Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attac

Wensel, David; Williams, Shawn; Dixon, David P.; Ward, Paris; McCormick, Patti; Concha, Nestor; Stewart, Eugene; Hong, Xuan; Mazzucco, Charles; Pal, Shreya; Ding, Bo; Fellinger, Christoph; Krystal, Mark

doi:10.1016/j.jmb.2021.167395

Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attac

Journal Article · 01 January 2022 · J. Mol. Biol.

DOI:https://doi.org/10.1016/j.jmb.2021.167395· OSTI ID:1844619

Wensel, David; Williams, Shawn; Dixon, David P.; Ward, Paris; McCormick, Patti; Concha, Nestor; Stewart, Eugene; Hong, Xuan; Mazzucco, Charles; Pal, Shreya; Ding, Bo; Fellinger, Christoph; Krystal, Mark

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1844619

Journal Information:: J. Mol. Biol., Vol. 434, Issue (2)

Country of Publication:: United States

Language:: ENGLISH

References (75)

Long-Term Quality-of-Life Outcomes Among Adults Living with HIV in the HAART Era: The Interplay of Changes in Clinical Factors and Symptom Profile Burgoyne, Robert W.; Rourke, Sean B.; Behrens, Dean M. AIDS and Behavior, Vol. 8, Issue 2 https://doi.org/10.1023/B:AIBE.0000030246.19577.fb	journal	June 2004
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection Palella, Frank J.; Delaney, Kathleen M.; Moorman, Anne C. New England Journal of Medicine, Vol. 338, Issue 13 https://doi.org/10.1056/NEJM199803263381301	journal	March 1998
Modest Nonadherence to Antiretroviral Therapy Promotes Residual HIV-1 Replication in the Absence of Virological Rebound in Plasma Pasternak, Alexander O.; de Bruin, Marijn; Jurriaans, Suzanne The Journal of Infectious Diseases, Vol. 206, Issue 9 https://doi.org/10.1093/infdis/jis502	journal	August 2012
HIV drug resistance: problems and perspectives Pennings, Pleuni S. Infectious Disease Reports, Vol. 5, Issue 1S https://doi.org/10.4081/idr.2013.s1.e5	journal	June 2013
Adverse effects of chronic treatment with the Main subclasses of highly active antiretroviral therapy: a systematic review Silva, Bf; Peixoto, Gml; Luz, Sr HIV Medicine, Vol. 20, Issue 7 https://doi.org/10.1111/hiv.12733	journal	April 2019
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family Maddon, P.; Littman, D.; Godfrey, M. Cell, Vol. 42, Issue 1 https://doi.org/10.1016/S0092-8674(85)80105-7	journal	August 1985
Interaction between CD4 and class II MHC molecules mediates cell adhesion Doyle, Carolyn; Strominger, Jack L. Nature, Vol. 330, Issue 6145 https://doi.org/10.1038/330256a0	journal	November 1987
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule Wang, J. -h.; Meijers, R.; Xiong, Y. Proceedings of the National Academy of Sciences, Vol. 98, Issue 19 https://doi.org/10.1073/pnas.191124098	journal	September 2001
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus Dalgleish, Angus G.; Beverley, Peter C. L.; Clapham, Paul R. Nature, Vol. 312, Issue 5996 https://doi.org/10.1038/312763a0	journal	December 1984
HIV: Cell Binding and Entry Wilen, C. B.; Tilton, J. C.; Doms, R. W. Cold Spring Harbor Perspectives in Medicine, Vol. 2, Issue 8 https://doi.org/10.1101/cshperspect.a006866	journal	April 2012
Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule McDougal, J. S.; Kennedy, M. S.; Sligh, J. M. Science, Vol. 231, Issue 4736 https://doi.org/10.1126/science.3001934	journal	January 1986
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Kwong, Peter D.; Wyatt, Richard; Robinson, James Nature, Vol. 393, Issue 6686 https://doi.org/10.1038/31405	journal	June 1998
