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Hydrophobically modified polypeptoids and uses thereof

Patent ·
OSTI ID:1840460
; ; ;

A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery.

Research Organization:
Louisiana State Univ., Baton Rouge, LA (United States); Tulane Univ., New Orleans, LA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0012432
Assignee:
Board of Supervisors of Louisiana State University (Baton Rouge, LA); The Administrators of the Tulane Educational Fund (New Orleans, LA)
Patent Number(s):
11,123,433
Application Number:
16/306,429
OSTI ID:
1840460
Country of Publication:
United States
Language:
English

References (7)

Structure/Function Analysis of Peptoid/Lipitoid:DNA Complexes journal September 2003
Thermoresponsive Poly(α-peptoid)s: Tuning the Cloud Point Temperatures by Composition and Architecture journal April 2012
Drug delivery systems: Advanced technologies potentially applicable in personalized treatments journal March 2010
Synthesis and characterization of thermo-responsive polypeptoid bottlebrushes journal January 2014
Highly Defined Multiblock Copolypeptoids: Pushing the Limits of Living Nucleophilic Ring-Opening Polymerization journal June 2012
Synthesis and Characterization of Cleavable Core-Cross-Linked Micelles Based on Amphiphilic Block Copolypeptoids as Smart Drug Carriers journal February 2016
Crystallization and Melting Behaviors of Cyclic and Linear Polypeptoids with Alkyl Side Chains journal October 2013

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