Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment
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January 2019
Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer
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March 2008
Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes
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May 2012
Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness
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September 2019
Prospective identification of tumorigenic breast cancer cells
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March 2003
ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome
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November 2007
CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity
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May 2012
Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer
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January 2013
Aldehyde dehydrogenase 1 (ALDH1) expression is an independent prognostic factor in triple negative breast cancer (TNBC)
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January 2017
ALDH1 is a better clinical indicator for relapse of invasive ductal breast cancer than the CD44+/CD24− phenotype
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February 2014
Using Functional Genetics to Understand Breast Cancer Biology
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June 2010
Utilizing RNA interference to enhance cancer drug discovery
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July 2007
Targeting the cancer kinome through polypharmacology
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February 2010
Protein kinase CK2 phosphorylates and upregulates Akt/PKB
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April 2005
Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells
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August 2009
The Down syndrome-related protein kinase DYRK1A phosphorylates p27 Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation
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May 2014
Wnt/ -Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
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February 2002
The kinase TNIK is an essential activator of Wnt target genes
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October 2009
TNIK inhibition abrogates colorectal cancer stemness
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August 2016
Structural basis of CX-4945 binding to human protein kinase CK2
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November 2010
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme
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October 2001
Protein Kinase CK2 Is an Inhibitor of the Neuronal Cdk5 Kinase
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November 2004
Genome-wide survey of protein kinases required for cell cycle progression
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December 2004
Specific binding of protein kinase CK2 catalytic subunits to tubulin
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November 1999
Direct Regulation of Microtubule Dynamics by Protein Kinase CK2
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February 2004
Cancer stem cells and oncology therapeutics
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January 2007
The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
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January 2007
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
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September 2008
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
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April 2017
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
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March 2008
Cancer stem cell markers in common cancers – therapeutic implications
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October 2008
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
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April 2008
Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival
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April 2011
Aldehyde dehydrogenase 1/epidermal growth factor receptor coexpression is characteristic of a highly aggressive, poor-prognosis subgroup of high-grade serous ovarian carcinoma
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August 2013
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype
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March 2016
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis
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December 2014
Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells
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September 2009
CK2 Controls the Recruitment of Wnt Regulators to Target Genes In Vivo
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November 2006
CK2 Phosphorylation of the Armadillo Repeat Region of β-Catenin Potentiates Wnt Signaling
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June 2003
Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription
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September 2006
Inhibition of CK2α Down-Regulates Hedgehog/Gli Signaling Leading to a Reduction of a Stem-Like Side Population in Human Lung Cancer Cells
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June 2012
Inhibition of CK 2α down‐regulates Notch1 signalling in lung cancer cells
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May 2013
Self-renewal signaling pathways in breast cancer stem cells
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February 2019
Global Screening of CK2 Kinase Substrates by an Integrated Phosphoproteomics Workflow
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December 2013
Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics
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November 2017
The emerging CK2 interactome: insights into the regulation and functions of CK2
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June 2008
Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: Quantitative immunohistochemistry in tissue microarrays
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March 2011
Nuclear localization of protein kinase CK2 catalytic subunit (CK2α) is associated with poor prognostic factors in human prostate cancer
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March 2007
Protein kinase CK2 in mammary gland tumorigenesis
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May 2001
Protein Kinase CK2 in Health and Disease: CK2 and its role in Wnt and NF-κB signaling: Linking development and cancer
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April 2009
Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation
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March 1996
Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II
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October 2000
Casein Kinase 2α Regulates Multidrug Resistance-Associated Protein 1 Function via Phosphorylation of Thr249
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June 2012
CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy
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January 2012
Inhibition of casein kinase 2 prevents growth of human osteosarcoma
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December 2016
Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells
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February 2017
Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway
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September 2014
Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
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October 2013
DYRK 1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model
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September 2015
Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1
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September 2002
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
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December 2015
The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor
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August 2012
Inhibition of casein kinase 2 blocks G2 /M transition in early embryo mitosis but not in oocyte meiosis in mouse
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January 2017
CK2 functionally interacts with AKT/PKB to promote the β-catenin-dependent expression of survivin and enhance cell survival
journal
July 2011
Abstract B146: A novel TNIK inhibitor potently downregulates cancer stem cell population through attenuation of Wnt signaling
Uno, Yuko; Moriyama, Hideki; Kashimoto, Shigeki
Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; October 26-30, 2017; Philadelphia, PA, Therapeutic Agents: Small-Molecule Kinase Inhibitors
https://doi.org/10.1158/1535-7163.TARG-17-B146
conference
January 2018
Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
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July 2011
Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice
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August 2018
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia
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December 2018
Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2
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November 2010
Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas
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July 2015