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption Scheid, Johannes F.; Horwitz, Joshua A.; Bar-On, Yotam Nature, Vol. 535, Issue 7613 https://doi.org/10.1038/nature18929	journal	June 2016
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Caskey, Marina; Klein, Florian; Lorenzi, Julio C. C. Nature, Vol. 522, Issue 7557 https://doi.org/10.1038/nature14411	journal	April 2015
Combination therapy with anti-HIV-1 antibodies maintains viral suppression Mendoza, Pilar; Gruell, Henning; Nogueira, Lilian Nature, Vol. 561, Issue 7724 https://doi.org/10.1038/s41586-018-0531-2	journal	September 2018
Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults: VRC01 HIV-1 mAb in healthy adults Ledgerwood, J. E.; Coates, E. E.; Yamshchikov, G. Clinical & Experimental Immunology, Vol. 182, Issue 3 https://doi.org/10.1111/cei.12692	journal	September 2015
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection Lynch, Rebecca M.; Boritz, Eli; Coates, Emily E. Science Translational Medicine, Vol. 7, Issue 319 https://doi.org/10.1126/scitranslmed.aad5752	journal	December 2015
Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial Mayer, Kenneth H.; Seaton, Kelly E.; Huang, Yunda PLOS Medicine, Vol. 14, Issue 11 https://doi.org/10.1371/journal.pmed.1002435	journal	November 2017
Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial Crowell, Trevor A.; Colby, Donn J.; Pinyakorn, Suteeraporn The Lancet HIV, Vol. 6, Issue 5 https://doi.org/10.1016/S2352-3018(19)30053-0	journal	May 2019
Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing Human Immunodeficiency Virus (HIV)-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants Cunningham, Coleen K.; McFarland, Elizabeth J.; Morrison, R. Leavitt The Journal of Infectious Diseases, Vol. 222, Issue 4 https://doi.org/10.1093/infdis/jiz532	journal	November 2019
Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial Gaudinski, Martin R.; Houser, Katherine V.; Doria-Rose, Nicole A. The Lancet HIV, Vol. 6, Issue 10 https://doi.org/10.1016/S2352-3018(19)30181-X	journal	October 2019
Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir Wang, Tao; Ueda, Yasu; Zhang, Zhongxing Journal of Medicinal Chemistry, Vol. 61, Issue 14 https://doi.org/10.1021/acs.jmedchem.8b00759	journal	June 2018
Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection Kozal, Michael; Aberg, Judith; Pialoux, Gilles New England Journal of Medicine, Vol. 382, Issue 13 https://doi.org/10.1056/NEJMoa1902493	journal	March 2020
Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced individuals: week 96 results of the phase 3 BRIGHTE study Lataillade, Max; Lalezari, Jacob P.; Kozal, Michael The Lancet HIV, Vol. 7, Issue 11 https://doi.org/10.1016/S2352-3018(20)30240-X	journal	November 2020
Fostemsavir: First Approval Markham, Anthony Drugs, Vol. 80, Issue 14 https://doi.org/10.1007/s40265-020-01386-w	journal	August 2020
Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1 Emu, Brinda; Fessel, Jeffrey; Schrader, Shannon New England Journal of Medicine, Vol. 379, Issue 7 https://doi.org/10.1056/NEJMoa1711460	journal	August 2018
A Humanized Form of a CD4-Specific Monoclonal Antibody Exhibits Decreased Antigenicity and Prolonged Plasma Half-Life in Rhesus Monkeys While Retaining Its Unique Biological and Antiviral Properties Reimann, Keith A.; Lin, Wenyu; Bixler, Sarah AIDS Research and Human Retroviruses, Vol. 13, Issue 11 https://doi.org/10.1089/aid.1997.13.933	journal	July 1997
Crystal Structure of HIV-1 Primary Receptor CD4 in Complex with a Potent Antiviral Antibody Freeman, Michael M.; Seaman, Michael S.; Rits-Volloch, Sophia Structure, Vol. 18, Issue 12 https://doi.org/10.1016/j.str.2010.09.017	journal	December 2010
