Bipartite binding of the N terminus of Skp2 to cyclin A

Kelso, Susan; Orlicky, Stephen; Beenstock, Jonah; Ceccarelli, Derek F.; Kurinov, Igor; Gish, Gerald; Sicheri, Frank

doi:10.1016/j.str.2021.04.011

Bipartite binding of the N terminus of Skp2 to cyclin A

Journal Article · 01 September 2021 · Structure

DOI:https://doi.org/10.1016/j.str.2021.04.011· OSTI ID:1828049

Kelso, Susan; Orlicky, Stephen; Beenstock, Jonah; Ceccarelli, Derek F.; Kurinov, Igor; Gish, Gerald; Sicheri, Frank

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; FOREIGN

OSTI ID:: 1828049

Journal Information:: Structure, Vol. 29, Issue (9)

Country of Publication:: United States

Language:: ENGLISH

References (49)

Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. No authors listed Molecular and Cellular Biology https://doi.org/10.1128/MCB.16.12.6623		December 1996
The Phenix software for automated determination of macromolecular structures No authors listed Methods https://doi.org/10.1016/j.ymeth.2011.07.005		September 2011
Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo No authors listed Current Biology https://doi.org/10.1016/j.cub.2020.08.099		November 2020
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase No authors listed Nature https://doi.org/10.1038/nature02330		March 2004
A Docking Interface in the Cyclin Cln2 Promotes Multi-site Phosphorylation of Substrates and Timely Cell-Cycle Entry No authors listed Current Biology https://doi.org/10.1016/j.cub.2014.11.069		February 2015
Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1 No authors listed Cell https://doi.org/10.1016/S0092-8674(00)81065-X		March 1996
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases No authors listed Nature Cell Biology https://doi.org/10.1038/15674		October 1999
Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 No authors listed Cell Cycle https://doi.org/10.4161/cc.6.11.4278		June 2007
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 No authors listed Nature Cell Biology https://doi.org/10.1038/12013		June 1999
SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box No authors listed Cell https://doi.org/10.1016/S0092-8674(00)80098-7		July 1996
Cyclin-binding motifs are essential for the function of p21CIP1. No authors listed Molecular and Cellular Biology https://doi.org/10.1128/MCB.16.9.4673		September 1996
Features and development of Coot No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444910007493		March 2010
A new linear cyclin docking motif that mediates exclusively S‐phase CDK‐specific signaling No authors listed The EMBO Journal https://doi.org/10.15252/embj.2020105839		November 2020
A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p No authors listed Cell https://doi.org/10.1016/S0092-8674(00)80404-3		October 1997
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 No authors listed Nature Cell Biology https://doi.org/10.1038/35060126		February 2001
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction No authors listed Nature Cell Biology https://doi.org/10.1038/ncb1847		March 2009
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition No authors listed Science https://doi.org/10.1126/science.aaw2106		December 2019
Cyclin-dependent kinases and cell-cycle transitions: does one fit all? No authors listed Nature Reviews Molecular Cell Biology https://doi.org/10.1038/nrm2510		September 2008
Acetylation-Dependent Regulation of Skp2 Function No authors listed Cell https://doi.org/10.1016/j.cell.2012.05.038		July 2012
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex No authors listed Nature https://doi.org/10.1038/376313a0		July 1995
An Rb-Skp2-p27 Pathway Mediates Acute Cell Cycle Inhibition by Rb and Is Retained in a Partial-Penetrance Rb Mutant No authors listed Molecular Cell https://doi.org/10.1016/j.molcel.2004.09.029		October 2004
Skp2 Contains a Novel Cyclin A Binding Domain That Directly Protects Cyclin A from Inhibition by p27Kip1 No authors listed Journal of Biological Chemistry https://doi.org/10.1074/jbc.M603105200		August 2006
XDS No authors listed Acta Crystallographica Section D Biological Crystallography https://doi.org/10.1107/S0907444909047337		January 2010
The Ubiquitin Code No authors listed Annual Review of Biochemistry https://doi.org/10.1146/annurev-biochem-060310-170328		July 2012
p27 binds cyclin–CDK complexes through a sequential mechanism involving binding-induced protein folding No authors listed Nature Structural & Molecular Biology https://doi.org/10.1038/nsmb746		March 2004
Specificity Determinants of Recruitment Peptides Bound to Phospho-CDK2/Cyclin A ^† ^, ^‡ No authors listed Biochemistry https://doi.org/10.1021/bi0268910		December 2002
Phaser crystallographic software No authors listed Journal of Applied Crystallography https://doi.org/10.1107/S0021889807021206		July 2007
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation No authors listed Genes & Development https://doi.org/10.1101/gad.13.9.1181		May 1999
Collaboration gets the most out of software No authors listed eLife https://doi.org/10.7554/eLife.01456		September 2013
Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization No authors listed Cell Reports https://doi.org/10.1016/j.celrep.2020.107757		June 2020
UCSF Chimera?A visualization system for exploratory research and analysis No authors listed Journal of Computational Chemistry https://doi.org/10.1002/jcc.20084		January 2004
Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex No authors listed Nature https://doi.org/10.1038/382325a0		July 1996
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation No authors listed Journal of Molecular Biology https://doi.org/10.1016/j.jmb.2020.166795		March 2021
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex No authors listed Nature https://doi.org/10.1038/35042620		November 2000
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A No authors listed Proceedings of the National Academy of Sciences https://doi.org/10.1073/pnas.95.18.10453		September 1998
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega No authors listed Molecular Systems Biology https://doi.org/10.1038/msb.2011.75		January 2011
F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex No authors listed Cell https://doi.org/10.1016/S0092-8674(00)80403-1		October 1997
A CDK-Independent Function of Mammalian Cks1 No authors listed Molecular Cell https://doi.org/10.1016/S1097-2765(01)00210-6		March 2001
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells No authors listed Nature Cell Biology https://doi.org/10.1038/12027		July 1999
Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells No authors listed Cell Reports https://doi.org/10.1016/j.celrep.2016.03.049		April 2016
p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27 No authors listed Current Biology https://doi.org/10.1016/S0960-9822(99)80290-5		June 1999
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation No authors listed Nature Communications https://doi.org/10.1038/s41467-019-09446-w		April 2019
Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry No authors listed Developmental Cell https://doi.org/10.1016/j.devcel.2018.05.005		June 2018
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 No authors listed The EMBO Journal https://doi.org/10.1093/emboj/16.17.5334		September 1997
Jalview Version 2--a multiple sequence alignment editor and analysis workbench No authors listed Bioinformatics https://doi.org/10.1093/bioinformatics/btp033		January 2009
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex No authors listed Nature https://doi.org/10.1038/nature02381		March 2004
Mutational Analysis of the Cy Motif from p21 Reveals Sequence Degeneracy and Specificity for Different Cyclin-Dependent Kinases No authors listed Molecular and Cellular Biology https://doi.org/10.1128/MCB.21.15.4868-4874.2001		August 2001
Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2 No authors listed Molecular and Cellular Biology https://doi.org/10.1128/MCB.19.1.635		January 1999
pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase No authors listed Cell https://doi.org/10.1016/0092-8674(95)90271-6		September 1995

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