Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Conformational flexibility determines the Nf2/merlin tumor suppressor functions

Journal Article · · Matrix Biol. Plus
; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Science Foundation (NSF); OTHER
OSTI ID:
1831205
Journal Information:
Matrix Biol. Plus, Vol. 12
Country of Publication:
United States
Language:
ENGLISH

References (73)

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2 journal June 1993
DNA Diagnosis of Neurofibromatosis 2: Altered Coding Sequence of the merlin Tumor Suppressor in an Extended Pedigree journal November 1993
Role of Merlin/NF2 inactivation in tumor biology journal April 2015
A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation journal August 2014
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44 journal April 2001
Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells journal December 1996
Tumor Suppressor Schwannomin/Merlin Is Critical for the Organization of Schwann Cell Contacts in Peripheral Nerves journal October 2008
Activation of the Tumor Suppressor Merlin Modulates Its Interaction with Lipid Rafts journal April 2004
Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2 journal April 2018
FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function journal March 2011
Contact-dependent inhibition of EGFR signaling by Nf2/Merlin journal June 2007
Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing journal February 2008
Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells journal November 2009
Merlin and ERM proteins: unappreciated roles in cancer development? journal November 2003
Membrane organization and tumorigenesis—the NF2 tumor suppressor, Merlin journal October 2005
The Tumor Suppressors Merlin and Expanded Function Cooperatively to Modulate Receptor Endocytosis and Signaling journal April 2006
The Nf2 Tumor Suppressor, Merlin, Functions in Rac-Dependent Signaling journal July 2001
p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin journal November 2001
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane journal October 2005
The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner journal March 2009
Merlin-Deficient Human Tumors Show Loss of Contact Inhibition and Activation of Wnt/β-Catenin Signaling Linked to the PDGFR/Src and Rac/PAK Pathways journal December 2011
Merlin/Neurofibromatosis Type 2 Suppresses Growth by Inhibiting the Activation of Ras and Rac journal January 2007
Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex journal May 2009
Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase journal October 2006
The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38SAPK pathway journal April 2012
The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton journal June 2007
Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants journal April 2010
A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions journal April 2011
Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15 journal September 2002
Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin journal December 2004
Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus journal February 2010
Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4 DCAF1 to Suppress Oncogenic Gene ExpressionA presentation from the 50th Annual Meeting of the American Society for Cell Biology in Philadelphia, Pennsylvania, 11 to 15 December 2010. journal August 2011
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis journal December 2005
Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2 journal September 2013
Discovering the Hippo pathway protein-protein interactome journal January 2014
The Hippo Signaling Pathway Interactome journal November 2013
Molecular insights into NF2 /Merlin tumor suppressor function journal April 2014
Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway journal June 2015
ERM proteins and merlin: integrators at the cell cortex journal August 2002
Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain journal February 2007
Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain journal May 2001
Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain journal April 2000
Merlin Differs from Moesin in Binding to F-Actin and in Its Intra- and Intermolecular Interactions journal July 1998
Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. journal September 1994
The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association journal May 2001
Merlin differentially associates with the microtubule and actin cytoskeleton journal February 1998
Hierarchy of Merlin and Ezrin N- and C-terminal Domain Interactions in Homo- and Heterotypic Associations and Their Relationship to Binding of Scaffolding Proteins EBP50 and E3KARP journal December 2000
Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes journal November 2009
Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization journal June 1998
The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State journal April 2012
Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin journal January 2000
Interdomain Interaction of Merlin Isoforms and Its Influence on Intermolecular Binding to NHE-RF journal November 1999
Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation journal August 2015
The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product journal February 2002
Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor: Unfurling and Dimerization of the Merlin FERM Domain journal November 2011
Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function journal June 2014
The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin journal May 2021
Structural Basis for Neurofibromatosis Type 2: CRYSTAL STRUCTURE OF THE MERLIN FERM DOMAIN journal December 2001
Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization journal August 2016
A deliberate approach to screening for initial crystallization conditions of biological macromolecules journal April 2003
Shape Complementarity at Protein/Protein Interfaces journal December 1993
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer journal November 2015
Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction journal October 2018
Phospholipase signalling networks in cancer journal October 2012
Critical roles of phosphoinositides and NF2 in Hippo pathway regulation journal February 2020
Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches journal June 2004
Moving in the right direction: How eukaryotic cells migrate along chemical gradients journal October 2011
High mobility of proteins in the mammalian cell nucleus journal April 2000
Phaser crystallographic software journal July 2007
Coot model-building tools for molecular graphics journal November 2004
Features and development of Coot journal March 2010
MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes journal July 2004
Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development journal January 1995

Similar Records

Related Subjects