Safety, Pharmacokinetics, and Antiretroviral Activity of Multiple Doses of Ibalizumab (formerly TNX-355), an Anti-CD4 Monoclonal Antibody, in Human Immunodeficiency Virus Type 1-Infected Adults Jacobson, Jeffrey M.; Kuritzkes, Daniel R.; Godofsky, Eliot Antimicrobial Agents and Chemotherapy, Vol. 53, Issue 2 https://doi.org/10.1128/AAC.00942-08	journal	February 2009
A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells Moore, J. P.; Sattentau, Q. J.; Klasse, P. J. Journal of Virology, Vol. 66, Issue 8 https://doi.org/10.1128/jvi.66.8.4784-4793.1992	journal	August 1992
Epitope Mapping of Ibalizumab, a Humanized Anti-CD4 Monoclonal Antibody with Anti-HIV-1 Activity in Infected Patients Song, Ruijiang; Franco, David; Kao, Chia-Ying Journal of Virology, Vol. 84, Issue 14 https://doi.org/10.1128/JVI.00453-10	journal	July 2010
Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab Toma, J.; Weinheimer, S. P.; Stawiski, E. Journal of Virology, Vol. 85, Issue 8 https://doi.org/10.1128/JVI.02237-10	journal	February 2011
Adnectins: engineered target-binding protein therapeutics Lipovsek, D. Protein Engineering Design and Selection, Vol. 24, Issue 1-2 https://doi.org/10.1093/protein/gzq097	journal	November 2010
Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint Ramamurthy, Vidhyashankar; Krystek, Stanley R.; Bush, Alexander Structure, Vol. 20, Issue 2 https://doi.org/10.1016/j.str.2011.11.016	journal	February 2012
The fibronectin type III domain as a scaffold for novel binding proteins Koide, Akiko; Bailey, Charles W.; Huang, Xiaolin Journal of Molecular Biology, Vol. 284, Issue 4 https://doi.org/10.1006/jmbi.1998.2238	journal	December 1998
Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity Wensel, David; Sun, Yongnian; Li, Zhufang Antimicrobial Agents and Chemotherapy, Vol. 61, Issue 8 https://doi.org/10.1128/AAC.00508-17	journal	August 2017
Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review Percy, Andrew J.; Rey, Martial; Burns, Kyle M. Analytica Chimica Acta, Vol. 721 https://doi.org/10.1016/j.aca.2012.01.037	journal	April 2012
Dimeric association and segmental variability in the structure of human CD4 Wu, Hao; Kwong, Peter D.; Hendrickson, Wayne A. Nature, Vol. 387, Issue 6632 https://doi.org/10.1038/387527a0	journal	May 1997
The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. Moebius, U.; Clayton, L. K.; Abraham, S. Journal of Experimental Medicine, Vol. 176, Issue 2 https://doi.org/10.1084/jem.176.2.507	journal	August 1992
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies Sanders, Rogier W.; Derking, Ronald; Cupo, Albert PLoS Pathogens, Vol. 9, Issue 9, Article No. e1003618 https://doi.org/10.1371/journal.ppat.1003618	journal	September 2013
GSK3732394: a Multi-specific Inhibitor of HIV Entry Wensel, David; Sun, Yongnian; Davis, Jonathan Journal of Virology, Vol. 93, Issue 20 https://doi.org/10.1128/JVI.00907-19	journal	October 2019
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike Ozorowski, Gabriel; Pallesen, Jesper; de Val, Natalia Nature, Vol. 547, Issue 7663 https://doi.org/10.1038/nature23010	journal	July 2017
Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer Yadav, Suresh Singh; Prasad, Shyam Babu; Das, Mitali BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/581403	journal	January 2014
