High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia

Romero, Larizbeth A.; Hattori, Takamitsu; Ali, Mohamed A.E.; Ketavarapu, Gayatri; Koide, Akiko; Park, Christopher Y.; Koide, Shohei

doi:10.1016/j.jmb.2021.167402

High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia

Journal Article · 28 February 2022 · J. Mol. Biol.

DOI:https://doi.org/10.1016/j.jmb.2021.167402· OSTI ID:1844736

Romero, Larizbeth A.; Hattori, Takamitsu; Ali, Mohamed A.E.; Ketavarapu, Gayatri; Koide, Akiko; Park, Christopher Y.; Koide, Shohei

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; NIH

OSTI ID:: 1844736

Journal Information:: J. Mol. Biol., Journal Name: J. Mol. Biol. Journal Issue: (5) Vol. 434

Country of Publication:: United States

Language:: ENGLISH

References (75)

Flavors of protein disorder Vucetic, Slobodan; Brown, Celeste J.; Dunker, A. Keith Proteins: Structure, Function, and Bioinformatics, Vol. 52, Issue 4 https://doi.org/10.1002/prot.10437	journal	August 2003
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia Liu, Yu; Easton, John; Shao, Ying Nature Genetics, Vol. 49, Issue 8 https://doi.org/10.1038/ng.3909	journal	July 2017
High affinity cross-reacting mAb generated by minimal mimicry: Implications for the pathogenesis of anti-nuclear autoantibodies and immunosuppression Rothermel, A. L.; Altieri, D. C. Proceedings of the National Academy of Sciences, Vol. 95, Issue 7 https://doi.org/10.1073/pnas.95.7.3816	journal	March 1998
The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. Gelin, C.; Aubrit, F.; Phalipon, A. The EMBO Journal, Vol. 8, Issue 11 https://doi.org/10.1002/j.1460-2075.1989.tb08485.x	journal	November 1989
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library Feldhaus, Michael J.; Siegel, Robert W.; Opresko, Lee K. Nature Biotechnology, Vol. 21, Issue 2 https://doi.org/10.1038/nbt785	journal	January 2003
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
CD99 is a therapeutic target on disease stem cells in myeloid malignancies Chung, Stephen S.; Eng, William S.; Hu, Wenhuo Science Translational Medicine, Vol. 9, Issue 374 https://doi.org/10.1126/scitranslmed.aaj2025	journal	January 2017
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993) Goldstone, Anthony H.; Richards, Susan M.; Lazarus, Hillard M. Blood, Vol. 111, Issue 4 https://doi.org/10.1182/blood-2007-10-116582	journal	February 2008
A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. Levy, R.; Dilley, J.; Fox, R. I. Proceedings of the National Academy of Sciences, Vol. 76, Issue 12 https://doi.org/10.1073/pnas.76.12.6552	journal	December 1979
Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2 , a novel paralog of human CD99, and identification of evolutionary conserved motifs Suh, Young Ho; Shin, Young Kee; Kook, Myeong-Cherl Gene, Vol. 307 https://doi.org/10.1016/S0378-1119(03)00401-3	journal	March 2003
Characterization and epitope mapping of two monoclonal antibodies against human CD99 Gil, Min Chan; Lee, Mi-Hong; Seo, Jeong-In Experimental & Molecular Medicine, Vol. 34, Issue 6 https://doi.org/10.1038/emm.2002.58	journal	December 2002
Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen Wang, Guanbo; de Jong, Rob N.; van den Bremer, Ewald T. J. Molecular Cell, Vol. 63, Issue 1 https://doi.org/10.1016/j.molcel.2016.05.016	journal	July 2016
The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model García-Peydró, Marina; Fuentes, Patricia; Mosquera, Marta Journal of Clinical Investigation, Vol. 128, Issue 7 https://doi.org/10.1172/JCI92981	journal	May 2018
SWISS-MODEL: homology modelling of protein structures and complexes Waterhouse, Andrew; Bertoni, Martino; Bienert, Stefan Nucleic Acids Research, Vol. 46, Issue W1 https://doi.org/10.1093/nar/gky427	journal	May 2018
Complement Is Activated by IgG Hexamers Assembled at the Cell Surface Diebolder, C. A.; Beurskens, F. J.; de Jong, R. N. Science, Vol. 343, Issue 6176 https://doi.org/10.1126/science.1248943	journal	March 2014
The CD99 signal enhances Fas-mediated apoptosis in the human leukemic cell line, Jurkat Jung, Kyeong Cheon; Kim, Nam Hyun; Park, Weon Seo FEBS Letters, Vol. 554, Issue 3 https://doi.org/10.1016/S0014-5793(03)01224-9	journal	October 2003
