Cell-free metabolic pathway for glucose metabolism with a molecular purge valve

Bowie, James U.; Korman, Tyler P.; Opgenorth, Paul H.

Cell-free metabolic pathway for glucose metabolism with a molecular purge valve

Patent · 31 August 2021

OSTI ID:1840388

Bowie, James U.; Korman, Tyler P.; Opgenorth, Paul H.

Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.

Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AR0000556

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 11,104,919

Application Number:: 15/744,049

OSTI ID:: 1840388

Country of Publication:: United States

Language:: English

References (8)

Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae Su, Wan; Xiao, Wen-Hai; Wang, Ying PLOS ONE, Vol. 10, Issue 6 https://doi.org/10.1371/journal.pone.0130840	journal	June 2015
Synthetic non-oxidative glycolysis enables complete carbon conservation Bogorad, Igor W.; Lin, Tzu-Shyang; Liao, James C. Nature, Vol. 502, Issue 7473 https://doi.org/10.1038/nature12575	journal	September 2013
A synthetic biochemistry molecular purge valve module that maintains redox balance Opgenorth, Paul H.; Korman, Tyler P.; Bowie, James U. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5113	journal	June 2014
Application of Functional Genomics to Pathway Optimization for Increased Isoprenoid Production Kizer, L.; Pitera, D. J.; Pfleger, B. F. Applied and Environmental Microbiology, Vol. 74, Issue 10 https://doi.org/10.1128/AEM.02750-07	journal	March 2008
A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates : Production of Isoprene from Glycolysis Intermediates Korman, Tyler P.; Sahachartsiri, Bobby; Li, Dan Protein Science, Vol. 23, Issue 5 https://doi.org/10.1002/pro.2436	journal	March 2014
Genetic switchboard for synthetic biology applications Callura, J. M.; Cantor, C. R.; Collins, J. J. Proceedings of the National Academy of Sciences, Vol. 109, Issue 15 https://doi.org/10.1073/pnas.1203808109	journal	March 2012
Escherichia coli Malic Enzymes: Two Isoforms with Substantial Differences in Kinetic Properties, Metabolic Regulation, and Structure Bologna, F. P.; Andreo, C. S.; Drincovich, M. F. Journal of Bacteriology, Vol. 189, Issue 16 https://doi.org/10.1128/JB.00428-07	journal	June 2007
A synthetic biochemistry module for production of bio-based chemicals from glucose Opgenorth, Paul H.; Korman, Tyler P.; Bowie, James U. Nature Chemical Biology, Vol. 12, Issue 6 https://doi.org/10.1038/nchembio.2062	journal	April 2016

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Cell-free metabolic pathway for glucose metabolism with a molecular purge valve

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