CD40-Mediated Induction of CD4 and CXCR4 on B Lymphocytes Correlates with Restricted Susceptibility to Human Immunodeficiency Virus Type 1 Infection: Potential Role of B Lymphocytes as a Viral Reservoir Moir, Susan; Lapointe, Réjean; Malaspina, Angela Journal of Virology, Vol. 73, Issue 10 https://doi.org/10.1128/JVI.73.10.7972-7980.1999	journal	October 1999
A Synthetic Peptide from HIV-1 gp41 Is a Potent Inhibitor of Virus-Mediated Cell—Cell Fusion Wild, Carl; Greenwell, Teresa; Matthews, Thomas AIDS Research and Human Retroviruses, Vol. 9, Issue 11 https://doi.org/10.1089/aid.1993.9.1051	journal	November 1993
The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex: A Phase 1 Study Kahn, James O. Annals of Internal Medicine, Vol. 112, Issue 4 https://doi.org/10.7326/0003-4819-112-4-	journal	February 1990
Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex: A Phase I-II Escalating Dosage Trial Schooley, Robert T. Annals of Internal Medicine, Vol. 112, Issue 4 https://doi.org/10.7326/0003-4819-112-4-247	journal	February 1990
Combination Therapy with Recombinant Human Soluble CD4-Immunoglobulin G and Zidovudine in Patients with HIV Infection: A Phase I Study Meng, Tze-Chiang; Fischl, Margaret A.; Cheeseman, Sarah H. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, Vol. 8, Issue 2 https://doi.org/10.1097/00042560-199502000-00006	journal	January 1995
Nonlinear pharmacokinetics of high-dose recombinant fusion protein CD4-IgG2 (PRO 542) observed in HIV-1–infected children Fletcher, Courtney V.; DeVille, Jaime G.; Samson, Pearl M. Journal of Allergy and Clinical Immunology, Vol. 119, Issue 3 https://doi.org/10.1016/j.jaci.2006.10.045	journal	March 2007
Treatment of Advanced Human Immunodeficiency Virus Type 1 Disease with the Viral Entry Inhibitor PRO 542 Jacobson, Jeffrey M.; Israel, Robert J.; Lowy, Israel Antimicrobial Agents and Chemotherapy, Vol. 48, Issue 2 https://doi.org/10.1128/AAC.48.2.423-429.2004	journal	February 2004
Single‐Dose Safety, Pharmacology, and Antiviral Activity of the Human Immunodeficiency Virus (HIV) Type 1 Entry Inhibitor PRO 542 in HIV‐Infected Adults Jacobson, Jeffrey M.; Lowy, Israel; Fletcher, Courtney V. The Journal of Infectious Diseases, Vol. 182, Issue 1 https://doi.org/10.1086/315698	journal	July 2000
Fostemsavir: The first oral attachment inhibitor for treatment of HIV-1 infection Chahine, Elias B. American Journal of Health-System Pharmacy, Vol. 78, Issue 5 https://doi.org/10.1093/ajhp/zxaa416	journal	February 2021
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding Scheid, J. F.; Mouquet, H.; Ueberheide, B. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207227	journal	July 2011
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01 Zhou, T.; Georgiev, I.; Wu, X. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1192819	journal	July 2010
Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo Rudicell, R. S.; Kwon, Y. D.; Ko, S. -Y. Journal of Virology, Vol. 88, Issue 21 https://doi.org/10.1128/JVI.02213-14	journal	August 2014
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth Huang, Jinghe; Kang, Byong H.; Ishida, Elise Immunity, Vol. 45, Issue 5 https://doi.org/10.1016/j.immuni.2016.10.027	journal	November 2016
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang Cell, Vol. 165, Issue 2 https://doi.org/10.1016/j.cell.2016.02.022	journal	April 2016
Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody Schommers, Philipp; Gruell, Henning; Abernathy, Morgan E. Cell, Vol. 180, Issue 3 https://doi.org/10.1016/j.cell.2020.01.010	journal	February 2020
Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition Corey, Lawrence; Gilbert, Peter B.; Juraska, Michal New England Journal of Medicine, Vol. 384, Issue 11 https://doi.org/10.1056/NEJMoa2031738	journal	March 2021
