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Title: Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

Journal Article · · Structure

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1844717
Journal Information:
Structure, Vol. 30, Issue (2)
Country of Publication:
United States
Language:
ENGLISH

References (50)

Towards automated crystallographic structure refinement with phenix.refine journal March 2012
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules journal May 2016
Evolution of cysteine patterns in the large extracellular loop of tetraspanins from animals, fungi, plants and single-celled eukaryotes journal July 2010
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals journal October 2012
Coot model-building tools for molecular graphics journal November 2004
TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life journal December 2019
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts journal October 2002
Tetraspanin functions and associated microdomains journal October 2005
Tetraspanin proteins promote multiple cancer stages journal December 2013
Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma journal November 2019
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization journal December 2015
XDS journal January 2010
ADAM-10-Mediated N-Cadherin Cleavage Is Protein Kinase C-  Dependent and Promotes Glioblastoma Cell Migration journal April 2009
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex journal September 2020
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons journal July 2010
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function journal January 2016
The tetraspanin web modulates immune-signalling complexes journal February 2005
CD81-Dependent Trafficking of CD19: Restoration of CD19 Surface Expression in Human B Cells Harboring A CD81 Mutation journal November 2012
TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling journal July 2009
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation journal June 2005
Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology? journal September 2005
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins journal June 2017
Collaboration gets the most out of software journal September 2013
Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane. journal March 1993
TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS journal December 2015
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F journal September 2020
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10 journal March 2012
The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer journal April 2009
Genome engineering using the CRISPR-Cas9 system journal October 2013
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins journal July 2017
Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System journal April 2018
New insights into the tetraspanin Tspan5 using novel monoclonal antibodies journal April 2017
Domain integration of ADAM family proteins: Emerging themes from structural studies journal July 2019
Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10 journal December 2017
In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15 journal March 2018
A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity journal November 2018
Biophysics of Notch Signaling journal May 2021
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking journal April 2020
Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81 journal January 2021
Tetraspanin CD151 and integrin α3β1 contribute to the stabilization of integrin α6β4-containing cell-matrix adhesions journal January 2019
Tetraspanins Function as Regulators of Cellular Signaling journal April 2017
Structural insights into tetraspanin CD9 function journal March 2020
Tetraspanins in the humoral immune response journal March 2011
SWISS-MODEL: homology modelling of protein structures and complexes journal May 2018
The tetraspanin CD151 regulates cell morphology and intracellular signaling on laminin-511: Role of CD151 in cell morphology and signaling journal June 2008
Open conformation of tetraspanins shapes interaction partner networks on cell membranes journal August 2020
ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p journal March 2020
Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherins journal February 2001
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling journal April 2018
Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket journal November 2016