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Structure of the Acinetobacter baumannii PmrA receiver domain and insights into clinical mutants aff

Journal Article · · J. Biochem.
DOI:https://doi.org/10.1093/jb/mvab102· OSTI ID:1844721

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1844721
Journal Information:
J. Biochem., Vol. 170, Issue (6)
Country of Publication:
United States
Language:
ENGLISH

References (80)

Acinetobacter spp. as nosocomial pathogens: Epidemiology and resistance features journal March 2018
The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: a systematic review and meta-analysis journal January 2019
Acinetobacter baumannii: An emerging opportunistic pathogen journal May 2012
The Mechanisms of Disease Caused by Acinetobacter baumannii journal July 2019
An Outbreak of Infections with Acinetobacter calcoaceticus in Burn Patients: Contamination of Patients' Mattresses journal February 1985
Healthcare-associated outbreak due to pan-drug resistant Acinetobacter baumannii in a surgical intensive care unit journal February 2003
The Epidemiology and Control of Acinetobacter baumannii in Health Care Facilities journal March 2006
Desiccation tolerance in Acinetobacter baumannii is mediated by the two-component response regulator BfmR journal October 2018
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges journal January 2017
Risk factors associated with the isolation of colistin-resistant Gram-negative bacteria: A matched case-control study journal January 2008
Successful treatment of septic shock due to pan-resistant Acinetobacter baumannii using combined antimicrobial therapy including tigecycline journal March 2006
Correlation between overexpression and amino acid substitution of the PmrAB locus and colistin resistance in Acinetobacter baumannii journal June 2011
Multidrug resistance among Acinetobacter spp. in the USA and activity profile of key agents: results from CAPITAL Surveillance 2010 journal July 2012
Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019) journal January 2020
Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System journal September 2009
Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production journal December 2010
Emergence of Colistin-Resistance in Extremely Drug-Resistant Acinetobacter baumannii Containing a Novel pmrCAB Operon During Colistin Therapy of Wound Infections journal June 2013
Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens journal May 2016
Transcriptome Remodeling of Acinetobacter baumannii during Infection and Treatment journal May 2017
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates journal August 2019
New Mutations Involved in Colistin Resistance in Acinetobacter baumannii journal April 2020
Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB journal April 2020
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae : a Systematic Review of Current Reports journal December 2020
The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more journal June 2008
Molecular Characterization of the PmrA Regulon journal September 1999
Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment journal March 2016
Two-component signal transduction journal April 2010
To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators: Non-canonical RR activation journal October 2016
The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism journal March 2018
Mechanism of Activation for Transcription Factor PhoB Suggested by Different Modes of Dimerization in the Inactive and Active States journal September 2005
BeFFormula acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeFFormula complex with phosphoserine phosphatase journal July 2001
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix journal October 2019
Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production journal March 2020
Features and development of Coot journal March 2010
Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain journal July 2011
Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA journal November 2015
An asymmetric heterodomain interface stabilizes a response regulator–DNA complex journal February 2014
Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds: Inhibition of response regulator QseB by antibiofilm compounds journal August 2017
Evaluating protein structures determined by structural genomics consortia journal December 2006
Accurate prediction of protein structures and interactions using a three-track neural network journal July 2021
Insights from the revised complete genome sequences of Acinetobacter baumannii strains AB307-0294 and ACICU belonging to global clones 1 and 2 journal October 2019
Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43 journal July 2010
Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae journal December 2013
Program DYNAFIT for the Analysis of Enzyme Kinetic Data: Application to HIV Proteinase journal June 1996
ExPASy: the proteomics server for in-depth protein knowledge and analysis journal July 2003
Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance journal March 2016
Molecular strategies for phosphorylation-mediated regulation of response regulator activity journal April 2010
Millisecond-timescale motions contribute to the function of the bacterial response regulator protein Spo0F journal July 1999
Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp. journal February 2018
Two-component signaling circuit structure and properties journal April 2010
Diglyceride Kinase Mutants of Escherichia coli : Inner Membrane Association of 1,2-Diglyceride and Its Relation to Synthesis of Membrane-Derived Oligosaccharides journal February 1979
The Glycosyltransferases of LPS Core: A Review of Four Heptosyltransferase Enzymes in Context journal October 2017
The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation journal May 2004
A common dimerization interface in bacterial response regulators KdpE and TorR journal December 2005
Structural conservation in the CheY superfamily journal November 1993
Receiver domain structure and function in response regulator proteins journal April 2010
Crystal Structures of the Receiver Domain of the Response Regulator PhoP from Escherichia coli in the Absence and Presence of the Phosphoryl Analog Beryllofluoride journal June 2007
Structural Analysis and Solution Studies of the Activated Regulatory Domain of the Response Regulator ArcA: A Symmetric Dimer Mediated by the α4-β5-α5 Face journal May 2005
A New Perspective on Response Regulator Activation journal November 2006
Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR journal October 2019
Computational Studies of the Active and Inactive Regulatory Domains of Response Regulator PhoP Using Molecular Dynamics Simulations journal June 2017
Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii journal August 2018
The pmrCAB Operon Mediates Polymyxin Resistance in Acinetobacter baumannii ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A journal June 2011
On the role of methionine residues in the sequence-independent recognition of nonpolar protein surfaces journal July 1991
Methionine in proteins: The Cinderella of the proteinogenic amino acids journal August 2019
Two binding modes reveal flexibility in kinase/response regulator interactions in the bacterial chemotaxis pathway journal June 1998
Co-Evolving Motions at Protein−Protein Interfaces of Two-Component Signaling Systems Identified by Covariance Analysis journal June 2008
Characterization of Interactions between a Two-Component Response Regulator, Spo0F, and Its Phosphatase, RapB journal November 1998
Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition journal March 2007
Molecular recognition in signal transduction: the interaction surfaces of the Spo0F response regulator with its cognate phosphorelay proteins revealed by alanine scanning mutagenesis journal September 1997
Identification of communication networks in Spo0F: a model for phosphorylation-induced conformational change and implications for activation of multiple domain bacterial response regulators journal March 1998
Alanine mutants of the Spo0F response regulator modifying specificity for sensor kinases in sporulation initiation journal July 1999
The structure of a transcription activation subcomplex reveals how σ 70 is recruited to PhoB promoters : Structure of a transcription activation subcomplex journal August 2011
Generation and analysis of proline mutants in protein G journal March 2006
Side chain flexibility and the symmetry of protein homodimers journal July 2020
A Conformational Flexibility Scale for Amino Acids in Peptides journal May 2003
Conformational energies and configurational statistics of copolypeptides containing l-proline journal May 1968
Three-dimensional crystal structure of the transcription factor PhoB receiver domain 1 1Edited by R. Huber journal January 1999
Structural insights into the signal transduction mechanism of the K + -sensing two-component system KdpDE journal August 2020