Structure?Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis

Giurgiu, Constantin; Fang, Ziyuan; Aitken, Harry R.M.; Kim, Seohyun Chris; Pazienza, Lydia; Mittal, Shriyaa; Szostak, Jack W.

doi:10.1002/anie.202109714

Structure?Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis

Journal Article · 01 October 2021 · Angew. Chem. Int. Ed.

DOI:https://doi.org/10.1002/anie.202109714· OSTI ID:1832588

Giurgiu, Constantin; Fang, Ziyuan; Aitken, Harry R.M.; Kim, Seohyun Chris; Pazienza, Lydia; Mittal, Shriyaa; Szostak, Jack W.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Science Foundation (NSF); OTHER

OSTI ID:: 1832588

Journal Information:: Angew. Chem. Int. Ed., Vol. 60, Issue (42)

Country of Publication:: United States

Language:: ENGLISH

References (28)

Origin of life: The RNA world No authors listed Nature https://doi.org/10.1038/319618a0		February 1986
The eightfold path to non-enzymatic RNA replication No authors listed Journal of Systems Chemistry https://doi.org/10.1186/1759-2208-3-2		February 2012
Enzyme-free genetic copying of DNA and RNA sequences No authors listed Beilstein Journal of Organic Chemistry https://doi.org/10.3762/bjoc.14.47		January 2018
A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension No authors listed Journal of the American Chemical Society https://doi.org/10.1021/jacs.6b07977		September 2016
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides No authors listed Journal of the American Chemical Society https://doi.org/10.1021/jacs.6b13148		January 2017
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying No authors listed Angewandte Chemie International Edition https://doi.org/10.1002/anie.201805785		July 2018
A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying No authors listed Angewandte Chemie https://doi.org/10.1002/ange.201805785		July 2018
Nonenzymic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja00027a040		January 1992
Nonenzymatic Synthesis of RNA and DNA Oligomers on Hexitol Nucleic Acid Templates: The Importance of the A Structure No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja983958r		March 1999
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.1704006114		July 2017
A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5′-phosphoro-2-aminoimidazolide No authors listed Biochemistry https://doi.org/10.1021/acs.biochem.7b00792		October 2017
The Free Energy Landscape of Pseudorotation in 3′–5′ and 2′–5′ Linked Nucleic Acids No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja412079b		February 2014
A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides No authors listed Journal of the American Chemical Society https://doi.org/10.1021/jacs.9b11239		January 2020
The Mechanism of RNA Strand Scission: An Experimental Measure of the Brønsted Coefficient,βnuc No authors listed Angewandte Chemie International Edition https://doi.org/10.1002/anie.200605124		May 2007
The Mechanism of RNA Strand Scission: An Experimental Measure of the Brønsted Coefficient,βnuc No authors listed Angewandte Chemie https://doi.org/10.1002/ange.200605124		May 2007
The p K _a 's of 2‘-Hydroxyl Group in Nucleosides and Nucleotides No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja0036312		March 2001
All Positive Ions Give Acid Solutions in Water No authors listed Journal of Chemical Education https://doi.org/10.1021/ed073p516		June 1996
Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide No authors listed Journal of the American Chemical Society https://doi.org/10.1021/jacs.7b11750		February 2018
The strength of the template effect attracting nucleotides to naked DNA No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/gku314		May 2014
Synthesis of N3′-P5′-linked Phosphoramidate DNA by Nonenzymatic Template-Directed Primer Extension No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja311164j		January 2013
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.0608952104		March 2007
Analyses of kinetic solvent isotope effects of a hammerhead ribozyme reaction in NH4+ and Li+ ions No authors listed Nucleic Acids Symposium Series https://doi.org/10.1093/nass/2.1.273		November 2002
How do the gauche and anomeric effects drive the pseudorotational equilibrium of the pentofuranose moiety of nucleosides? No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja00074a046		October 1993
How Does the Electronegativity of the Substituent Dictate the Strength of the Gauche Effect? No authors listed Journal of the American Chemical Society https://doi.org/10.1021/ja00088a043		May 1994
Nucleoside conformation is determined by the electronegativity of the sugar substituent No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/8.6.1421		January 1980
A group electronegativity method with Pauling units No authors listed Journal of Chemical Education https://doi.org/10.1021/ed062p101		February 1985
Chemical Etiology of Nucleic Acid Structure: The alpha -Threofuranosyl-(3'rightarrow 2') Oligonucleotide System No authors listed Science https://doi.org/10.1126/science.290.5495.1347		November 2000
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization No authors listed Nucleic Acids Research https://doi.org/10.1093/nar/gkaa1215		December 2020

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