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia Palomero, Teresa; Sulis, Maria Luisa; Cortina, Maria Nature Medicine, Vol. 13, Issue 10 https://doi.org/10.1038/nm1636	journal	September 2007
Recombinant antibodies to histone post-translational modifications Hattori, Takamitsu; Taft, Joseph M.; Swist, Kalina M. Nature Methods, Vol. 10, Issue 10 https://doi.org/10.1038/nmeth.2605	journal	August 2013
Production, Characterization, and Functional Analysis of Newly Established CD99 Monoclonal Antibodies MT99/1 and MT99/2 Khunkaewla, Panida; Chiampanichayakul, Sawitree; Yasamut, Umpa Hybridoma, Vol. 26, Issue 4 https://doi.org/10.1089/hyb.2007.0504	journal	August 2007
Phenotypic Analysis of Antigen-Specific T Lymphocytes Altman, John D.; Moss, Paul A. H.; Goulder, Philip J. R. Science, Vol. 274, Issue 5284 https://doi.org/10.1126/science.274.5284.94	journal	October 1996
Rapid and efficient site-specific mutagenesis without phenotypic selection. Kunkel, T. A. Proceedings of the National Academy of Sciences, Vol. 82, Issue 2, p. 488-492 https://doi.org/10.1073/pnas.82.2.488	journal	January 1985
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993) Marks, David I.; Paietta, Elisabeth M.; Moorman, Anthony V. Blood, Vol. 114, Issue 25 https://doi.org/10.1182/blood-2009-08-231217	journal	December 2009
Isolating and engineering human antibodies using yeast surface display Chao, Ginger; Lau, Wai L.; Hackel, Benjamin J. Nature Protocols, Vol. 1, Issue 2 https://doi.org/10.1038/nprot.2006.94	journal	July 2006
MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration Ambros, Inge M.; Ambros, Peter F.; Strehl, Sabine Cancer, Vol. 67, Issue 7 https://doi.org/10.1002/1097-0142(19910401)67:7<1886::AID-CNCR2820670712>3.0.CO;2-U	journal	April 1991
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members Yang, Yanli; Yeh, Sherry H.; Madireddi, Shravan mAbs, Vol. 11, Issue 6 https://doi.org/10.1080/19420862.2019.1625662	journal	June 2019
Investigating CD99 Expression in Leukemia Propagating Cells in Childhood T Cell Acute Lymphoblastic Leukemia Cox, Charlotte V.; Diamanti, Paraskevi; Moppett, John P. PLOS ONE, Vol. 11, Issue 10 https://doi.org/10.1371/journal.pone.0165210	journal	October 2016
NOTCH 1 pathway activating mutations and clonal evolution in pediatric T‐cell acute lymphoblastic leukemia Kimura, Shunsuke; Seki, Masafumi; Yoshida, Kenichi Cancer Science, Vol. 110, Issue 2 https://doi.org/10.1111/cas.13859	journal	December 2018
The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors Zhao, Linlin; Fu, Qingshan; Pan, Liqiang Frontiers in Cell and Developmental Biology, Vol. 8 https://doi.org/10.3389/fcell.2020.569684	journal	October 2020
CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease Dworzak, M. N.; Fröschl, G.; Printz, D. Leukemia, Vol. 18, Issue 4 https://doi.org/10.1038/sj.leu.2403303	journal	February 2004
The influence of polyvalency on the binding properties of antibodies Crothers, Donald M.; Metzger, Henry Immunochemistry, Vol. 9, Issue 3 https://doi.org/10.1016/0019-2791(72)90097-3	journal	March 1972
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia Real, Pedro J.; Tosello, Valeria; Palomero, Teresa Nature Medicine, Vol. 15, Issue 1 https://doi.org/10.1038/nm.1900	journal	December 2008
The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains Kay, Brian K.; Williamson, Michael P.; Sudol, Marius The FASEB Journal, Vol. 14, Issue 2 https://doi.org/10.1096/fasebj.14.2.231	journal	February 2000
The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition Hattori, Takamitsu; Koide, Akiko; Noval, Maria G. Journal of Molecular Biology, Vol. 433, Issue 3 https://doi.org/10.1016/j.jmb.2020.166748	journal	February 2021
New therapeutic strategies for the treatment of acute lymphoblastic leukaemia Pui, Ching-Hon; Jeha, Sima Nature Reviews Drug Discovery, Vol. 6, Issue 2 https://doi.org/10.1038/nrd2240	journal	February 2007
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia Weng, A. P. Science, Vol. 306, Issue 5694 https://doi.org/10.1126/science.1102160	journal	October 2004
Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience Goldberg, John M.; Silverman, Lewis B.; Levy, Donna E. Journal of Clinical Oncology, Vol. 21, Issue 19 https://doi.org/10.1200/JCO.2003.10.116	journal	October 2003
Acute lymphoblastic leukemia: a comprehensive review and 2017 update Terwilliger, T.; Abdul-Hay, M. Blood Cancer Journal, Vol. 7, Issue 6 https://doi.org/10.1038/bcj.2017.53	journal	June 2017
Evolutionarily Conserved Paired Immunoglobulin-like Receptor α (PILRα) Domain Mediates Its Interaction with Diverse Sialylated Ligands Sun, Yonglian; Senger, Kate; Baginski, Tomasz K. Journal of Biological Chemistry, Vol. 287, Issue 19 https://doi.org/10.1074/jbc.M111.286633	journal	May 2012
The essential role of Ca2+ in the activity of bovine pancreatic deoxyribonuclease. Price, Pa Journal of Biological Chemistry, Vol. 250, Issue 6 https://doi.org/10.1016/S0021-9258(19)41672-4	journal	March 1975
Structure, Function, and Therapeutic Use of IgM Antibodies Keyt, Bruce A.; Baliga, Ramesh; Sinclair, Angus M. Antibodies, Vol. 9, Issue 4 https://doi.org/10.3390/antib9040053	journal	October 2020
Substituting dexamethasone for prednisone complicates remission induction in children with acute lymphoblastic leukemia Hurwitz, Craig A.; Silverman, Lewis B.; Schorin, Marshall A. Cancer, Vol. 88, Issue 8 https://doi.org/10.1002/(SICI)1097-0142(20000415)88:8<1964::AID-CNCR27>3.0.CO;2-1	journal	April 2000
CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination Klaus, Tomasz; Bereta, Joanna Frontiers in Immunology, Vol. 9 https://doi.org/10.3389/fimmu.2018.01096	journal	May 2018
Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia Yadav, Babasaheb D.; Samuels, Amy L.; Wells, Julia E. Oncotarget, Vol. 7, Issue 37 https://doi.org/10.18632/oncotarget.11233	journal	August 2016
Mutagenic PCR. Cadwell, R. C.; Joyce, G. F. Genome Research, Vol. 3, Issue 6 https://doi.org/10.1101/gr.3.6.S136	journal	June 1994
Sequence complexity of disordered protein Romero, Pedro; Obradovic, Zoran; Li, Xiaohong Proteins: Structure, Function, and Genetics, Vol. 42, Issue 1 https://doi.org/10.1002/1097-0134(20010101)42:1<38::AID-PROT50>3.0.CO;2-3	journal	January 2000
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801 DeAngelo, Daniel J.; Yu, Daohai; Johnson, Jeffrey L. Blood, Vol. 109, Issue 12 https://doi.org/10.1182/blood-2006-11-056754	journal	June 2007
Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling Pan, Liqiang; Fu, Tian-Min; Zhao, Wenbin Cell, Vol. 176, Issue 6 https://doi.org/10.1016/j.cell.2019.02.001	journal	March 2019
Highly avid magnetic bead capture: An efficient selection method for de novo protein engineering utilizing yeast surface display Ackerman, Margaret; Levary, David; Tobon, Gabriel Biotechnology Progress, Vol. 25, Issue 3 https://doi.org/10.1002/btpr.174	journal	May 2009
Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE) Kundranda, M.; Gracian, A. C.; Zafar, S. F. Annals of Oncology, Vol. 31, Issue 1 https://doi.org/10.1016/j.annonc.2019.09.004	journal	January 2020
A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells Nakayama, Junichi; Ogawa, Yukie; Yoshigae, Yasushi International Immunology, Vol. 18, Issue 1 https://doi.org/10.1093/intimm/dxh353	journal	December 2005
CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway Kasinrerk, Watchara; Tokrasinwit, Niramon; Moonsom, Seangdeun Immunology Letters, Vol. 71, Issue 1 https://doi.org/10.1016/S0165-2478(99)00165-0	journal	January 2000
Crystal contacts as nature's docking solutions Krissinel, Evgeny Journal of Computational Chemistry, Vol. 31, Issue 1 https://doi.org/10.1002/jcc.21303	journal	January 2010
Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains Sha, F.; Gencer, E. B.; Georgeon, S. Proceedings of the National Academy of Sciences, Vol. 110, Issue 37 https://doi.org/10.1073/pnas.1303640110	journal	August 2013
Towards automated crystallographic structure refinement with phenix.refine Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444912001308	journal	March 2012
Primary refractory and relapsed adult acute lymphoblastic leukemia: Characteristics, treatment results, and prognosis with salvage therapy Thomas, Deborah A.; Kantarjian, Hagop; Smith, Terry L. Cancer, Vol. 86, Issue 7 https://doi.org/10.1002/(SICI)1097-0142(19991001)86:7<1216::AID-CNCR17>3.0.CO;2-O	journal	October 1999
