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How Tim proteins differentially exploit membrane features to attain robust target sensitivity

Journal Article · · Biophys. J.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; NSF
DOE Contract Number:
NONE;
OSTI ID:
1841215
Journal Information:
Biophys. J., Journal Name: Biophys. J. Journal Issue: (21) Vol. 120
Country of Publication:
United States
Language:
ENGLISH

References (81)

Constitutive neutrophil apoptosis: Mechanisms and regulation journal April 2008
TIM‐3 and CEACAM1 do not interact in cis and in trans journal April 2020
Phospholipase D and immune receptor signalling journal February 2002
Phospholipid composition of cultured human endothelial cells journal February 1992
Phospholipase D: a lipid centric review journal September 2005
Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells journal June 1982
Polyunsaturated fatty acids are enriched in the plasma membranes of mitogen-stimulated T-lymphocytes journal November 1987
Small-volume extrusion apparatus for preparation of large, unilamellar vesicles journal January 1991
Electrostatics and reduction of dimensionality produce apparent cooperativity when basic peptides bind to acidic lipids in membranes journal March 1992
The activation of rat platelets increases the exposure of polyunsaturated fatty acid enriched phospholipids on the external leaflet of the plasma membrane journal July 1993
Phospholipid metabolism of stimulated lymphocytes journal September 1975
Fatty acid metabolism in human lymphocytes. I. Time-course changes in fatty acid composition and membrane fluidity during blastic transformation of peripheral blood lymphocytes journal June 1990
Lipid dynamics and peripheral interactions of proteins with membrane surfaces journal September 1994
Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling journal August 1996
The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid journal November 1997
Molecular Dynamics Simulation of a Palmitoyl-Oleoyl Phosphatidylserine Bilayer with Na+ Counterions and NaCl journal March 2004
Binding of Peripheral Proteins to Mixed Lipid Membranes: Effect of Lipid Demixing upon Binding journal May 1999
A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid. journal December 1993
Respiratory burst in human neutrophils journal December 1999
A novel protein kinase target for the lipid second messenger phosphatidic acid journal July 1999
A novel type of allosteric regulation: Functional cooperativity in monomeric proteins journal March 2012
Phosphatidic acid- and phosphatidylserine-binding proteins journal August 2006
Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine journal February 2014
Molecular details of membrane fluidity changes during apoptosis and relationship to phospholipase A2 activity journal February 2013
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties journal November 2016
Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins journal October 2018
Amphipathic Lipid Packing Sensor Motifs: Probing Bilayer Defects with Hydrophobic Residues journal February 2013
Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1 journal October 2017
Increased pH-sensitivity of protein binding to lipid membranes through the electrostatic-hydrogen bond switch journal April 2013
The interactions of peripheral membrane proteins with biological membranes journal November 2015
Revisiting transbilayer distribution of lipids in the plasma membrane journal January 2016
Hetero-multivalent binding of cholera toxin subunit B with glycolipid mixtures journal December 2017
Molecular dynamics simulation of a phosphatidylglycerol membrane journal December 2005
Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family journal March 2007
T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface journal March 2007
Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds journal December 2007
TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells journal December 2007
The 2.5 Å Structure of CD1c in Complex with a Mycobacterial Lipid Reveals an Open Groove Ideally Suited for Diverse Antigen Presentation journal December 2010
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation journal May 2016
Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein journal December 2014
Signaling functions of phosphatidic acid journal May 2006
A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression journal September 2015
Effect of Phosphatidic Acid on Biomembrane: Experimental and Molecular Dynamics Simulations Study journal July 2015
Phospholipid Scramblase Activation Pathways in Lymphocytes journal June 2001
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion journal October 2014
Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1 journal July 2012
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity journal November 2005
Membrane recognition by phospholipid-binding domains journal February 2008
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape journal May 2020
Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement journal August 1993
Time-course changes in content and fatty acid composition of phosphatidic acid from rat thymocytes during concanavalin A stimulation journal May 1995
Constitutive exposure of phosphatidylserine on viable cells journal November 2011
Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4 journal March 2014
Phospholipid composition of the mammalian red cell membrane can be rationalized by a superlattice model journal April 1998
An Electrostatic/Hydrogen Bond Switch as the Basis for the Specific Interaction of Phosphatidic Acid with Proteins journal February 2007
Entropic and Enthalpic Contributions to Annexin V-Membrane Binding journal March 2008
Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy journal October 2017
Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs journal July 2003
The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis journal May 2014
Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family journal May 2007
Diverse roles of TIM4 in immune activation: implications for alloimmunity journal January 2018
Comparative lipidomics analysis of HIV-1 particles and their producer cell membrane in different cell lines: Lipidomics of HIV-1 particles and producer plasma membranes journal January 2013
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity: TIM genes: a family of PtdSer receptors journal April 2010
Targeting granulocyte apoptosis: mechanisms, models, and therapies: Targeting granulocyte apoptosis journal June 2010
Phospholipase D Signaling Pathways and Phosphatidic Acid as Therapeutic Targets in Cancer journal September 2014
Quantitative Analysis of Protein-Lipid Interactions Using Tryptophan Fluorescence journal November 2009
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8 + T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression journal April 2015
The Distribution and Function of Phosphatidylserine in Cellular Membranes journal April 2010
Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid journal August 2010
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane journal April 2016
Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells journal January 2009
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation journal April 2009
Putting the pH into phosphatidic acid signaling journal December 2011
The role of phosphatidylserine recognition receptors in multiple biological functions journal March 2020
Plasma membrane asymmetry of lipid organization: fluorescence lifetime microscopy and correlation spectroscopy analysis journal December 2019
TIM-3 Does Not Act as a Receptor for Galectin-9 journal March 2013
Membrane Fluidity Is a Key Modulator of Membrane Binding, Insertion, and Activity of 5-Lipoxygenase journal June 2005
Examining the Contributions of Lipid Shape and Headgroup Charge on Bilayer Behavior journal September 2008
TIM-3 Regulates Distinct Functions in Macrophages journal June 2016
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid journal April 2018
T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells journal January 2010

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