The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
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journal
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October 2008 |
Integrin αIIbβ3: From Discovery to Efficacious Therapeutic Target
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journal
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April 2013 |
Osteoclasts, integrins, and osteoporosis
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journal
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October 2000 |
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance
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journal
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April 2015 |
The role of β3-integrins in tumor angiogenesis: context is everything
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journal
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October 2011 |
Osteoporosis and Integrins
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journal
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April 2005 |
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.
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journal
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May 1997 |
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
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journal
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January 2014 |
Monoclonal antibodies to αVβ3 (7E3 and LM609) inhibit sickle red blood cell–endothelium interactions induced by platelet-activating factor
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journal
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January 2000 |
Small-molecule cyclic αVβ3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion
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journal
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August 2007 |
Tumor Angiogenesis: Putting a Value on Plastic GEMMs
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journal
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January 2014 |
Integrin αvβ3 Signaling in Tumor-Induced Bone Disease
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journal
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July 2017 |
Herpes Simplex Virus Type 2 Glycoprotein H Interacts with Integrin v 3 To Facilitate Viral Entry and Calcium Signaling in Human Genital Tract Epithelial Cells
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journal
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June 2014 |
Andes Virus Recognition of Human and Syrian Hamster β 3 Integrins Is Determined by an L33P Substitution in the PSI Domain
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journal
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January 2010 |
3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure
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journal
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June 1998 |
A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease
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journal
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June 2017 |
Blocking α V β 3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats
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journal
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January 2014 |
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
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journal
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October 2013 |
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
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journal
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November 2013 |
Engagement of αvβ3 Integrin Regulates Proliferation and Apoptosis of Hepatic Stellate Cells
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journal
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June 2004 |
Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro
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journal
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May 2007 |
Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ3 for staging liver fibrosis in rat model
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journal
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March 2016 |
Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging
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journal
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December 2015 |
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
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journal
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July 2013 |
The role of vitronectin receptor (αvβ3) and tissue factor in the pathogenesis of transplant coronary vasculopathy
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journal
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March 2002 |
Myocardial Ischemic Injury After Heart Transplantation Is Associated With Upregulation of Vitronectin Receptor (α v β 3 ), Activation of the Matrix Metalloproteinase Induction System, and Subsequent Development of Coronary Vasculopathy
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journal
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April 2002 |
β 3 Integrin Subunit Mediates the Bone-Resorbing Function Exerted by Cultured Myeloma Plasma Cells
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journal
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August 2009 |
Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis
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journal
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February 2016 |
Increased Activation of Latent TGF-β1 by αVβ3 in Human Crohnʼs Disease and Fibrosis in TNBS Colitis Can Be Prevented by Cilengitide
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journal
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January 2013 |
Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells
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journal
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December 2015 |
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
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journal
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January 2015 |
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice
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journal
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April 2019 |
Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors
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journal
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September 2017 |
Soluble Urokinase Receptor and Chronic Kidney Disease
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journal
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November 2015 |
SuPAR, an emerging biomarker in kidney and inflammatory diseases
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journal
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September 2018 |
Alpha-v Integrins as Therapeutic Targets in Oncology
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journal
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January 2007 |
End of the road: confounding results of the CORE trial terminate the arduous journey of cilengitide for glioblastoma
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journal
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February 2015 |
Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome
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journal
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February 2016 |
Effect of L-000845704, an αVβ3 Integrin Antagonist, on Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporotic Women
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journal
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April 2005 |
Evaluation of the safety, pharmacokinetics and treatment effects of an α ν β 3 integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases
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journal
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March 2010 |
Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.
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journal
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September 1987 |
Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.
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journal
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April 1990 |
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
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journal
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September 1991 |
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
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journal
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September 2004 |
Integrin Priming Dynamics: Mechanisms of Integrin Antagonist-Promoted αIIbβ3:PAC-1 Molecular Recognition
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journal
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August 2009 |
β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α IIb β 3 Headpiece
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journal
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December 2015 |
Structure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
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journal
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March 2012 |
α IIb β 3 priming and clustering by orally active and intravenous integrin antagonists
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journal
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March 2007 |
Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)
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journal
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May 1991 |
Application of high-throughput screening to identify a novel αIIb-specific small- molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen
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journal
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February 2008 |
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening
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journal
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December 2010 |
Oral Glycoprotein IIb/IIIa Inhibitors: Why Don??t They Work?
