A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors

Kozlyuk, Natalia; Gilston, Benjamin A.; Salay, Lauren E.; Gogliotti, Rocco D.; Christov, Plamen P.; Kim, Kwangho; Ovee, Mohiuddin; Waterson, Alex G.; Chazin, Walter J.

doi:10.1002/prot.26162

A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors

Journal Article · 01 November 2021 · Proteins

DOI:https://doi.org/10.1002/prot.26162· OSTI ID:1828045

Kozlyuk, Natalia; Gilston, Benjamin A.; Salay, Lauren E.; Gogliotti, Rocco D.; Christov, Plamen P.; Kim, Kwangho; Ovee, Mohiuddin; Waterson, Alex G.; Chazin, Walter J.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; National Institutes of Health (NIH)

OSTI ID:: 1828045

Journal Information:: Proteins, Vol. 89, Issue (11)

Country of Publication:: United States

Language:: ENGLISH

References (36)

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. Neeper, M.; Schmidt, A. M.; Brett, J. Journal of Biological Chemistry, Vol. 267, Issue 21 https://doi.org/10.1016/S0021-9258(18)42138-2	journal	July 1992
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. Schmidt, A. M.; Vianna, M.; Gerlach, M. Journal of Biological Chemistry, Vol. 267, Issue 21 https://doi.org/10.1016/S0021-9258(18)42137-0	journal	July 1992
Damage-Associated Molecular Patterns in Inflammatory Diseases Roh, Jong Seong; Sohn, Dong Hyun Immune Network, Vol. 18, Issue 4 https://doi.org/10.4110/in.2018.18.e27	journal	January 2018
Role of advanced glycation end products in cellular signaling Ott, Christiane; Jacobs, Kathleen; Haucke, Elisa Redox Biology, Vol. 2 https://doi.org/10.1016/j.redox.2013.12.016	journal	January 2014
RAGE regulation and signaling in inflammation and beyond Kierdorf, Katrin; Fritz, Günter Journal of Leukocyte Biology, Vol. 94, Issue 1 https://doi.org/10.1189/jlb.1012519	journal	March 2013
RAGE Mediates a Novel Proinflammatory Axis Hofmann, Marion A.; Drury, Steven; Fu, Caifeng Cell, Vol. 97, Issue 7 https://doi.org/10.1016/S0092-8674(00)80801-6	journal	June 1999
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins Yan, S. D.; Schmidt, A. M.; Anderson, G. M. Journal of Biological Chemistry, Vol. 269, Issue 13 https://doi.org/10.1016/S0021-9258(17)36966-1	journal	April 1994
Posttranslationally Modified Proteins as Mediators of Sustained Intestinal Inflammation Andrassy, Martin; Igwe, John; Autschbach, Frank The American Journal of Pathology, Vol. 169, Issue 4 https://doi.org/10.2353/ajpath.2006.050713	journal	October 2006
Characterization and Functional Analysis of the Promoter of RAGE, the Receptor for Advanced Glycation End Products Li, Jianfeng; Schmidt, Ann Marie Journal of Biological Chemistry, Vol. 272, Issue 26 https://doi.org/10.1074/jbc.272.26.16498	journal	June 1997
Role of Hyperglycemia-Induced Advanced Glycation End Product (AGE) Accumulation in Atherosclerosis Yamagishi, Sho-ichi; Matsui, Takanori Annals of Vascular Diseases, Vol. 11, Issue 3 https://doi.org/10.3400/avd.ra.18-00070	journal	January 2018
Receptor for Advanced Glycation End Products (RAGE): A Novel Therapeutic Target for Diabetic Vascular Complication Yamagishi, Sho-ichi; Nakamura, Kazuo; Matsui, Takanori Current Pharmaceutical Design, Vol. 14, Issue 5 https://doi.org/10.2174/138161208783597416	journal	February 2008
S100 proteins in the pathogenesis and diagnosis of inflammatory bowel disease Leach, Steven T.; Day, Andrew S. Expert Review of Clinical Immunology, Vol. 2, Issue 3 https://doi.org/10.1586/1744666X.2.3.471	journal	May 2006
Assessment of the Neutrophil Dominating Protein Calprotectin in Feces: A Methodologic Study RØseth, A. G.; Fagerhol, M. K.; Aadland, E. Scandinavian Journal of Gastroenterology, Vol. 27, Issue 9 https://doi.org/10.3109/00365529209011186	journal	January 1992
All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses Oczypok, Elizabeth A.; Perkins, Timothy N.; Oury, Tim D. Paediatric Respiratory Reviews, Vol. 23 https://doi.org/10.1016/j.prrv.2017.03.012	journal	June 2017
The Extracellular Region of the Receptor for Advanced Glycation End Products Is Composed of Two Independent Structural Units ^† Dattilo, Brian M.; Fritz, Günter; Leclerc, Estelle Biochemistry, Vol. 46, Issue 23 https://doi.org/10.1021/bi7003735	journal	June 2007
Structural Basis for Ligand Recognition and Activation of RAGE Koch, Michael; Chitayat, Seth; Dattilo, Brian M. Structure, Vol. 18, Issue 10 https://doi.org/10.1016/j.str.2010.05.017	journal	October 2010
Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains Moysa, Alexander; Hammerschmid, Dietmar; Szczepanowski, Roman H. Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-56993-9	journal	December 2019
Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective Bongarzone, Salvatore; Savickas, Vilius; Luzi, Federico Journal of Medicinal Chemistry, Vol. 60, Issue 17 https://doi.org/10.1021/acs.jmedchem.7b00058	journal	May 2017
A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease Deane, Rashid; Singh, Itender; Sagare, Abhay P. Journal of Clinical Investigation, Vol. 122, Issue 4 https://doi.org/10.1172/JCI58642	journal	April 2012
RAGE-Specific Inhibitor FPS-ZM1 Attenuates AGEs-Induced Neuroinflammation and Oxidative Stress in Rat Primary Microglia Shen, Chao; Ma, Yingjuan; Zeng, Ziling Neurochemical Research, Vol. 42, Issue 10 https://doi.org/10.1007/s11064-017-2321-x	journal	June 2017
PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease Sabbagh, Marwan N.; Agro, Albert; Bell, Joanne Alzheimer Disease & Associated Disorders, Vol. 25, Issue 3 https://doi.org/10.1097/WAD.0b013e318204b550	journal	January 2011
S100P-Derived RAGE Antagonistic Peptide Reduces Tumor Growth and Metastasis Arumugam, Thiruvengadam; Ramachandran, Vijaya; Gomez, Sobeyda B. Clinical Cancer Research, Vol. 18, Issue 16 https://doi.org/10.1158/1078-0432.CCR-12-0221	journal	June 2012
Entropic Contribution to the Linking Coefficient in Fragment Based Drug Design: A Case Study Borsi, Valentina; Calderone, Vito; Fragai, Marco Journal of Medicinal Chemistry, Vol. 53, Issue 10 https://doi.org/10.1021/jm901723z	journal	May 2010
Discovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking Approach Frank, Andreas O.; Feldkamp, Michael D.; Kennedy, J. Phillip Journal of Medicinal Chemistry, Vol. 56, Issue 22 https://doi.org/10.1021/jm401333u	journal	November 2013
Fragment-based drug discovery using NMR spectroscopy Harner, Mary J.; Frank, Andreas O.; Fesik, Stephen W. Journal of Biomolecular NMR, Vol. 56, Issue 2 https://doi.org/10.1007/s10858-013-9740-z	journal	May 2013
Discovering High-Affinity Ligands for Proteins: SAR by NMR Shuker, S. B.; Hajduk, P. J.; Meadows, R. P. Science, Vol. 274, Issue 5292, p. 1531-1534 https://doi.org/10.1126/science.274.5292.1531	journal	November 1996
Stromelysin Inhibitors Designed from Weakly Bound Fragments: Effects of Linking and Cooperativity Olejniczak, E. T.; Hajduk, P. J.; Marcotte, P. A. Journal of the American Chemical Society, Vol. 119, Issue 25 https://doi.org/10.1021/ja9702780	journal	June 1997
Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products Yatime, Laure; Andersen, Gregers R. FEBS Journal, Vol. 280, Issue 24 https://doi.org/10.1111/febs.12556	journal	October 2013
Very Fast Two-Dimensional NMR Spectroscopy for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of Seconds Schanda, Paul; Brutscher, Bernhard Journal of the American Chemical Society, Vol. 127, Issue 22 https://doi.org/10.1021/ja051306e	journal	June 2005
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Fragment-based screening of programmed death ligand 1 (PD-L1) Perry, Evan; Mills, Jonathan J.; Zhao, Bin Bioorganic & Medicinal Chemistry Letters, Vol. 29, Issue 6 https://doi.org/10.1016/j.bmcl.2019.01.028	journal	March 2019
Solution Structure of the Variable-Type Domain of the Receptor for Advanced Glycation End Products: New Insight into AGE−RAGE Interaction ^, Matsumoto, Shigeyuki; Yoshida, Takuya; Murata, Hiroko Biochemistry, Vol. 47, Issue 47 https://doi.org/10.1021/bi800910v	journal	October 2008
Polder maps: improving OMIT maps by excluding bulk solvent Liebschner, Dorothee; Afonine, Pavel V.; Moriarty, Nigel W. Acta Crystallographica Section D Structural Biology, Vol. 73, Issue 2, p. 148-157 https://doi.org/10.1107/S2059798316018210	journal	February 2017

Similar Records

A fragment‐based approach to discovery of Receptor for Advanced Glycation End products inhibitors

Journal Article · 2021 · Proteins · OSTI ID:1824724

Kozlyuk, Natalia; Gilston, Benjamin A.; Salay, Lauren E.; +6 more

Journal Article · 2016 · Biochemical and Biophysical Research Communications · OSTI ID:22606161

Son, Kuk Hui; Son, Myeongjoo; Ahn, Hyosang; +4 more

Nifedipine inhibits advanced glycation end products (AGEs) and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator-activated receptor-gamma activation

Journal Article · 2010 · Biochemical and Biophysical Research Communications · OSTI ID:22202707

Matsui, Takanori; Yamagishi, Sho-ichi; Takeuchi, Masayoshi; +3 more

A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors

Citation Formats

References (36)

Similar Records

Related Subjects