Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule

Fritschi, Christopher J.; Liang, Shuaiyi; Mohammadi, Mohammadjavad; Anang, Saumya; Moraca, Francesca; Chen, Junhua; Madani, Navid; Sodroski, Joseph G.; Abrams, Cameron F.; Hendrickson, Wayne A.; Smith III, Amos B.

doi:10.1021/acsmedchemlett.1c00437

Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule

Journal Article · 01 October 2021 · ACS Med. Chem. Lett.

DOI:https://doi.org/10.1021/acsmedchemlett.1c00437· OSTI ID:1836704

Fritschi, Christopher J.; Liang, Shuaiyi; Mohammadi, Mohammadjavad; Anang, Saumya; Moraca, Francesca; Chen, Junhua; Madani, Navid; Sodroski, Joseph G.; Abrams, Cameron F.; Hendrickson, Wayne A.; Smith III, Amos B.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Science Foundation (NSF)

OSTI ID:: 1836704

Journal Information:: ACS Med. Chem. Lett., Vol. 12, Issue (11)

Country of Publication:: United States

Language:: ENGLISH

References (22)

Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence No authors listed Current Opinion in Infectious Diseases https://doi.org/10.1097/QCO.0b013e32834ef5ef		January 2012
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women No authors listed Science https://doi.org/10.1126/science.1193748		July 2010
The design of drugs for HIV and HCV No authors listed Nature Reviews Drug Discovery https://doi.org/10.1038/nrd2424		December 2007
Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist No authors listed Accounts of Chemical Research https://doi.org/10.1021/ar4002735		February 2014
Recent Progress in the Development of HIV-1 Entry Inhibitors: From Small Molecules to Potent Anti-HIV Agents No authors listed Current Topics in Medicinal Chemistry https://doi.org/10.2174/1568026619666190712204050		October 2019
Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State No authors listed PLoS Pathogens https://doi.org/10.1371/journal.ppat.1000360		April 2009
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity No authors listed Cell Host & Microbe https://doi.org/10.1016/j.chom.2019.03.002		April 2019
Impact of HIV-1 Envelope Conformation on ADCC Responses No authors listed Trends in Microbiology https://doi.org/10.1016/j.tim.2017.10.007		April 2018
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions No authors listed Science https://doi.org/10.1126/science.1254426		October 2014
The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals No authors listed Journal of Virology https://doi.org/10.1128/JVI.02868-14		October 2014
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins No authors listed EBioMedicine https://doi.org/10.1016/j.ebiom.2016.09.004		October 2016
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir No authors listed Cell Host & Microbe https://doi.org/10.1016/j.chom.2021.04.014		June 2021
Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4 No authors listed Virology https://doi.org/10.1016/j.virol.2005.06.008		September 2005
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition No authors listed ACS Medicinal Chemistry Letters https://doi.org/10.1021/acsmedchemlett.5b00471		January 2016
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation No authors listed Nature Communications https://doi.org/10.1038/s41467-021-21816-x		March 2021
Optimization of CD4/gp120 Inhibitors by Thermodynamic-Guided Alanine-Scanning Mutagenesis: Optimization of Protein/Protein Inhibitors No authors listed Chemical Biology & Drug Design https://doi.org/10.1111/cbdd.12075		December 2012
Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-trifluoroacetate Salt No authors listed Organic Process Research & Development https://doi.org/10.1021/acs.oprd.9b00353		October 2019
γ-Sultam-cored N,N-ligands in the ruthenium( ii )-catalyzed asymmetric transfer hydrogenation of aryl ketones No authors listed Organic & Biomolecular Chemistry https://doi.org/10.1039/C5OB02352A		January 2016
First Synthesis of 1-Phenyl-3-pyrrol-1-ylindan-2-carboxylic Acid, a New Scaffold of Potential Non-peptide Endothelin Receptor Antagonists No authors listed Synlett https://doi.org/10.1055/s-1999-2793		August 1999
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site No authors listed mBio https://doi.org/10.1128/mBio.00280-20		June 2020
Structure of a V3-Containing HIV-1 gp120 Core No authors listed Science https://doi.org/10.1126/science.1118398		November 2005
Catalytic Asymmetric Dihydroxylation No authors listed Chemical Reviews https://doi.org/10.1021/cr00032a009		December 1994

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