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journal
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January 2001 |
Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes
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journal
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November 2000 |
Oral GPIIb / IIIa Antagonists: What Went Wrong?
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journal
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May 2004 |
Differential Expression of a Ligand Induced Binding Site (LIBS) by GPIIb-IIIa Ligand Recognition Peptides and Parenteral Antagonists
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journal
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January 2000 |
Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin
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journal
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June 2012 |
Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3 in Complex with an Arg-Gly-Asp Ligand
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journal
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March 2002 |
Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin Subunit
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journal
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May 1995 |
A Naturally Occurring Point Mutation in the β3 Integrin MIDAS-like Domain Affects Differently αvβ3 and αIIbβ3 Receptor Function
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journal
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January 2001 |
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
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journal
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March 2009 |
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
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journal
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September 2002 |
Superactivation of integrin (α)v(β)3 by low antagonist concentrations
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journal
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April 2001 |
Soluble alpha v beta 3-integrin ligands raise [Ca2+]i in rat osteoclasts and mouse-derived osteoclast-like cells
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journal
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February 1994 |
Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
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journal
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July 2009 |
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
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journal
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March 2014 |
Structural Basis for the Interaction of isoDGR with the RGD-binding Site of αvβ3 Integrin
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journal
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July 2008 |
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α v β 3 without Promoting Integrin Allosteric Activation
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journal
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June 2018 |
Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist
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journal
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August 1995 |
Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis
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journal
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April 2015 |
Nonpeptide α v β 3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent α v β 3 Antagonists for the Prevention and Treatment of Osteoporosis
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journal
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August 2004 |
Structure and mechanics of integrin-based cell adhesion
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journal
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October 2007 |
Use of the mouse aortic ring assay to study angiogenesis
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journal
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December 2011 |
Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice
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journal
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January 2014 |
αvβ3 Integrin and tumour blood vessels—learning from the past to shape the future
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journal
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October 2016 |
Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3
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journal
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September 2001 |
Mechanisms and Consequences of Affinity Modulation of Integrin αVβ3 Detected with a Novel Patch-engineered Monovalent Ligand
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journal
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July 1999 |
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
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journal
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July 2011 |
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
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journal
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April 2018 |
Platelet vitronectin receptor expression differentiates Iraqi-Jewish from Arab patients with Glanzmann thrombasthenia in Israel
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journal
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January 1991 |
Should studies on Glanzmann thrombasthenia not be telling us more about cardiovascular disease and other major illnesses?
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journal
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September 2017 |
An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model
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journal
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September 2017 |
The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel.
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journal
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April 1991 |
Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
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journal
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February 2000 |
Dissection of platelet and myeloid cell defects by conditional targeting of the β3‐integrin subunit
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journal
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November 2009 |
Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis
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journal
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December 2014 |
Critical Role of β3 Integrin in Experimental Postmenopausal Osteoporosis
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journal
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July 2005 |
Upregulation of osteoclast α2β1 integrin compensates for lack of αvβ3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia: Osteoclast Function in Glanzmann Thrombasthenia
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journal
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September 2003 |
PLATELET GLYCOPROTEIN IIb-IIIa-LIKE PROTEINS MEDIATE ENDOTHELIAL CELL ATTACHMENT TO ADHESIVE MATRIX PROTEINS AND ARE UP-REGULATED BY PHORBOL ESTERS
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conference
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August 2018 |
Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
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journal
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April 1993 |
Identification and Characterization of the New Osteoclast Progenitor with Macrophage Phenotypes Being Able to Differentiate into Mature Osteoclasts
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journal
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August 2000 |
Fiji: an open-source platform for biological-image analysis
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journal
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June 2012 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Phaser crystallographic software
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journal
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July 2007 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
A systematic survey of conformational states in β1 and β4 integrins using negative-stain electron microscopy
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journal
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April 2018 |
Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line
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journal
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October 2002 |
Negative staining and image classification — powerful tools in modern electron microscopy
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journal
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January 2004 |
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
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journal
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December 2012 |
EMAN2: An extensible image processing suite for electron microscopy
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journal
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January 2007 |
SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields
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journal
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January 1996 |