Structural and Biophysical Insights into the Role of CD4 and CD8 in T Cell Activation Li, Yili; Yin, Yiyuan; Mariuzza, Roy A. Frontiers in Immunology, Vol. 4 https://doi.org/10.3389/fimmu.2013.00206	journal	January 2013
Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex Wang, C. Y.; Sawyer, L. S. W.; Murthy, K. K. Proceedings of the National Academy of Sciences, Vol. 96, Issue 18 https://doi.org/10.1073/pnas.96.18.10367	journal	August 1999
Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption Wang, Chang-Yi; Wong, Wing-Wai; Tsai, Hung-Chin New England Journal of Medicine, Vol. 380, Issue 16 https://doi.org/10.1056/NEJMoa1802264	journal	April 2019
Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1–neutralizing activity Song, Ruijiang; Oren, Deena A.; Franco, David Nature Biotechnology, Vol. 31, Issue 11 https://doi.org/10.1038/nbt.2677	journal	November 2013
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer Liu, Qingbo; Acharya, Priyamvada; Dolan, Michael A. Nature Structural & Molecular Biology, Vol. 24, Issue 4 https://doi.org/10.1038/nsmb.3382	journal	February 2017
Structural basis of coreceptor recognition by HIV-1 envelope spike Shaik, Md Munan; Peng, Hanqin; Lu, Jianming Nature, Vol. 565, Issue 7739 https://doi.org/10.1038/s41586-018-0804-9	journal	December 2018
Anti-CD4 Monoclonal Antibody Ibalizumab Exhibits Breadth and Potency Against HIV-1, With Natural Resistance Mediated by the Loss of a V5 Glycan in Envelope Pace, Craig S.; Fordyce, Marshall W.; Franco, David JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 62, Issue 1 https://doi.org/10.1097/QAI.0b013e3182732746	journal	January 2013
Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4 Yin, Y.; Wang, X. X.; Mariuzza, R. A. Proceedings of the National Academy of Sciences, Vol. 109, Issue 14 https://doi.org/10.1073/pnas.1118801109	journal	March 2012
Molecular replacement with MOLREP Vagin, Alexei; Teplyakov, Alexei Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042589	journal	December 2009
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
REFMAC 5 for the refinement of macromolecular crystal structures Murshudov, Garib N.; Skubák, Pavol; Lebedev, Andrey A. Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444911001314	journal	March 2011
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix Liebschner, Dorothee; Afonine, Pavel V.; Baker, Matthew L. Acta Crystallographica Section D Structural Biology, Vol. 75, Issue 10 https://doi.org/10.1107/S2059798319011471	journal	October 2019
cisTEM, user-friendly software for single-particle image processing Grant, Timothy; Rohou, Alexis; Grigorieff, Nikolaus eLife, Vol. 7 https://doi.org/10.7554/eLife.35383	journal	March 2018
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs Bepler, Tristan; Morin, Andrew; Rapp, Micah Nature Methods, Vol. 16, Issue 11 https://doi.org/10.1038/s41592-019-0575-8	journal	October 2019
Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy Rosenthal, Peter B.; Henderson, Richard Journal of Molecular Biology, Vol. 333, Issue 4 https://doi.org/10.1016/j.jmb.2003.07.013	journal	October 2003
In Vitro Cross-Resistance Profile of Nucleoside Reverse Transcriptase Inhibitor (NRTI) BMS-986001 against Known NRTI Resistance Mutations Li, Zhufang; Terry, Brian; Olds, William Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 11 https://doi.org/10.1128/AAC.01195-13	journal	November 2013

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