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Title: Cross Section Measurements of Photonuclear Reaction Pathways Towards Promising Medical Radioisotopes

Abstract

Project Objectives: The goal of this project was to generate data relevant to radioisotope production while developing innovative technologies that foster and enhance novel production of radioisotopes, and, also, while providing opportunities for cultivating and training future generations of scientists. This work has provided the foundation for methodologies for determination of photonuclear cross sections over multiple energies in a single irradiation. Simultaneously, the feasibility of electron LINAC production of several in-demand radioisotopes such as 47Sc, 67Cu, 77As, and 186Re has been demonstrated. To accomplish these objectives a collaboration was formed between two complimentary facilities, the Low Energy Accelerator Facility (LEAF) at Argonne National Laboratory and the High Intensity Gamma-ray Source (HIGS) at Triangular Universities Nuclear Laboratory (TUNL). The involvement of the research group from North Carolina Central University gave students at this Historically Black University experience in forefront nuclear-physics research relevant to addressing a high-priority interdisciplinary issue. Project Description: HIGS provides a nearly monoenergetic gamma-ray beam by intra-cavity Compton backscattering of free-electron photons from electrons circulating in a storage ring. This beam can be collimated to produce a very precise energy beam. If the beam is un-collimated a calculated and precise energy spread of the beam occurs radially. The γ-fluxmore » can be evenly distributed over the radial distribution of energy and used to perform activation experiments on concentric ring targets. Thus providing multiple energy ranges in a single irradiation. Each concentric ring target can be counted separately in order to determine activation at the given energy and successively be correlated to the activation cross section. Targets were activated to determine production feasibility using electron beams at LEAF. Potential Impact: The Nuclear Science Advisory Committee recently named production of radioisotopes with electron LINACs as one of the most compelling and largest-impact opportunities for the production of high specific activity radioisotopes. Improving the photonuclear cross sectional data base with experimentally verified results will greatly enhance a researcher’s ability to rationalize electron LINAC production routes towards desired radioisotopes. This work will provide the foundation for methodologies for determination of photonuclear cross sections over multiple energies and multiple targets in a single irradiation. The techniques developed in this project will enable future studies to continue verifying theoretically predicted photonuclear cross section with experimental results. These data will also enable adaptation of models and support more precise theoretical calculation of photonuclear cross sections. This research will involve undergraduates, graduate students, and post-docs to give them a valuable research experience leading towards the next generation of scientists in the field of medical isotopes.« less

Authors:
ORCiD logo [1];  [2];  [3];  [3];  [2];  [1]
  1. North Carolina Central Univ., Durham, NC (United States)
  2. Duke Univ., Durham, NC (United States)
  3. Argonne National Lab. (ANL), Argonne, IL (United States)
Publication Date:
Research Org.:
North Carolina Central Univ., Durham, NC (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP)
Contributing Org.:
Triangle Universities Nuclear Laboratory; Argonne National Laboratory (ANL)
OSTI Identifier:
1830308
Report Number(s):
DOE-NCCU-18325
TRN: US2302054
DOE Contract Number:  
SC0018325
Resource Type:
Technical Report
Resource Relation:
Related Information: 1. Risalah NF. Cross section measurements of photonuclear reaction pathways towards promising medical radioisotopes. [Order No. 28713547]. North Carolina Central University; 2021.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 07 ISOTOPE AND RADIATION SOURCES

Citation Formats

Ahmed, Mohammad W., Howell, Calvin R., Rotsch, David, Nolen, Jr., Jerry A., Krishichayan, FNU, and Fumnilola Risalah, Noiki. Cross Section Measurements of Photonuclear Reaction Pathways Towards Promising Medical Radioisotopes. United States: N. p., 2021. Web. doi:10.2172/1830308.
Ahmed, Mohammad W., Howell, Calvin R., Rotsch, David, Nolen, Jr., Jerry A., Krishichayan, FNU, & Fumnilola Risalah, Noiki. Cross Section Measurements of Photonuclear Reaction Pathways Towards Promising Medical Radioisotopes. United States. https://doi.org/10.2172/1830308
Ahmed, Mohammad W., Howell, Calvin R., Rotsch, David, Nolen, Jr., Jerry A., Krishichayan, FNU, and Fumnilola Risalah, Noiki. 2021. "Cross Section Measurements of Photonuclear Reaction Pathways Towards Promising Medical Radioisotopes". United States. https://doi.org/10.2172/1830308. https://www.osti.gov/servlets/purl/1830308.
@article{osti_1830308,
title = {Cross Section Measurements of Photonuclear Reaction Pathways Towards Promising Medical Radioisotopes},
author = {Ahmed, Mohammad W. and Howell, Calvin R. and Rotsch, David and Nolen, Jr., Jerry A. and Krishichayan, FNU and Fumnilola Risalah, Noiki},
abstractNote = {Project Objectives: The goal of this project was to generate data relevant to radioisotope production while developing innovative technologies that foster and enhance novel production of radioisotopes, and, also, while providing opportunities for cultivating and training future generations of scientists. This work has provided the foundation for methodologies for determination of photonuclear cross sections over multiple energies in a single irradiation. Simultaneously, the feasibility of electron LINAC production of several in-demand radioisotopes such as 47Sc, 67Cu, 77As, and 186Re has been demonstrated. To accomplish these objectives a collaboration was formed between two complimentary facilities, the Low Energy Accelerator Facility (LEAF) at Argonne National Laboratory and the High Intensity Gamma-ray Source (HIGS) at Triangular Universities Nuclear Laboratory (TUNL). The involvement of the research group from North Carolina Central University gave students at this Historically Black University experience in forefront nuclear-physics research relevant to addressing a high-priority interdisciplinary issue. Project Description: HIGS provides a nearly monoenergetic gamma-ray beam by intra-cavity Compton backscattering of free-electron photons from electrons circulating in a storage ring. This beam can be collimated to produce a very precise energy beam. If the beam is un-collimated a calculated and precise energy spread of the beam occurs radially. The γ-flux can be evenly distributed over the radial distribution of energy and used to perform activation experiments on concentric ring targets. Thus providing multiple energy ranges in a single irradiation. Each concentric ring target can be counted separately in order to determine activation at the given energy and successively be correlated to the activation cross section. Targets were activated to determine production feasibility using electron beams at LEAF. Potential Impact: The Nuclear Science Advisory Committee recently named production of radioisotopes with electron LINACs as one of the most compelling and largest-impact opportunities for the production of high specific activity radioisotopes. Improving the photonuclear cross sectional data base with experimentally verified results will greatly enhance a researcher’s ability to rationalize electron LINAC production routes towards desired radioisotopes. This work will provide the foundation for methodologies for determination of photonuclear cross sections over multiple energies and multiple targets in a single irradiation. The techniques developed in this project will enable future studies to continue verifying theoretically predicted photonuclear cross section with experimental results. These data will also enable adaptation of models and support more precise theoretical calculation of photonuclear cross sections. This research will involve undergraduates, graduate students, and post-docs to give them a valuable research experience leading towards the next generation of scientists in the field of medical isotopes.},
doi = {10.2172/1830308},
url = {https://www.osti.gov/biblio/1830308}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {11}
}