Human blood molecular biodosimeter panel for distinguishing radiation exposure from inflammation stress

Wyrobek, Andrew J.; Snijders, Antoine M.

Human blood molecular biodosimeter panel for distinguishing radiation exposure from inflammation stress

Patent · 31 August 2021

OSTI ID:1840390

Wyrobek, Andrew J.; Snijders, Antoine M.

Panels of 8-, 9- and 12-biomarker for diagnostic and prognostic methods to determine a subject's radiation exposure and discriminates between persons who have been exposed to radiation only, inflammation stress only, or a combination of the two.

View Patent

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; US Dept. of Health and Human Services (HHS)

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 11,104,950

Application Number:: 14/536,543

OSTI ID:: 1840390

Country of Publication:: United States

Language:: English

References (47)

Gamma-radiation-induced ATM-dependent signalling in human T-lymphocyte leukemic cells, MOLT-4. Tichý, Ales; Záskodová, Darina; Rezácová, Martina Acta Biochimica Polonica, Vol. 54, Issue 2 https://doi.org/10.18388/abp.2007_3248	journal	June 2007
Radiation dose effect of DNA repair-related gene expression in mouse white blood cells Li, Ming-juan; Wang, Wei-wei; Chen, Shi-wei Medical Science Monitor, Vol. 17, Issue 10 https://doi.org/10.12659/MSM.881976	journal	January 2011
Long-term global gene expression patterns in irradiated human lymphocytes Falt, S. Carcinogenesis, Vol. 24, Issue 11 https://doi.org/10.1093/carcin/bgg134	journal	June 2003
Prediction of In Vivo Radiation Dose Status in Radiotherapy Patients using Ex Vivo and In Vivo Gene Expression Signatures Paul, Sunirmal; Barker, Christopher A.; Turner, Helen C. Radiation Research, Vol. 175, Issue 3 https://doi.org/10.1667/RR2420.1	journal	January 2011
γH2AX, pChk1, and Wip1 as Potential Markers of Persistent DNA Damage Derived from Dibenzo[a,l]pyrene and PAH-Containing Extracts from Contaminated Soils Niziolek-Kierecka, Magdalena; Dreij, Kristian; Lundstedt, Staffan Chemical Research in Toxicology, Vol. 25, Issue 4 https://doi.org/10.1021/tx200436n	journal	March 2012
Biodosimetry on Small Blood Volume Using gene Expression Assay Brengues, Muriel; Paap, Brigitte; Bittner, Michael Health Physics, Vol. 98, Issue 2 https://doi.org/10.1097/01.HP.0000346706.44253.5c	journal	January 2010
The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 status Zhang, Ying; Lim, Chang U. K.; Zhou, Junqing Toxicology Letters, Vol. 171, Issue 1-2 https://doi.org/10.1016/j.toxlet.2007.04.006	journal	June 2007
Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein Klungland, Arne; Höss, Matthias; Gunz, Daniela Molecular Cell, Vol. 3, Issue 1 https://doi.org/10.1016/S1097-2765(00)80172-0	journal	January 1999
Candidate protein biodosimeters of human exposure to ionizing radiation Marchetti, Francesco; Coleman, Matthew A.; Jones, Irene M. International Journal of Radiation Biology, Vol. 82, Issue 9 https://doi.org/10.1080/09553000600930103	journal	January 2006
Apoptosis and genomic instability Zhivotovsky, Boris; Kroemer, Guido Nature Reviews Molecular Cell Biology, Vol. 5, Issue 9 https://doi.org/10.1038/nrm1443	journal	September 2004
Induction of decision trees Quinlan, J. R. Machine Learning, Vol. 1, Issue 1, p. 81-106 https://doi.org/10.1007/BF00116251	journal	March 1986
Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase Bessho, T. Nucleic Acids Research, Vol. 27, Issue 4 https://doi.org/10.1093/nar/27.4.979	journal	February 1999
Damage recognition in nucleotide excision repair of DNA Batty, Dawn P.; Wood, Richard D. Gene, Vol. 241, Issue 2 https://doi.org/10.1016/S0378-1119(99)00489-8	journal	January 2000
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals Han, J. -w.; Flemington, C.; Houghton, A. B. Proceedings of the National Academy of Sciences, Vol. 98, Issue 20 https://doi.org/10.1073/pnas.201208798	journal	September 2001
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest Wang, S.; Guo, M.; Ouyang, H. Proceedings of the National Academy of Sciences, Vol. 97, Issue 4 https://doi.org/10.1073/pnas.97.4.1584	journal	February 2000
