Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhi

Journal Article · · ACS Infect. Dis.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; FOREIGN
OSTI ID:
1844729
Journal Information:
ACS Infect. Dis., Vol. 7, Issue (12)
Country of Publication:
United States
Language:
ENGLISH

References (38)

Prokaryotic origin of cytidylyltransferases and α-ketoacid synthases journal March 2004
Potent Inhibitors of a Shikimate Pathway Enzyme from Mycobacterium tuberculosis : COMBINING MECHANISM- AND MODELING-BASED DESIGN journal March 2011
Synthesis and evaluation of dual site inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase journal September 2011
Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from Escherichia coli journal June 2019
Crystal Structure of the Reaction Complex of 3-Deoxy- d - arabino -heptulosonate-7-phosphate Synthase from Thermotoga maritima Refines the Catalytic Mechanism and Indicates a New Mechanism of Allosteric Regulation journal August 2004
Potent Inhibition of 3-Deoxy- d -arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic journal November 2016
Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy- d - arabino- heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic journal January 2017
Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition journal August 2018
Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime journal November 2018
NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB journal September 2019
Computational Investigation of Bisphosphate Inhibitors of 3-Deoxy-d-manno-octulosonate 8-phosphate Synthase journal June 2019
Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes journal July 2002
Phosphoenol acetylphosphonates: Substrate analogues as inhibitors of phosphoenolpyruvate enzymes journal June 1992
Stereoselective Interactions of Phosphoenolpyruvate Analogues with Phosphoenolpyruvate-utilizing Enzymes journal November 1970
Substrate and reaction intermediate mimics as inhibitors of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase journal January 2009
Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase journal March 2005
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate synthase journal June 2006
Towards the development of novel antibiotics: synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase journal December 1999
Translating slow-binding inhibition kinetics into cellular and in vivo effects journal April 2015
Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time: Efficacy and residence time of A2A receptor agonists journal June 2012
Enzyme Architecture: Self-Assembly of Enzyme and Substrate Pieces of Glycerol-3-Phosphate Dehydrogenase into a Robust Catalyst of Hydride Transfer journal November 2016
A Substrate in Pieces: Allosteric Activation of Glycerol 3-Phosphate Dehydrogenase (NAD + ) by Phosphite Dianion journal April 2008
Ligand efficiency: a useful metric for lead selection journal May 2004
Fragment-based lead discovery: leads by design journal July 2005
The High-Resolution Structure of 3-Deoxy- d - arabino -heptulosonate-7-phosphate Synthase Reveals a Twist in the Plane of Bound Phosphoenolpyruvate , journal March 2003
Sulphamethoxazole-trimethoprim: the first two years. journal July 1971
The structure of sodium β-fluoropyruvate: A gem-Diol journal April 1979
Fluorine Bonding — How Does It Work In Protein−Ligand Interactions? journal September 2009
The hydrogen bond between N—H or O—H and organic fluorine: favourable yes, competitive no journal June 2017
Molecular Characterization of the Aeromonas hydrophila aroA Gene and Potential Use of an Auxotrophic aroA Mutant as a Live Attenuated Vaccine journal May 1998
Amplification of the aroA gene from Escherichia coli results in tolerance to the herbicide glyphosate journal July 1983
Antibacterial drug discovery in the resistance era journal January 2016
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance journal November 2016
AN IMPROVED PREPARATIVE METHOD FOR D -ERYTHROSE 4-PHOSPHATE journal June 1966
Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis journal April 2009
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
PHENIX : building new software for automated crystallographic structure determination journal October 2002
Coot model-building tools for molecular graphics journal November 2004