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Title: Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad

Journal Article · · Angew. Chem. Int. Ed.
; ; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Science Foundation (NSF)
OSTI ID:
1836693
Journal Information:
Angew. Chem. Int. Ed., Vol. 58, Issue (45)
Country of Publication:
United States
Language:
ENGLISH

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The low barrier hydrogen bond (LBHB) proposal revisited: The case of the Asp ··· His pair in serine proteases journal April 2004
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Combined High-Resolution Neutron and X-ray Analysis of Inhibited Elastase Confirms the Active-Site Oxyanion Hole but Rules against a Low-Barrier Hydrogen Bond journal August 2009
Subangstrom Crystallography Reveals that Short Ionic Hydrogen Bonds, and Not a His-Asp Low-Barrier Hydrogen Bond, Stabilize the Transition State in Serine Protease Catalysis journal July 2006
X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Short Ionic Hydrogen Bond SIHB with Catalytic Aspartate journal May 2010
A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad journal April 2018
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Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2-Aminopyridine Become Protonated Upon Binding to Trypsin journal March 2017
Ladungen verschieben Protonierungen: Neutronenbeugung zeigt, dass Anilin und 2-Aminopyridin protoniert an Trypsin binden journal March 2017
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Electrostatic Interactions Guide the Active Site Face of a Structure-Specific Ribonuclease to Its RNA Substrate † journal August 2008
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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation journal February 2013
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Aminoglycoside 2′-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates journal August 2002
Protein Dynamics Are Influenced by the Order of Ligand Binding to an Antibiotic Resistance Enzyme journal December 2013
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