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Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1

Journal Article · · J. Med. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1841233
Journal Information:
J. Med. Chem., Vol. 65, Issue (1)
Country of Publication:
United States
Language:
ENGLISH

References (49)

PPARalpha regulates the production of serum Vanin-1 by liver journal October 2013
Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases journal January 2012
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice journal October 2000
The Linkage Between Coenzyme A Metabolism and Inflammation: Roles of Pantetheinase journal January 2013
Vanin-1 −/− Mice Exhibit a Glutathione-Mediated Tissue Resistance to Oxidative Stress journal August 2004
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity journal December 2006
Vanin-1–/– mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores journal February 2004
Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions journal July 2015
Characterization of intestinal gene expression profiles in Crohnʼs disease by genome-wide microarray analysis journal January 2010
Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations journal November 2012
Functional Polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with Susceptibility to Inflammatory Bowel Diseases journal January 2013
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model journal January 2010
Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease journal January 2007
Vanin 1: Its Physiological Function and Role in Diseases journal August 2019
The art of the chemical probe journal March 2010
Dose Predictions for Drug Design journal January 2020
New Trends in Photobiology (Invited Review) Photosensitizing drugs containing the benzophenone chromophore journal April 1998
Experimental study on phototoxicity and the photosensitization potential of ketoprofen, suprofen, tiaprofenic acid and benzophenone and the photocross-reactivity in guinea pigs journal April 2002
Spectrum of cross-photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen: associated photoallergies to non-benzophenone-containing molecules: Cross-Photosensitization Induced by Ketoprofen journal March 2003
Phototoxic and photoallergic reactions journal July 2009
A fluorescent assay suitable for inhibitor screening and vanin tissue quantification journal April 2010
An ESTs description of the new Vanin gene family conserved from fly to human journal September 1999
Development of a new permeability assay using low‐efflux MDCKII cells journal November 2011
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease journal January 2021
Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis journal September 2017
Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models journal April 2020
Review article: mode of action and delivery of 5-aminosalicylic acid – new evidence journal September 2006
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success journal November 2009
Lipophilic Efficiency as an Important Metric in Drug Design journal March 2018
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability journal May 2016
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors journal December 2017
Addressing the Challenges of Low Clearance in Drug Research journal January 2015
Challenges in IBD Research: Preclinical Human IBD Mechanisms journal May 2019
Accelerating Proof of Concept for Small Molecule Drugs Using Solid-State Chemistry journal September 2010
Optimizing the physical form – opportunities and limitations journal June 2012
State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation journal December 2018
Catalytic Asymmetric Synthesis of tert -Butanesulfinamide. Application to the Asymmetric Synthesis of Amines journal October 1997
Applications of tert-butanesulfinamide in the asymmetric synthesis of amines journal January 2003
Synthesis and Applications of tert -Butanesulfinamide journal June 2010
Synthesis and chiroptical properties of 1-(4-,5-pyrimidyl)ethylamines journal January 1977
A convenient aminolysis of esters catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions journal May 2007
Indigo Naturalis Alleviates Dextran Sulfate Sodium-Induced Colitis in Rats via Altering Gut Microbiota journal April 2020
Engineering novel Lec1 glycosylation mutants in CHO-DUKX cells: Molecular insights and effector modulation of N-acetylglucosaminyltransferase I journal February 2012
XDS journal January 2010
Data processing and analysis with the autoPROC toolbox journal March 2011
Overview of the CCP 4 suite and current developments journal March 2011
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
Features and development of Coot journal March 2010
The Protein Data Bank journal January 2000