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Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate pol

Journal Article · · MABS-Austin

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1831215
Journal Information:
MABS-Austin, Vol. 13, Issue (1)
Country of Publication:
United States
Language:
ENGLISH

References (38)

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control journal March 2012
Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library journal October 2008
Towards the Design of an Antibody that Recognises a Given Protein Epitope journal January 1999
Directing phage selections towards specific epitopes journal January 1996
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery journal November 2013
Antitumor activity, pharmacokinetics, tumor-homing effect, and hepatotoxicity of a species cross-reactive c-Met antibody journal December 2017
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display journal February 2010
Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics journal February 2015
Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability journal March 2017
Structure-based engineering of a monoclonal antibody for improved solubility journal June 2010
The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies journal April 2008
Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics journal April 2015
Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge journal September 2014
Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity journal February 2013
Reduced elimination of IgG antibodies by engineering the variable region journal February 2010
A strategy for risk mitigation of antibodies with fast clearance journal November 2012
High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice journal May 2015
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics journal January 2018
High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy journal December 2013
Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries journal January 2018
Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R journal March 2012
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys journal April 2010
In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus journal May 2010
Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool journal September 2013
Antibodies in haystacks: how selection strategy influences the outcome of selection from molecular diversity libraries journal July 2001
In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability journal December 2014
The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility journal January 2015
Improved methods for predicting peptide binding affinity to MHC class II molecules journal February 2018
T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation journal December 2013
Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions journal May 2009
A simple high-throughput purification method for hit identification in protein screening journal November 2008
Design and Use of a Phage Display Library journal August 1998
Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. journal May 1992
FLASH: fast length adjustment of short reads to improve genome assemblies journal September 2011
Towards error-free profiling of immune repertoires journal May 2014
AB ‐Bind: Antibody binding mutational database for computational affinity predictions journal November 2015
Predicting Changes in the Stability of Proteins and Protein Complexes: A Study of More Than 1000 Mutations journal July 2002
The FoldX web server: an online force field journal July 2005