chaim A.; Kong, Rui Frontiers in Immunology, Vol. 8 https://doi.org/10.3389/fimmu.2017.00537	journal	May 2017
Clustal Omega for making accurate alignments of many protein sequences: Clustal Omega for Many Protein Sequences Sievers, Fabian; Higgins, Desmond G. Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3290	journal	October 2017
A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans Sok, Devin; Pauthner, Matthias; Briney, Bryan Immunity, Vol. 45, Issue 1 https://doi.org/10.1016/j.immuni.2016.06.026	journal	July 2016
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G Stewart-Jones, Guillaume B. E.; Soto, Cinque; Lemmin, Thomas Cell, Vol. 165, Issue 4 https://doi.org/10.1016/j.cell.2016.04.010	journal	May 2016
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires Tian, Ming; Cheng, Cheng; Chen, Xuejun Cell, Vol. 166, Issue 6 https://doi.org/10.1016/j.cell.2016.07.029	journal	September 2016
Cloning and expression of murine Ig genes from single B cells Tiller, Thomas; Busse, Christian E.; Wardemann, Hedda Journal of Immunological Methods, Vol. 350, Issue 1-2 https://doi.org/10.1016/j.jim.2009.08.009	journal	October 2009
Conservation, Compensation, and Evolution of N-Linked Glycans in the HIV-1 Group M Subtypes and Circulating Recombinant Forms Travers, Simon A. ISRN AIDS, Vol. 2012 https://doi.org/10.5402/2012/823605	journal	January 2012
Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan Umotoy, Jeffrey; Bagaya, Bernard S.; Joyce, Collin Immunity, Vol. 51, Issue 1 https://doi.org/10.1016/j.immuni.2019.06.004	journal	July 2019
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 West, Anthony P.; Diskin, Ron; Nussenzweig, Michel C. Proceedings of the National Academy of Sciences, Vol. 109, Issue 30 https://doi.org/10.1073/pnas.1208984109	journal	June 2012
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site Wu, X.; Wang, C.; O'Dell, S. Journal of Virology, Vol. 86, Issue 10 https://doi.org/10.1128/JVI.07139-11	journal	March 2012
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1 Wu, X.; Yang, Z. -Y.; Li, Y. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1187659	journal	July 2010
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection Wu, Xueling; Zhang, Zhenhai; Schramm, Chaim A. Cell, Vol. 161, Issue 3 https://doi.org/10.1016/j.cell.2015.03.004	journal	April 2015
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing Wu, X.; Zhou, T.; Zhu, J. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207532	journal	August 2011
Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors Yacoob, Christina; Pancera, Marie; Vigdorovich, Vladimir Cell Reports, Vol. 17, Issue 6 https://doi.org/10.1016/j.celrep.2016.10.017	journal	November 2016
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01 Zhou, T.; Georgiev, I.; Wu, X. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1192819	journal	July 2010
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors Zhou, Tongqing; Lynch, Rebecca M.; Chen, Lei Cell, Vol. 161, Issue 6 https://doi.org/10.1016/j.cell.2015.05.007	journal	June 2015
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies Zhou, Tongqing; Zhu, Jiang; Wu, Xueling Immunity, Vol. 39, Issue 2 https://doi.org/10.1016/j.immuni.2013.04.012	journal	August 2013

Similar Records

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Journal Article · 2015 · Cell · OSTI ID:1392136

Wu, Xueling; Zhang, Zhenhai; Schramm, Chaim A.; +50 more

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

Journal Article · 2013 · Immunity · OSTI ID:1258686

Zhou, Tongqing; Zhu, Jiang; Wu, Xueling; +31 more

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-n

Citation Formats

References (50)

Similar Records

Related Subjects