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Automated control of microfluidic devices based on machine learning

Patent ·
OSTI ID:1840253

A system is provided to automatically monitor and control the operation of a microfluidic device using machine learning technology. The system receives images of a channel of a microfluidic device collected by a camera during operation of the microfluidic device. Upon receiving an image, the system applies a classifier to the image to classify the operation of the microfluidic device as normal, in which no adjustment to the operation is needed, or as abnormal, in which an adjustment to the operation is needed. When an image is classified as normal, the system may make no adjustment to the microfluidic device. If, however, an image is classified as abnormal, the system may output an indication that the operation is abnormal, output an indication of a needed adjustment, or control the microfluidic device to make the needed adjustment.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Number(s):
11,061,042
Application Number:
16/376,380
OSTI ID:
1840253
Country of Publication:
United States
Language:
English

References (6)

Microfluidics: Fluid physics at the nanoliter scale journal October 2005
Large-Scale Video Classification with Convolutional Neural Networks conference June 2014
Monodisperse Double Emulsions Generated from a Microcapillary Device journal April 2005
Microfluidic sensing: state of the art fabrication and detection techniques journal January 2011
Double emulsion production in glass capillary microfluidic device: Parametric investigation of droplet generation behaviour journal July 2015
Encapsulated liquid sorbents for carbon dioxide capture journal February 2015

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