Current status, new frontiers and challenges in radiation biodosimetry using cytogenetic, transcriptomic and proteomic technologies Fenech, Michael Radiation Measurements, Vol. 46, Issue 9 https://doi.org/10.1016/j.radmeas.2011.01.016	journal	September 2011
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase Shimizu, Y. The EMBO Journal, Vol. 22, Issue 1 https://doi.org/10.1093/emboj/cdg016	journal	January 2003
The RIN: an RNA integrity number for assigning integrity values to RNA measurements Schroeder, Andreas; Mueller, Odilo; Stocker, Susanne BMC Molecular Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2199-7-3	journal	January 2006
Induction of Stress Genes by Low Doses of Gamma Rays Amundson, Sally A.; Do, Khanh T.; Fornace, Albert J. Radiation Research, Vol. 152, Issue 3 https://doi.org/10.2307/3580321	journal	September 1999
LPS induction of gene expression in human monocytes Guha, Mausumee; Mackman, Nigel Cellular Signalling, Vol. 13, Issue 2 https://doi.org/10.1016/S0898-6568(00)00149-2	journal	February 2001
Use of High-Throughput Protein Array for Profiling of Differentially Expressed Proteins in Normal and Malignant Breast Tissue Hudelist, Gernot; Pacher-zavisin, Margit; Singer, Christian Breast Cancer Research and Treatment, Vol. 86, Issue 3 https://doi.org/10.1023/B:BREA.0000036901.16346.83	journal	August 2004
Gene Expression Comparisons Performed for Biodosimetry Purposes on In Vitro Peripheral Blood Cellular Subsets and Irradiated Individuals Riecke, A.; Rufa, C. G.; Cordes, M. Radiation Research, Vol. 178, Issue 3 https://doi.org/10.1667/RR2738.1	journal	September 2012
Gene expression signatures of radiation exposure in peripheral white blood cells of smokers and non-smokers Paul, Sunirmal; Amundson, Sally A. International Journal of Radiation Biology, Vol. 87, Issue 8 https://doi.org/10.3109/09553002.2011.568574	journal	August 2011
Development of Gene Expression Signatures for Practical Radiation Biodosimetry Paul, Sunirmal; Amundson, Sally A. International Journal of Radiation OncologyBiologyPhysics, Vol. 71, Issue 4 https://doi.org/10.1016/j.ijrobp.2008.03.043	journal	July 2008
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Kallioniemi, O. P.; Kallioniemi, A.; Kurisu, W. Proceedings of the National Academy of Sciences, Vol. 89, Issue 12 https://doi.org/10.1073/pnas.89.12.5321	journal	June 1992
Reactions of oxyl radicals with DNA Breen, Anthony P.; Murphy, John A. Free Radical Biology and Medicine, Vol. 18, Issue 6 https://doi.org/10.1016/0891-5849(94)00209-3	journal	June 1995
New functions of XPC in the protection of human skin cells from oxidative damage D'Errico, Mariarosaria; Parlanti, Eleonora; Teson, Massimo The EMBO Journal, Vol. 25, Issue 18 https://doi.org/10.1038/sj.emboj.7601277	journal	September 2006
IL-4 and IL-10 Inhibition of Spontaneous Monocyte Apoptosis Is Associated with Flip Upregulation Eslick, Joy; Scatizzi, John C.; Albee, Lee Inflammation, Vol. 28, Issue 3 https://doi.org/10.1023/B:IFLA.0000039560.00231.cd	journal	June 2004
Gene Expression Signatures of Radiation Response Are Specific, Durable and Accurate in Mice and Humans Meadows, Sarah K.; Dressman, Holly K.; Muramoto, Garrett G. PLoS ONE, Vol. 3, Issue 4 https://doi.org/10.1371/journal.pone.0001912	journal	April 2008
Gene Expression-Based Detection of Radiation Exposure in Mice after Treatment with Granulocyte Colony-Stimulating Factor and Lipopolysaccharide Tucker, James D.; Grever, William E.; Joiner, Michael C. Radiation Research, Vol. 177, Issue 2 https://doi.org/10.1667/RR2749.1	journal	February 2012
Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions Shimizu, Yuichiro; Uchimura, Yasuhiro; Dohmae, Naoshi Journal of Nucleic Acids, Vol. 2010 https://doi.org/10.4061/2010/805698	journal	January 2010
Experimental Design and Analysis of Antibody Microarrays: Applying Methods from cDNA Arrays Eckel-Passow, Jeanette E.; Hoering, Antje; Therneau, Terry M. Cancer Research, Vol. 65, Issue 8 https://doi.org/10.1158/0008-5472.CAN-04-3213	journal	April 2005
