Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Journal Article · · Nature
; ; ; ; ; ; ;

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; National Institutes of Health (NIH)
OSTI ID:
1828063
Journal Information:
Nature, Vol. 597
Country of Publication:
United States
Language:
ENGLISH

References (38)

Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(delta 2-isopentenyl)-adenosine tRNA modification, and spontaneous mutagenesis in Escherichia coli K-12 June 1989
Structure of Escherichia coli K-12 miaA and characterization of the mutator phenotype caused by miaA insertion mutations March 1991
Identification of the miaB Gene, Involved in Methylthiolation of Isopentenylated A37 Derivatives in the tRNA of Salmonella typhimurium andEscherichia coli December 1999
Improvement of reading frame maintenance is a common function for several tRNA modifications September 2001
Identification of an Intermediate Methyl Carrier in the Radical S -Adenosylmethionine Methylthiotransferases RimO and MiaB October 2013
First Step in Catalysis of the Radical S -Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S] 0 -Like Auxiliary Cluster January 2020
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases March 2013
MiaB, a Bifunctional Radical- S- Adenosylmethionine Enzyme Involved in the Thiolation and Methylation of tRNA, Contains Two Essential [4Fe-4S] Clusters † May 2007
The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA March 2012
Cdk5rap1-Mediated 2-Methylthio Modification of Mitochondrial tRNAs Governs Protein Translation and Contributes to Myopathy in Mice and Humans March 2015
S-adenosylmethionine tRNA modification: unexpected/unsuspected implications of former/new players January 2020
A decade of CDK5 October 2001
Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA September 2010
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis May 2010
Radical S -Adenosylmethionine Enzymes in Human Health and Disease June 2016
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli February 2008
Stereochemical Course of the Reaction Catalyzed by RimO, a Radical SAM Methylthiotransferase February 2016
Post-translational Modification of Ribosomal Proteins February 2010
Maturation of a hypermodified nucleoside in transfer RNA January 1975
Redox Behavior of the S -Adenosylmethionine (SAM)-Binding Fe–S Cluster in Methylthiotransferase RimO, toward Understanding Dual SAM Activity October 2016
A Unique RNA Fold in the RumA-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function March 2005
TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes April 2001
Snapshots of Dynamics in Synthesizing N 6 -Isopentenyladenosine at the tRNA Anticodon June 2009
Comparative genomics and evolution of proteins involved in RNA metabolism April 2002
MODOMICS: a database of RNA modification pathways. 2017 update November 2017
Protein-RNA interactions: Structural analysis and functional classes December 2006
Protein-RNA interactions: a structural analysis February 2001
MiaB Protein Is a Bifunctional Radical-S-Adenosylmethionine Enzyme Involved in Thiolation and Methylation of tRNA November 2004
Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities for S -Adenosylmethionine: Methyl Transfer by S N 2 Displacement and Radical Generation December 2011
Hydrogen-Atom Abstraction from the Adenine−Uracil Base Pair † March 2007
Dynamics of H-atom loss in adenine January 2004
RlmN and AtsB as Models for the Overproduction and Characterization of Radical SAM Proteins January 2012
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes July 2006
Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard December 2007
Features and development of Coot March 2010
Towards automated crystallographic structure refinement with phenix.refine March 2012
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG November 2017
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules May 2016

Similar Records

Related Subjects