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Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3;#8242;,2;#8242;-cGAMP as

Journal Article · · Nat. Commun.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NIH
OSTI ID:
1844727
Journal Information:
Nat. Commun., Journal Name: Nat. Commun. Vol. 12
Country of Publication:
United States
Language:
ENGLISH

References (35)

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate journal January 2020
Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence journal April 2012
Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling journal November 2015
Features and development of Coot journal March 2010
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems journal June 2017
Structural mechanism of cytosolic DNA sensing by cGAS journal May 2013
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling journal August 2008
HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity journal February 2020
The Card1 nuclease provides defence during type III CRISPR immunity journal January 2021
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States journal December 2019
ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information journal January 2003
Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense journal July 2020
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals journal February 2019
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway journal December 2012
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling journal April 2014
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING journal May 2013
CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection journal July 2020
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers journal July 2017
Cyclic GMP–AMP signalling protects bacteria against viral infection journal September 2019
CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity journal September 2019
Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6 journal March 2020
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila journal July 2021
Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems journal August 2020
Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae journal June 2018
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity journal February 2020
Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas journal September 2019
Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks journal August 2015
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP journal March 2019
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING journal July 2013
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA journal August 2013
STING cyclic dinucleotide sensing originated in bacteria journal September 2020
DALI and the persistence of protein shape journal November 2019
Two cGAS-like receptors induce antiviral immunity in Drosophila journal July 2021

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