Regulation of Contraction in Striated Muscle
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January 2000 |
Calcium, thin Filaments, and the Integrative Biology of Cardiac Contractility
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March 2005 |
Atomic model of a myosin filament in the relaxed state
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August 2005 |
Three-dimensional structure of vertebrate cardiac muscle myosin filaments
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February 2008 |
Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2
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April 2001 |
Visualization of Head–Head Interactions in the Inhibited State of Smooth Muscle Myosin
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December 1999 |
Structures of Smooth Muscle Myosin and Heavy Meromyosin in the Folded, Shutdown State
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October 2007 |
Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution
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April 2008 |
Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 Å resolution
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September 2016 |
X-Ray Solution Scattering of Squid Heavy Meromyosin: Strengthening the Evidence for an Ancient Compact off State
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December 2013 |
Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function
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September 2017 |
Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease
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September 2017 |
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
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July 2017 |
Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases
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March 2014 |
Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
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February 2019 |
The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy
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January 2015 |
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
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October 2018 |
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
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August 2018 |
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
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April 2020 |
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin
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January 2019 |
MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
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June 2017 |
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
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December 2016 |
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
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June 2019 |
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
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February 2016 |
Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca 2+ flux caused by thin filament hypertrophic cardiomyopathy mutations
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March 2020 |
Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin
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July 2018 |
Kinetic Mechanism of Blebbistatin Inhibition of Nonmuscle Myosin IIB †
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November 2004 |
Mechanism of Blebbistatin Inhibition of Myosin II
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June 2004 |
Specificity of blebbistatin, an inhibitor of myosin II
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July 2004 |
Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke
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March 2010 |
Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State
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October 2008 |
Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin
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May 2009 |
Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells
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August 2008 |
Effects of myosin inhibitors on the X-ray diffraction patterns of relaxed and calcium-activated rabbit skeletal muscle fibers
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January 2018 |
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle
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September 2018 |
Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament: Myosin filament regulation in heart muscle
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November 2017 |
The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle
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October 2014 |
Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels
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January 2017 |
A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle
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August 2017 |
Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers
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December 2009 |
Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time
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September 2020 |
Small angle X-ray scattering studies on myosin
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January 1991 |
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
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May 2017 |
ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions
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June 2017 |
Global Rigid Body Modeling of Macromolecular Complexes against Small-Angle Scattering Data
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August 2005 |
The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches
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June 2020 |
228Long-term safety and effectiveness of mavacamten in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients (pts): update from PIONEER open-label extension (PIONEER-OLE) study
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October 2019 |
Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy
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June 2020 |
Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
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September 2020 |
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial
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April 2019 |
Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility
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September 2018 |
A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy
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December 2016 |
The structural basis of blebbistatin inhibition and specificity for myosin II
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March 2005 |
To lie or not to lie: Super-relaxing with myosins
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February 2021 |
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms
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January 2021 |
Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle
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September 2011 |
Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis
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March 2016 |
The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms
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May 2020 |
The Regulation of Rabbit Skeletal Muscle Contraction
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August 1971 |
The purification of cardiac myofibrils with Triton X-100
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August 1971 |
Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle
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September 1963 |
Assembly Processes in Vertebrate Skeletal Thick Filament Formation
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June 1988 |
Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential
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September 2018 |
para -Nitroblebbistatin, the Non-Cytotoxic and Photostable Myosin II Inhibitor
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June 2014 |
BioXTAS RAW : improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis
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September 2017 |
2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update
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August 2017 |