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EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies

Journal Article · · MABS-Austin
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1845467
Journal Information:
MABS-Austin, Vol. 10, Issue (8)
Country of Publication:
United States
Language:
ENGLISH

References (34)

The making of bispecific antibodies December 2016
Alternative molecular formats and therapeutic applications for bispecific antibodies October 2015
Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments July 1985
Hybrid hybridomas and their use in immunohistochemistry October 1983
Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library July 1997
Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG April 2010
Improving biophysical properties of a bispecific antibody scaffold to aid developability: Quality by molecular design September 2013
Fab-based bispecific antibody formats with robust biophysical properties and biological activity March 2015
Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells December 2016
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface January 2014
A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism January 2015
Single-chain antigen-binding proteins October 1988
Expression of chimeric receptor composed of immunoglobulin-derived V resions and T-cell receptor-derived C regions December 1987
T Cell Receptor-Extracellular Constant Regions as Hetero-Cross-Linkers for Immunoglobulin Variable Regions June 1993
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies June 2011
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI April 2011
Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties October 2013
The crystal structure of IgE Fc reveals an asymmetrically bent conformation June 2002
Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View August 2013
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity May 2011
Biophysical properties of the clinical-stage antibody landscape January 2017
Antibody Elbow Angles are Influenced by their Light Chain Class April 2006
The Integrity of the Ball-and-Socket Joint Between V and C Domains Is Essential for Complete Activity of a Humanized Antibody February 2001
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding January 2017
Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity January 2015
Domain Interactions in the Fab Fragment: A Comparative Evaluation of the Single-chain Fv and Fab Format Engineered with Variable Domains of Different Stability April 2005
Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment April 2011
Comparing domain interactions within antibody Fabs with kappa and lambda light chains July 2016
[20] Processing of X-ray diffraction data collected in oscillation mode January 1997
MOLREP an Automated Program for Molecular Replacement December 1997
Coot model-building tools for molecular graphics November 2004
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use November 2004
Use of TLS parameters to model anisotropic displacements in macromolecular refinement January 2001
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010

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