Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

The middle lipin domain adopts a membrane-binding dimeric protein fold

Journal Article · · Nat. Commun.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1832580
Journal Information:
Nat. Commun., Vol. 12
Country of Publication:
United States
Language:
ENGLISH

References (50)

The Saccharomyces cerevisiae Lipin Homolog Is a Mg 2+ -dependent Phosphatidate Phosphatase Enzyme February 2006
Phospholipid metabolism and nuclear function: Roles of the lipin family of phosphatidic acid phosphatases March 2013
Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity September 2020
Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis December 2018
Lipin Expression Preceding Peroxisome Proliferator-activated Receptor-γ Is Critical for Adipogenesis in Vivo and in Vitro April 2004
Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin January 2001
Insulin Controls Subcellular Localization and Multisite Phosphorylation of the Phosphatidic Acid Phosphatase, Lipin 1 November 2006
A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2 August 2009
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood May 2010
Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome) July 2005
Mutations in LPIN1 Cause Recurrent Acute Myoglobinuria in Childhood October 2008
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle August 2014
Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator-Activated Receptor   Activation September 2006
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway September 2006
Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns November 2006
Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis December 2018
Dual function lipin proteins and glycerolipid metabolism June 2011
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin January 2002
Insulin-stimulated Interaction with 14-3-3 Promotes Cytoplasmic Localization of Lipin-1 in Adipocytes December 2009
Phosphorylation of Lipin 1 and Charge on the Phosphatidic Acid Head Group Control Its Phosphatidic Acid Phosphatase Activity and Membrane Association February 2013
Sumoylation Regulates Nuclear Localization of Lipin-1α in Neuronal Cells September 2009
Structural absorption by barbule microstructures of super black bird of paradise feathers January 2018
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway August 2011
A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase September 2010
A Phosphatidic Acid Binding/Nuclear Localization Motif Determines Lipin1 Function in Lipid Metabolism and Adipogenesis September 2010
The phosphatidic acid–binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3 October 2017
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments June 2019
Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange–MS (HDX–MS) October 2015
Dynamic structural biology at the protein membrane interface March 2019
A conserved tryptophan within the WRDPLVDID domain of yeast Pah1 phosphatidate phosphatase is required for its in vivo function in lipid metabolism October 2017
Dali server: conservation mapping in 3D May 2010
Lipin proteins form homo- and hetero-oligomers October 2010
Regulation of phosphatidic acid phosphohydrolase 1 by fatty acids January 2002
Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation May 2005
Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation May 2014
Lipin-1 Phosphatidic Phosphatase Activity Modulates Phosphatidate Levels to Promote Peroxisome Proliferator-activated Receptor γ (PPARγ) Gene Expression during Adipogenesis January 2012
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation December 2012
Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer August 2020
Characterization of the Human LPIN1-encoded Phosphatidate Phosphatase Isoforms May 2010
Assembly of High Molecular Weight Complexes of Lipin on a Supported Lipid Bilayer Observed by Atomic Force Microscopy July 2013
Escherichia coli and Sf9 Contaminant Databases to Increase Efficiency of Tandem Mass Spectrometry Peptide Identification in Structural Mass Spectrometry Experiments September 2020
The PRIDE database and related tools and resources in 2019: improving support for quantification data November 2018
DIALS : implementation and evaluation of a new integration package February 2018
CCP 4 i 2: the new graphical user interface to the CCP 4 program suite February 2018
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix October 2019
Coot model-building tools for molecular graphics November 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
Phaser crystallographic software July 2007
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity September 2020
A guided tour into subcellular colocalization analysis in light microscopy December 2006

Similar Records

The middle lipin domain adopts a membrane-binding dimeric protein fold
Journal Article · 2021 · Nat. Commun. · OSTI ID:1834914

The middle lipin domain adopts a membrane-binding dimeric protein fold
Journal Article · 2021 · Nat. Commun. · OSTI ID:1837309

The middle lipin domain adopts a membrane-binding dimeric protein fold
Journal Article · 2023 · Nature Communications · OSTI ID:1875641

Related Subjects