A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- DOE - Office Of Science; National Institutes of Health (NIH)
- OSTI ID:
- 1845493
- Journal Information:
- J. Med. Chem., Vol. 65, Issue (3)
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
The basic science goal in this project identifies structure/affinity relationships for selected radionuclides and existing sorbents. The task will apply this knowledge to the design and synthesis of new sorbents that will exhibit increased cesium, strontium and actinide removal. The target problem focuses on the treatment of high-level nuclear wastes. The general approach can likewise be applied to non-radioactive separations.
Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Synthesis and resolution of (+-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro- 1H-3- benzazepine (TISCH): A high affinity and selective iodinated ligand for CNS D1 dopamine receptor
Technical Report
·
2003
·
OSTI ID:834988
Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
Journal Article
·
2017
· Journal of Medicinal Chemistry
·
OSTI ID:1405018
+38 more
Synthesis and resolution of (+-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro- 1H-3- benzazepine (TISCH): A high affinity and selective iodinated ligand for CNS D1 dopamine receptor
Journal Article
·
1991
· Journal of Medicinal Chemistry; (USA)
·
OSTI ID:5944009
+1 more