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August 2016 |
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Covalent inhibitors design and discovery
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September 2017 |
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An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
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February 2016 |
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Isocyanide 2.0
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January 2020 |
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Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals
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December 2020 |
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Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease
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September 2020 |
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Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
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June 2020 |
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Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
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January 2021 |
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Studies on transformation of Escherichia coli with plasmids
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June 1983 |
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Liquid-Phase Combinatorial Synthesis of Alicyclic β -Lactams via Ugi Four-Component Reaction
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May 2002 |
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Production of Authentic SARS-CoV Mpro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction
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February 2007 |
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Temporal estimates of case-fatality rate for COVID-19 outbreaks in Canada and the United States
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May 2020 |
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Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
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August 2008 |
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Estimating COVID-19 mortality in Italy early in the COVID-19 pandemic
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May 2021 |
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Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities
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November 2020 |
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Direct incorporation of experimental phase information in model refinement
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November 2004 |
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Phaser crystallographic software
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July 2007 |
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P 1 Lactam Moieties as l -Glutamine Replacements
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April 1999 |
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An electrophilic warhead library for mapping the reactivity and accessibility of tractable cysteines in protein kinases
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December 2020 |
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COVALENT DRUGS FORM LONG-LIVED TIES: IRREVERSIBLE INHIBITORS may provide unique benefits in drug development
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September 2011 |
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Thermal and high pressure intramolecular Diels–Alder reaction of vinylsulfonamides
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December 2006 |
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Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations
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February 2021 |
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Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors
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April 2021 |
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SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study
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September 2020 |
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Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
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June 2005 |
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Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
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January 2013 |
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Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
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October 2021 |
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Validation and extraction of molecular-geometry information from small-molecule databases
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February 2017 |
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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
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March 2020 |
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Six months of COVID vaccines: what 1.7 billion doses have taught scientists
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June 2021 |
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Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
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July 2021 |
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3-Oxo-hexahydro-1 H -isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors
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December 2015 |
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Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase
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October 2008 |
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A review of studies on animal reservoirs of the SARS coronavirus
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April 2008 |
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Viral targets for vaccines against COVID-19
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December 2020 |
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Coot model-building tools for molecular graphics
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November 2004 |
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
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February 2020 |
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Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry
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March 2018 |
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An efficient, catalyst- and solvent-free N -formylation of aromatic and aliphatic amines
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June 2011 |
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Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs
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June 2003 |
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Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening
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September 2020 |
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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
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November 2013 |
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Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
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August 2020 |
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Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases
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March 2020 |
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Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction
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January 2004 |
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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
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March 2021 |
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Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
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February 2021 |
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Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique1
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January 2005 |
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Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
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April 2020 |
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The Effectiveness of the Two-Dose BNT162b2 Vaccine: Analysis of Real-World Data
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May 2021 |
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Discovery of covalent prolyl oligopeptidase boronic ester inhibitors
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January 2020 |
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α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
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February 2020 |
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CCP 4 i 2: the new graphical user interface to the CCP 4 program suite
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February 2018 |
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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
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July 2020 |
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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
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October 2020 |