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Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containi

Journal Article · · Nucleic Acids Res.
DOI:https://doi.org/10.1093/nar/gkab460· OSTI ID:1836734

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1836734
Journal Information:
Nucleic Acids Res., Vol. 49, Issue (20)
Country of Publication:
United States
Language:
ENGLISH

References (96)

A Genetic Map of the Response to DNA Damage in Human Cells journal July 2020
RNA m6A methylation regulates the ultraviolet-induced DNA damage response journal March 2017
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation journal August 2020
RNA modifications: what have we learned and where are we headed? journal May 2016
RNA modifications modulate gene expression during development journal September 2018
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription journal January 2020
Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells journal October 1977
DNA double-strand break repair-pathway choice in somatic mammalian cells journal July 2019
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control journal November 2017
N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis journal October 2019
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2 journal August 2020
METTL3 regulates heterochromatin in mouse embryonic stem cells journal January 2021
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity journal March 2021
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally journal March 2019
An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine journal February 2021
m6A RNA methylation regulates the fate of endogenous retroviruses journal January 2021
m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation journal January 2015
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation journal October 1998
KAP1 controls endogenous retroviruses in embryonic stem cells journal January 2010
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET journal February 2010
Epigenetic inheritance at the agouti locus in the mouse journal November 1999
Immunochemical evidence for the presence of 5mC, 6mA and 7mG in human, Drosophila and mealybug DNA journal July 1983
DNA methylation on N6-adenine in mammalian embryonic stem cells journal March 2016
N-methyladenine DNA Modification in Glioblastoma journal November 2018
N6-methyladenine in DNA antagonizes SATB1 in early development journal July 2020
Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome journal March 2017
Quantitative LC-MS Provides No Evidence for m 6 dA or m 4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues journal March 2017
No evidence for DNA N 6 -methyladenine in mammals journal March 2020
The origin of genomic N6-methyl-deoxyadenosine in mammalian cells journal March 2020
Peaking at the right time journal August 2020
Altered DNA base could play key role in pregnancy journal July 2020
The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond journal July 2015
The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity journal October 2020
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation journal January 2018
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation journal October 2020
Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro journal December 2019
Nucleotide Excision Repair in Eukaryotes journal October 2013
The Carboxy-Terminal Domain of ROS1 Is Essential for 5-Methylcytosine DNA Glycosylase Activity journal November 2014
Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA journal July 2020
Methyltransferase-Glo: a universal, bioluminescent and homogenous assay for monitoring all classes of methyltransferases journal March 2016
Multiparametric scaling of diffraction intensities journal April 2003
Phaser crystallographic software journal July 2007
Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution journal March 2012
Coot model-building tools for molecular graphics journal November 2004
A New Generation of Crystallographic Validation Tools for the Protein Data Bank journal October 2011
Formation of Cyclopyrimidines Via the Direct Effects of Gamma Radiation of Pyrimidine Nucleosides journal January 1988
Thymine Dimer-Induced Structural Changes to the DNA Duplex Examined with Reactive Probes journal November 2008
Base Pair Opening in a Deoxynucleotide Duplex Containing a cis-syn Thymine Cyclobutane Dimer Lesion journal December 2013
Influence of a cis,syn-cyclobutane pyrimidine dimer damage on DNA conformation studied by molecular dynamics simulations: cis,syn-Cyclobutane Pyrimidine Dimer Damage on DNA Conformation journal January 2015
Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution journal July 2016
ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma journal July 2018
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers journal December 2018
International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data journal January 2011
Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet light journal September 2019
TERT Promoter Mutations in Familial and Sporadic Melanoma journal January 2013
Highly Recurrent TERT Promoter Mutations in Human Melanoma journal January 2013
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal journal March 2013
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma journal October 2013
Frequency of TERT promoter mutations in primary tumors of the liver journal September 2014
TERT promoter mutations and monoallelic activation of TERT in cancer journal December 2015
Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology—a narrative review journal October 2020
New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma journal August 2020
TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma journal July 2018
TERT promoter mutations and telomeres during tumorigenesis journal February 2020
Chemical excitation of electrons: A dark path to melanoma journal August 2016
Chemiexcitation and Its Implications for Disease journal June 2018
Role of Melanin Chemiexcitation in Melanoma Progression and Drug Resistance journal August 2020
The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site journal October 2019
New insights into abasic site repair and tolerance journal June 2020
Sequencing abasic sites in DNA at single-nucleotide resolution journal June 2019
Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination journal February 2013
Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells journal March 2010
Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity journal February 2010
Mechanism of somatic hypermutation at the WA motif by human DNA polymerase   journal April 2013
How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis journal March 2015
The nucleotide pool is a significant target for oxidative stress journal August 2006
Incorporation of the Guanosine Triphosphate Analogs 8-Oxo-dGTP and 8-NH2-dGTP by Reverse Transcriptases and Mammalian DNA Polymerases journal February 1997
Incorporation and Replication of 8-Oxo-deoxyguanosine by the Human Mitochondrial DNA Polymerase journal November 2006
Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity journal February 2008
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide journal November 2014
The m 6 A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide journal January 2017
The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool journal June 2002
MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae journal September 1999
An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase   journal October 2009
Interactions among the Escherichia coli mutT, mutM, and mutY damage prevention pathways journal February 2003
A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA journal January 2005
A Role for N6-Methyladenine in DNA Damage Repair journal March 2021
Reading m6A in the Transcriptome: m6A-Binding Proteins journal February 2018
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain journal September 2014
Identification of YTH Domain-Containing Proteins as the Readers for N 1-Methyladenosine in RNA journal April 2018
Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA journal December 2015
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily journal April 2011
Holliday junction-resolving enzymes-structures and mechanisms journal January 2017
Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex journal May 2019
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA journal February 2020
EFFECTS OF HIGH LEVELS OF DNA ADENINE METHYLATION ON METHYL-DIRECTED MISMATCH REPAIR IN ESCHERICHIA COLI journal August 1983