Strong, Low-Barrier Hydrogen Bonds May Be Available to Enzymes
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journal
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January 2014 |
Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates
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November 2006 |
Short Carboxylic Acid–Carboxylate Hydrogen Bonds Can Have Fully Localized Protons
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December 2016 |
Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity
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July 2013 |
Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases
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February 2013 |
An Antibiotic-Resistance Enzyme from a Deep-Sea Bacterium
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January 2010 |
Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases † , ‡
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May 2007 |
Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β-Lactamases
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December 2014 |
Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase
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February 2012 |
The Acylation Mechanism of CTX-M β-Lactamase at 0.88 Å Resolution
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May 2007 |
Ab Initio QM/MM Study of Class A β-Lactamase Acylation: Dual Participation of Glu166 and Lys73 in a Concerted Base Promotion of Ser70
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November 2005 |
Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
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March 2020 |
Molecular analysis of beta-lactamase structure and function
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January 2002 |
Mechanism of turnover of imipenem by the TEM .beta.-lactamase revisited
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July 1995 |
Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate
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October 2016 |
Growing Group of Extended-Spectrum -Lactamases: the CTX-M Enzymes
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December 2003 |
Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M β-Lactamases
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April 2005 |
Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography
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June 2015 |
Atomic Resolution Structures of CTX-M β-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability
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April 2005 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Phaser crystallographic software
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July 2007 |
Phaser.MRage : automated molecular replacement
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October 2013 |
Features and development of Coot
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March 2010 |
An Ultrahigh Resolution Structure of TEM-1 β-Lactamase Suggests a Role for Glu166 as the General Base in Acylation
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May 2002 |
Ultrahigh Resolution Structure of a Class A β-Lactamase: On the Mechanism and Specificity of the Extended-spectrum SHV-2 Enzyme
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April 2003 |
The catalytic efficiency (kcat/Km) of the class A β-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog
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April 2010 |
Re-examining the role of Lys67 in class C β-lactamase catalysis
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January 2009 |
Molecular docking and ligand specificity in fragment-based inhibitor discovery
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March 2009 |
Structure and Dynamics of CTX-M Enzymes Reveal Insights into Substrate Accommodation by Extended-spectrum β-Lactamases
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January 2008 |
Structural Insights into Substrate Recognition and Product Expulsion in CTX-M Enzymes
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July 2010 |
More hydrogen bonds for the (structural) biologist
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September 2001 |
An empirical study of amide–heteroarene π-stacking interactions using reversible inhibitors of a bacterial serine hydrolase
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January 2019 |
Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase
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December 2008 |
Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase
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February 2013 |
Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G
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October 1991 |
Protonation of the beta -lactam nitrogen is the trigger event in the catalytic action of class A beta -lactamases
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March 2000 |
Structural Consequences of the Inhibitor-Resistant Ser130Gly Substitution in TEM β-Lactamase † , ‡
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July 2005 |
Low-barrier hydrogen bonds and enzymic catalysis
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June 1994 |
A Low-Barrier Hydrogen Bond in Subtilisin: 1 H and 15 N NMR Studies with Peptidyl Trifluoromethyl Ketones
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January 1996 |
A low-barrier hydrogen bond in the catalytic triad of serine proteases
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June 1994 |
Quantum Chemical Calculations on Structural Models of the Catalytic Site of Chymotrypsin: Comparison of Calculated Results with Experimental Data from NMR Spectroscopy
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November 2002 |
A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment
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November 1997 |
Short strong hydrogen bonds: can they explain enzymic catalysis?
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March 1996 |
Low-Barrier Hydrogen Bond Hypothesis in the Catalytic Triad Residue of Serine Proteases: Correlation between Structural Rearrangement and Chemical Shifts in the Acylation Process
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April 2006 |
The low barrier hydrogen bond (LBHB) proposal revisited: The case of the Asp ··· His pair in serine proteases
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April 2004 |
Using Unnatural Amino Acids to Probe the Energetics of Oxyanion Hole Hydrogen Bonds in the Ketosteroid Isomerase Active Site
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May 2014 |
The Low Barrier Hydrogen Bond in the Photoactive Yellow Protein: A Vacuum Artifact Absent in the Crystal and Solution
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journal
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December 2016 |
Energetics of short hydrogen bonds in photoactive yellow protein
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journal
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December 2011 |
Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)
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journal
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April 2017 |
Determination of Hydrogen Bond Structure in Water versus Aprotic Environments To Test the Relationship Between Length and Stability
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April 2015 |
Structural Bases of Stability–function Tradeoffs in Enzymes
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August 2002 |
Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
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July 2008 |
Evolution of an Antibiotic Resistance Enzyme Constrained by Stability and Activity Trade-offs
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June 2002 |
Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance
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May 2020 |
Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models
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November 2017 |
Modelling proteins’ hidden conformations to predict antibiotic resistance
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October 2016 |