Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Journal Article · · Biochemistry-US

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1831227
Journal Information:
Biochemistry-US, Vol. 60, Issue (42)
Country of Publication:
United States
Language:
ENGLISH

References (43)

BIOCHEMISTRY: Creating Isoprenoid Diversity September 1997
CHEMISTRY: Roots of Biosynthetic Diversity April 2007
Structural Biology and Chemistry of the Terpenoid Cyclases August 2006
Structural and Chemical Biology of Terpenoid Cyclases August 2017
Biosynthesis of Plant Volatiles: Nature's Diversity and Ingenuity February 2006
Terpene synthases and the regulation, diversity and biological roles of terpene metabolism June 2006
Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants October 2009
Exploration and Mining of the Bacterial Terpenome October 2011
Traversing the fungal terpenome January 2014
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms January 2008
Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery June 2014
Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids January 2021
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi February 2007
Identification of Chimeric αβγ Diterpene Synthases Possessing both Type II Terpene Cyclase and Prenyltransferase Activities September 2017
Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities April 2018
Assembly-Line Catalysis in Bifunctional Terpene Synthases July 2021
Enzyme Mechanisms for Triterpene Cyclization: New Pieces of the Puzzle June 2005
Complexes of Sequential Metabolic Enzymes June 1987
The Molecular Basis of Substrate Channeling April 1999
Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions June 2001
Substrate channelling as an approach to cascade reactions March 2016
Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase January 2016
Structural insight on assembly-line catalysis in terpene biosynthesis June 2021
Higher-order oligomerization of a chimeric αβγ bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent April 2020
Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase from Saccharomyces cerevisiae and the Mechanism of Product Chain Length Determination March 2006
Regulation of product chain length by isoprenyl diphosphate synthases December 1996
A Role of the Amino Acid Residue Located on the Fifth Position before the First Aspartate-rich Motif of Farnesyl Diphosphate Synthase on Determination of the Final Product November 1996
Conversion from Farnesyl Diphosphate Synthase to Geranylgeranyl Diphosphate Synthase by Random Chemical Mutagenesis April 1996
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG November 2017
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures January 1992
Tools for integrated sequence-structure analysis with UCSF Chimera July 2006
NRGsuite: a PyMOL plugin to perform docking simulations in real time using FlexAID August 2015
Structure of the ent -Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase August 2016
Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis December 2003
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases May 2007
An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping November 2015
Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis December 2016
Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases March 2017
Fusion of farnesyldiphosphate synthase and epi -aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum : Fusions of FPPS and July 2002
Enzyme Fusion Removes Competition for Geranylgeranyl Diphosphate in Carotenogenesis October 2018
The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation May 2018
Enzyme clustering accelerates processing of intermediates through metabolic channeling September 2014
Prenyltransferase. Kinetic studies of the 1'-4 coupling reaction with avian liver enzyme. October 1979