Broad Ranges of Affinity and Specificity of Anti-Histone Antibodies Revealed by a Quantitative Peptide Immunoprecipitation Assay Nishikori, Shingo; Hattori, Takamitsu; Fuchs, Stephen M. Journal of Molecular Biology, Vol. 424, Issue 5 https://doi.org/10.1016/j.jmb.2012.09.022	journal	December 2012
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice Lo, Megan; Kim, Hok Seon; Tong, Raymond K. Journal of Biological Chemistry, Vol. 292, Issue 9 https://doi.org/10.1074/jbc.M116.767749	journal	January 2017
PBDX is the XG blood group gene Ellis, Nathan A.; Tippett, Patricia; Petty, Alison Nature Genetics, Vol. 8, Issue 3 https://doi.org/10.1038/ng1194-285	journal	November 1994
CADM1 Controls Actin Cytoskeleton Assembly and Regulates Extracellular Matrix Adhesion in Human Mast Cells Moiseeva, Elena P.; Straatman, Kees R.; Leyland, Mark L. PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0085980	journal	January 2014
Late Recurrence of Childhood T-Cell Acute Lymphoblastic Leukemia Frequently Represents a Second Leukemia Rather Than a Relapse: First Evidence for Genetic Predisposition Szczepański, Tomasz; van der Velden, Vincent H. J.; Waanders, Esmé Journal of Clinical Oncology, Vol. 29, Issue 12 https://doi.org/10.1200/JCO.2010.30.2877	journal	April 2011
A monovalent streptavidin with a single femtomolar biotin binding site Howarth, Mark; Chinnapen, Daniel J-F; Gerrow, Kimberly Nature Methods, Vol. 3, Issue 4 https://doi.org/10.1038/nmeth861	journal	March 2006
Death induction by CD99 ligation in TEL/AML1-positive acute lymphoblastic leukemia and normal B cell precursors Husak, Z.; Printz, D.; Schumich, A. Journal of Leukocyte Biology, Vol. 88, Issue 2 https://doi.org/10.1189/jlb.0210097	journal	May 2010
A multi-Fc-species system for recombinant antibody production Moutel, Sandrine; El Marjou, Ahmed; Vielemeyer, Ole BMC Biotechnology, Vol. 9, Issue 1 https://doi.org/10.1186/1472-6750-9-14	journal	February 2009
CAR T cells targeting CD99 as an approach to eradicate T-cell acute lymphoblastic leukemia without normal blood cells toxicity Shi, Jiangzhou; Zhang, Zijian; Cen, Hong Journal of Hematology & Oncology, Vol. 14, Issue 1 https://doi.org/10.1186/s13045-021-01178-z	journal	October 2021
Cloning an expressed gene shared by the human sex chromosomes. Darling, S. M.; Banting, G. S.; Pym, B. Proceedings of the National Academy of Sciences, Vol. 83, Issue 1 https://doi.org/10.1073/pnas.83.1.135	journal	January 1986
Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study Fielding, Adele K.; Richards, Susan M.; Chopra, Rajesh Blood, Vol. 109, Issue 3 https://doi.org/10.1182/blood-2006-05-018192	journal	October 2006
The biochemical characterization of E2, a T cell surface molecule involved in rosettes Aubrit, Françoise; Gelin, Catherine; Pham, Danièle European Journal of Immunology, Vol. 19, Issue 8 https://doi.org/10.1002/eji.1830190813	journal	August 1989
Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia: Long-term Follow-up of Relapsed Childhood ALL Chessells, Judith M.; Veys, Paul; Kempski, Helena British Journal of Haematology, Vol. 123, Issue 3 https://doi.org/10.1046/j.1365-2141.2003.04584.x	journal	October 2003
Human TRPML1 channel structures in open and closed conformations Schmiege, Philip; Fine, Michael; Blobel, Günter Nature, Vol. 550, Issue 7676 https://doi.org/10.1038/nature24036	journal	October 2017
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction Li, Shawn S. -C. Biochemical Journal, Vol. 390, Issue 3 https://doi.org/10.1042/BJ20050411	journal	September 2005
A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface de Jong, Rob N.; Beurskens, Frank J.; Verploegen, Sandra PLOS Biology, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pbio.1002344	journal	January 2016
CD99 Signals Caspase-Independent T Cell Death Pettersen, Rolf D.; Bernard, Ghislaine; Olafsen, Mette Kløvstad The Journal of Immunology, Vol. 166, Issue 8 https://doi.org/10.4049/jimmunol.166.8.4931	journal	April 2001

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