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Relaxed Substrate Requirements of Sterol 14[alpha]-Demethylase from Naegleria fowleri Are Accompanie

Journal Article · · J. Med. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1844734
Journal Information:
J. Med. Chem., Vol. 64, Issue (23)
Country of Publication:
United States
Language:
ENGLISH

References (41)

Is Naegleria fowleri an Emerging Parasite? January 2020
Fatal Naegleria fowleri Infection Acquired in Minnesota: Possible Expanded Range of a Deadly Thermophilic Organism January 2012
Successful Treatment of an Adolescent With Naegleria fowleri Primary Amebic Meningoencephalitis March 2015
Geographic Range of Recreational Water-Associated Primary Amebic Meningoencephalitis, United States, 1978–2018 January 2021
Epidemiology and Clinical Characteristics of Primary Amebic Meningoencephalitis Caused by Naegleria fowleri : A Global Review May 2020
CYP51 as drug targets for fungi and protozoan parasites: past, present and future April 2018
Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoebae Naegleria lovaniensis and Naegleria gruberi April 1987
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri September 2018
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae November 2018
Sterol 14α-Demethylase Structure-Based Design of VNI (( R )- N -(1-(2,4-Dichlorophenyl)-2-(1 H -imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis June 2018
Structural basis for conservation in the CYP51 family January 2011
CYP51 from Trypanosoma cruzi November 2005
Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases October 2020
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51 October 2018
A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis July 2020
Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs August 2015
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition September 2014
The Carbon Monoxide-binding Pigment of Liver Microsomes July 1964
CYP51 from Trypanosoma brucei Is Obtusifoliol-Specific August 2004
Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease : STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY September 2013
Sterol 14α-Demethylase as a Potential Target for Antitrypanosomal Therapy: Enzyme Inhibition and Parasite Cell Growth November 2007
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors October 2019
VNI Cures Acute and Chronic Experimental Chagas Disease January 2013
Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections November 2009
Dynamics of CYP51: implications for function and inhibitor design: DYNAMICS OF CYP51 January 2015
The ins and outs of cytochrome P450s March 2007
Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi June 2010
Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth March 2013
Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition July 2014
Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis March 2017
Design or screening of drugs for the treatment of Chagas disease: what shows the most promise? September 2013
A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors November 2017
BLAST-EXPLORER helps you building datasets for phylogenetic analysis January 2010
Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities February 1998
Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum May 2011
Conformational dynamics and molecular interaction reactions of recombinant cytochrome P450scc (CYP11A1) detected by fluorescence energy transfer September 1999
Effect of Therapeutic Chemical Agents In Vitro and on Experimental Meningoencephalitis Due to Naegleria fowleri November 2008
VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis April 2015
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM March 2011
Overview of the CCP 4 suite and current developments March 2011
Features and development of Coot March 2010