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Office of Scientific and Technical Information
 

MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid

Journal Article · · Structure
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Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1839750
Journal Information:
Structure, Vol. 27, Issue (8)
Country of Publication:
United States
Language:
ENGLISH

References (57)

PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction journal September 2017
A Structural Model for the Generation of Continuous Curvature on the Surface of a Retroviral Capsid journal March 2012
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles journal August 2012
The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein. journal January 1997
Host and Viral Determinants of Mx2 Antiretroviral Activity journal April 2014
Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function journal November 2009
Microbatch crystallization under oil — a new technique allowing many small-volume crystallization trials journal August 1992
The CCP4 suite programs for protein crystallography journal September 1994
MxB is an interferon-induced restriction factor of human herpesviruses journal May 2018
Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique journal September 2017
Coot model-building tools for molecular graphics journal November 2004
Crystal Structure of the Full-Length Feline Immunodeficiency Virus Capsid Protein Shows an N-Terminal β-Hairpin in the Absence of N-Terminal Proline journal November 2017
Specific incorporation of cyclophilin A into HIV-1 virions journal November 1994
Structural Insight into HIV-1 Restriction by MxB journal November 2014
MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 journal August 2014
Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function journal October 2011
A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2 journal February 2015
Transfer of the Amino-Terminal Nuclear Envelope Targeting Domain of Human MX2 Converts MX1 into an HIV-1 Resistance Factor journal June 2014
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection journal September 2013
X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability journal June 2015
Mx GTPases: dynamin-like antiviral machines of innate immunity journal March 2015
In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects journal January 2014
VMD: Visual molecular dynamics journal February 1996
Large-Scale Functional Purification of Recombinant HIV-1 Capsid journal March 2013
MXB inhibits murine cytomegalovirus journal September 2018
Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26 journal February 1999
Temperature dependence of TIP3P, SPC, and TIP4P water from NPT Monte Carlo simulations: Seeking temperatures of maximum density journal July 1998
Integration, scaling, space-group assignment and post-refinement journal January 2010
XDS journal January 2010
MX2 is an interferon-induced inhibitor of HIV-1 infection journal October 2013
Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB journal June 2004
Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid journal November 2014
Rosetta3: An Object-Oriented Software Suite for the Simulation and Design of Macromolecules book January 2011
Flexible Use of Nuclear Import Pathways by HIV-1 journal March 2010
Accurate and efficient integration for molecular dynamics simulations at constant temperature and pressure journal October 2013
The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection journal October 2013
The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB journal January 2015
Host and viral determinants for MxB restriction of HIV-1 infection journal October 2014
Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity journal October 2013
Phaser crystallographic software journal July 2007
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography journal June 2015
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
Scalable molecular dynamics with NAMD journal January 2005
X-Ray Structures of the Hexameric Building Block of the HIV Capsid journal June 2009
Human MxB Protein Is a Pan-herpesvirus Restriction Factor journal June 2018
Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal journal June 2015
Gaussian split Ewald: A fast Ewald mesh method for molecular simulation journal February 2005
Anton 2: Raising the Bar for Performance and Programmability in a Special-Purpose Molecular Dynamics Supercomputer
  • Shaw, David E.; Grossman, J. P.; Bank, Joseph A.
  • SC14: International Conference for High Performance Computing, Networking, Storage and Analysis https://doi.org/10.1109/SC.2014.9
conference November 2014
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5  restriction factor journal March 2006
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein journal May 2003
Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations journal June 2016
Overview of the CCP 4 suite and current developments journal March 2011
Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2 journal January 2015
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor journal October 2003
The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid journal March 2013

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