Gene Expression Signatures That Predict Radiation Exposure in Mice and Humans Dressman, Holly K.; Muramoto, Garrett G.; Chao, Nelson J. PLoS Medicine, Vol. 4, Issue 4 https://doi.org/10.1371/journal.pmed.0040106	journal	April 2007
Two-phase dynamics of p53 in the DNA damage response Zhang, X. -P.; Liu, F.; Wang, W. Proceedings of the National Academy of Sciences, Vol. 108, Issue 22 https://doi.org/10.1073/pnas.1100600108	journal	May 2011
Gene expression following ionising radiation: Identification of biomarkers for dose estimation and prediction of individual response Kabacik, Sylwia; Mackay, Alan; Tamber, Narinder International Journal of Radiation Biology, Vol. 87, Issue 2 https://doi.org/10.3109/09553002.2010.519424	journal	November 2010
The Cdkn1a gene (p21Waf1/Cip1) is an inflammatory response gene in the mouse central nervous system Ring, Robert H.; Valo, Zuzana; Gao, Chunguang Neuroscience Letters, Vol. 350, Issue 2 https://doi.org/10.1016/S0304-3940(03)00883-8	journal	October 2003
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin? Antoni, Laurent; Sodha, Nayanta; Collins, Ian Nature Reviews Cancer, Vol. 7, Issue 12 https://doi.org/10.1038/nrc2251	journal	December 2007
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2 Hirao, A. Science, Vol. 287, Issue 5459 https://doi.org/10.1126/science.287.5459.1824	journal	March 2000
A Nucleotide Excision Repair Master-Switch: p53 Regulated Coordinate Introduction of Global Genomic Repair Genes Amundson, S. A.; Patterson, A.; Do, K. T. Cancer Biology & Therapy, Vol. 1, Issue 2 https://doi.org/10.4161/cbt.59	journal	March 2002
Human *In vivo* Radiation-Induced Biomarkers: Gene Expression Changes in Radiotherapy Patients Amundson, Sally A.; Grace, Marcy B.; McLeland, Christopher B. Cancer Research, Vol. 64, Issue 18 https://doi.org/10.1158/0008-5472.CAN-04-1883	journal	September 2004
Lymphoblastoid cell lines differing in p53 status show clear differences in basal gene expression with minor changes after irradiation Zschenker, Oliver; Borgmann, Kerstin; Streichert, Thomas Radiotherapy and Oncology, Vol. 80, Issue 2 https://doi.org/10.1016/j.radonc.2006.07.019	journal	August 2006
DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human Blood Budworth, Helen; Snijders, Antoine M.; Marchetti, Francesco PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0048619	journal	November 2012
Current status of biodosimetry based on standard cytogenetic methods de Lemos Pinto, Marcela Maria Pereira; Santos, Neyliane Frassinetti Gonçalves; Amaral, Ademir Radiation and Environmental Biophysics, Vol. 49, Issue 4 https://doi.org/10.1007/s00411-010-0311-3	journal	July 2010
A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects Mayer, Claudia; Popanda, Odilia; Greve, Burkhard Cancer Letters, Vol. 302, Issue 1 https://doi.org/10.1016/j.canlet.2010.12.006	journal	March 2011
Proteomic and genomic modulations induced by γ-irradiation of human blood lymphocytes Turtoi, Andrei; Sharan, Rajeshwar N.; Srivastava, Alok International Journal of Radiation Biology, Vol. 86, Issue 10 https://doi.org/10.3109/09553002.2010.486016	journal	July 2010
Unique patterns of regulation of nitric oxide production in fibroblasts Lavnikova, Natasha; Laskin, Debra L. Journal of Leukocyte Biology, Vol. 58, Issue 4 https://doi.org/10.1002/jlb.58.4.451	journal	October 1995
Expression of the Oxidative Base Excision Repair Enzymes is not Induced in TK6 Human Lymphoblastoid Cells after Low Doses of Ionizing Radiation Inoue, M.; Shen, G-P.; Chaudhry, M. A. Radiation Research, Vol. 161, Issue 4 https://doi.org/10.1667/3163	journal	April 2004

Similar Records

DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human Blood

Journal Article · 2012 · PLoS ONE · OSTI ID:1627556

Uncertainty and relative risks of radiation exposure

Journal Article · 1987 · JAMA, J. Am. Med. Assoc.; (United States) · OSTI ID:6019540

Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

Journal Article · 2013 · Toxicology and Applied Pharmacology · OSTI ID:22285430

Human blood molecular biodosimeter panel for distinguishing radiation exposure from inflammation stress

Citation Formats

References (47)

Similar Records

Related Subjects